The Metric Structure of Nucleic Acids and the Higher Dimension of Their Constituents

2018 ◽  
Vol 7 (2) ◽  
pp. 1-15 ◽  
Author(s):  
Gennadiy Vladimirovich Zhizhin
Keyword(s):  
Nucleic Acid ◽  
Internal Degree ◽  
Chemical Bonds ◽  
Higher Dimension ◽  
Acid Molecule ◽  
Characteristic Parameters ◽  
Experimental Characteristic ◽  
Nucleic Acid Molecule ◽  
Internal Degree Of Freedom ◽  
Angle Of Rotation

The purpose of the study is to build a metric model of the structure of a nucleic acid molecule, taking into account the higher dimension of its components, the actual lengths of chemical bonds, and the angles between them. Calculations by the constructed model showed the closeness of the known experimental characteristic parameters of the nucleic acid (helix diameter, period length) and the calculated values of these parameters. The internal degree of freedom of the nucleic acid molecule is revealed: the angle of rotation of the phosphoric acid residue relative to the chemical bond connecting it to the five-carbon sugar molecule. It is established that the value of this angle determines the shape of the nucleic acid molecule. It is claimed that the process of transmission of hereditary information and protein synthesis occurs in a space of high dimensionality in ribosomes.

scholarly journals Genomic DNA preparation enabling multiple replicate reads for accurate nanopore sequencing

2015 ◽  
Author(s):  
Dimitra Tsavachidou
Keyword(s):  
Nucleic Acid ◽  
Error Rates ◽  
Nanopore Sequencing ◽  
Acid Molecule ◽  
Single Nucleotide ◽  
Nucleic Acid Molecule ◽  
Dna Strands ◽  
Nucleotide Resolution ◽  
Single Nucleotide Resolution ◽  
Sequencing Procedure

Sequencing at single-nucleotide resolution using nanopore devices is performed with reported error rates 10.5-20.7% (Ip et al., 2015). Since errors occur randomly during sequencing, repeating the sequencing procedure for the same DNA strands several times can generate sequencing results based on consensus derived from replicate readings, thus reducing overall error rates. The method presented in this manuscript constructs copies of a nucleic acid molecule that are consecutively connected to the nucleic acid molecule. Such copies are useful because they can be sequenced by a nanopore device, enabling replicate reads, thus improving overall sequencing accuracy.

That pesky nucleic acid molecule in a protein coat

2020 ◽  
Vol 8 (4) ◽  
pp. 172-172
Author(s):  
Jane Hanley
Keyword(s):  
Nucleic Acid ◽  
Acid Molecule ◽  
Emotional Wellbeing ◽  
Nucleic Acid Molecule ◽  
Protein Coat

In March it seemed not only surreal but impossible to comprehend that the coronavirus would ever venture near our shores – and yet here it is. Jane Hanley looks at the effects of the pandemic on the emotional wellbeing of parents and professionals alike

scholarly journals An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule.

1967 ◽  
Vol 58 (1) ◽  
pp. 217-224 ◽  
Author(s):  
D. R. Mills ◽  
R. L. Peterson ◽  
S. Spiegelman
Keyword(s):  
Nucleic Acid ◽  
Acid Molecule ◽  
Nucleic Acid Molecule

scholarly journals METHYL GREEN-PYRONIN

1950 ◽  
Vol 33 (3) ◽  
pp. 265-274 ◽  
Author(s):  
N. B. Kurnick ◽  
A. E. Mirsky
Keyword(s):  
Nucleic Acid ◽  
Critical Level ◽  
Preceding Paper ◽  
Degree Of Polymerization ◽  
Methyl Green ◽  
Acid Molecule ◽  
Common Site ◽  
Green Is ◽  
Nucleic Acid Molecule ◽  
Dye Molecule

Study of the stoichiometry of the DNA-methyl green reaction by dialysis, precipitation of stain-nucleic acid mixtures, and the staining of nuclei of known DNA content, indicate that the compound consists of one dye molecule per 10 P. The significance of this result was discussed in the preceding paper (1). Histone and lanthanum (and probably other multivalent cations (3)) compete with the dye for the nucleic acid molecule, indicating a common site of attachment, presumably the phosphoric acid groups. With care in the avoidance of procedures which might depolymerize DNA, and the use of a buffer at about pH 4.1, a quantitative histochemical method for DNA by the use of methyl green is possible. Pyronin staining appears to be of qualitative significance only. Slight differences in degree of polymerization, as between the shad and mammalian DNA appear to have no effect on methyl green staining. It may be that a critical level of polymerization for DNA staining exists. This level must exceed 20 nucleotides to account for the 10 P to 1 dye molecule and the effect on the methyl green absorption spectrum; but it may be considerably greater. Beyond this critical level, whatever it may be, further polymerization probably has no influence on staining.

Characterization of nucleic acid molecule/liposome complexes and rheological effects on pluronic/alginate matrices

2007 ◽  
Vol 17 (5) ◽  
pp. 325-331 ◽  
Author(s):  
G. Grassi ◽  
R. Farra ◽  
E. Noro ◽  
D. Voinovich ◽  
R. Lapasin ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Acid Molecule ◽  
Nucleic Acid Molecule ◽  
Alginate Matrices
Sign in / Sign up

Export Citation Format

Share Document