Quantitatively Ca3SiO5 Particles Adherence Affected the Teeth Enamel Remineralization

2011 ◽  
Vol 415-417 ◽  
pp. 1215-1218
Author(s):  
Zhi Hong Dong
Keyword(s):  
Particle Size ◽  
Oral Fluid ◽  
Dental Enamel ◽  
Tricalcium Silicate ◽  
Optimal Selection ◽  
Simple Method ◽  
Particle Counter ◽  
Optical Micrograph ◽  
Adhesive Ability ◽  
Early Caries

Tricalcium silicate (Ca3SiO5) bioceramics have good bioactivity and compatibility. In simulated oral fluid they can induce teeth mineralization to repair the acid etched dental enamel. But teeth mineralization effect was relied on particles adhesive ability onto the enamel surface, so a new and simple method was established to evaluate the adherence quantitatively by optical micrograph analyzer and particle counter based on light blocking theory, and further verified Ca3SiO5 particle size affected mineralization effect in stimulated oral fluid (SOF) by nanoindentaion depth. The results indicated that particle size affected the adhesive capability and mineralization ability, in the size of 1-10μm is optimal selection as a toothpaste agent against early caries.

Formulation and Evaluation of Atenolol Nanocrystals Using 3(2) Full Factorial Design

2020 ◽  
Vol 10 (3) ◽  
pp. 306-315
Author(s):  
Rupa Mazumder ◽  
Swarnali Das Paul
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Organic Solvent ◽  
Factorial Design ◽  
Goodness Of Fit ◽  
Production Yield ◽  
Pharmacokinetic Property ◽  
Potential Yield ◽  
Simple Method ◽  
Pure Drug

Background: Atenolol is a commonly used antihypertensive drug of class III BCS category. It suffers from the problem of poor intestinal absorption or permeability thus low bioavailability. The objective of the present study was to enhance the permeability of atenolol by using a suitable technique, which is economical and devoid of using any organic solvent. Methods: The nanocrystal technology by high-pressure homogenization was chosen for this purpose, which is a less expensive and simple method. In this technique, no organic solvent was used. The study was further aimed to characterize prepared nanocrystals in the solid state by Fourier Transform Infrared Spectroscopy (FTIR), Powder X-Ray Diffraction (PXRD) patterns, particle size, zeta potential, %yield and drug permeation study through isolated goat’s intestine. An in-vivo study was carried out to determine the pharmacokinetic property in comparison to pure drug powder using rats as experimental animals. The formulation design was optimized by a 3(2) factorial design. In these designs, two factors namely surfactant amount (X1) and speed of homogenizer (X2) were evaluated on three dependent variables namely particle size (y1), zeta potential (y2) and production yield (y3). Results: PXRD study indicated the presence of high crystal content in the prepared formulation. These nanocrystal formulations were found with a narrow size range from 125 nm to 652 nm and positive zeta potential of 16-18 mV. Optimized formulations showed almost 90% production yield. Permeability study revealed 90.88% drug release for optimized formulation in comparison to the pure drug (31.22%). The FTIR study also exposed that there was no disturbance in the principal peaks of the pure drug atenolol. This confirmed the integrity of the pure drug and its compatibility with the excipients used. A significant increase in the area under the concentration-time curve Cpmax and MRT for nanocrystals was observed in comparison to the pure drug. The higher values of the determination coefficient (R2) of all three parameters indicated the goodness of fit of the 3(2) factorial model. The factorial analysis also revealed that speed of homogenizer had a bigger effect on particle size (-0.2812), zeta potential (-0.0004) and production yield (0.0192) whereas amount of surfactant had a lesser effect on production yield (-370.4401), zeta potential (-43.3651) as well as particle size (-6169.2601). Conclusion: It is concluded that the selected method of nanocrystal formation and its further optimization by factorial design was effective to increase the solubility, as well as permeability of atenolol. Further, the systematic approach of factorial design provides rational evaluation and prediction of nanocrystals formulation on the selected limited number of smart experimentation.

Effect of grain size on the vapour phase hydration of monoclinic and triclinic modifications of tricalcium silicate; role of high temperature activation

1991 ◽  
Vol 56 (10) ◽  
pp. 1993-2008
Author(s):  
S. Hanafi ◽  
G. M. S. El-Shafei ◽  
B. Abd El-Hamid
Keyword(s):  
Particle Size ◽  
Vapour Phase ◽  
Tricalcium Silicate ◽  
Active Centers ◽  
Thermally Activated ◽  
Grain Sizes ◽  
Intermediate Size ◽  
Surface Active ◽  
Temperature Activation

The hydration of tricalcium silicate (C3S) with three grain sizes of monoclinic (M) and triclinic (T) modifications and on their thermally activated samples were investigated by exposure to water vapour at 80°C for 60 days. The products were investigated by XRD, TG and N2 adsorption. The smaller the particle size the greater was the hydration for both dried and activated samples from (M). In the activated samples a hydrate with 2θ values of 38.4°, 44.6° and 48.6° could be identified. Hydration increased with particle size for the unactivated (T) samples but after activation the intermediate size exhibited enhanced hydration. Thermal treatment at 950°C of (T) samples increased the surface active centers on the expense of those in the bulk. Changes produced in surface texture upon activation and/or hydration are discussed.

A simple method to controlled synthesis of nano hydroxyapatite in different particle size

2018 ◽  
Vol 217 ◽  
pp. 177-180 ◽  
Author(s):  
Wei Liu ◽  
Gongming Qian ◽  
Lulu Liu ◽  
Bo Zhang ◽  
Xianyuan Fan
Keyword(s):  
Particle Size ◽  
Controlled Synthesis ◽  
Simple Method

Phytoplankton appearance in particle size spectra – Deriving conversion functions between microscopic and particle counter measurements

2013 ◽  
Vol 47 (5) ◽  
pp. 1928-1940 ◽  
Author(s):  
Susanne Rolinski ◽  
Patricia Pätz ◽  
Katrin Papendick ◽  
Sabine Jähnichen ◽  
Nicole Scheifhacken
Keyword(s):  
Particle Size ◽  
Size Spectra ◽  
Particle Counter

scholarly journals A Simple Method of Measuring the Particle Size of a Chloride Aerosol.

1955 ◽  
Vol 76 (4) ◽  
pp. 466-468 ◽  
Author(s):  
Isamu Sano ◽  
Yoshiyasu Fujitani ◽  
Ken Sugiyama
Keyword(s):  
Particle Size ◽  
Simple Method

PENGARUH LAJU PREKURSOR SERBUK ALUMINIUM TERHADAP BENTUK MORFOLOGI NANOPARTIKEL ALUMINA DENGAN METODE THERMAL PLASMA

ROTOR ◽  
2017 ◽  
Vol 10 (1) ◽  
pp. 17
Author(s):  
Havid Arifian Rochman ◽  
Arief Ginanjar Dirgantara ◽  
Salahudin Junus ◽  
Imam Sholahuddin ◽  
Aris Zainul Muttaqin
Keyword(s):  
Particle Size ◽  
Aluminum Powder ◽  
Thermal Plasma ◽  
High Efficiency ◽  
Average Particle Size ◽  
Alumina Nanoparticles ◽  
Rate Variation ◽  
Average Particle ◽  
Dc Plasma ◽  
Simple Method

The synthesis of nanoparticles using thermal DC plasma method is a simple method for ease of installation and high efficiency is due to the rate of precursor that can be controlled. Micro-sized aluminum powder is synthesized using thermal DC plasma undergoing a process of evaporation as it passes through high temperature plasma flame, where kemuadian oxidized aluminum particles which evaporates the particles are split and binds with oxygen to form aluminum oxide or also known as alumina (Al2O3). In this experiment, the flow rate of oxygen plasma parameters at 35 SCFH (Standard Cubic Feet per Hour) and 20 amperes flows with precursors rate variation of 1.16 g / min, 3.19 g / min, and 3.5 g / min. Precursors used is 88 micro sized aluminum powder. To determine the morphology of nanoparticles of alumina testing scanning electron microscopy (SEM), the morphology form of nanosphere. Results of the analysis showed that the rate of precursor low causing agglomeration level slightly while the higher rate of precursor agglomeration rate also increased. At the rate of precursor 1.16 g / min, nanoparikel undergo agglomeration with an average particle size of 36.55 nm, and then at a rate of 3.19 gr precursor / mnt an average particle size of 46.49 nm, and at a rate of 3.5 gr / mnt an average particle size of 46.49 nm. The powder nanoparticles were then characterized using X-ray defraksi (XRD) where all alumina nanoparticles were synthesized showed alumina phase that is formed is a phase δ-Al2O3. Keywords: Alumina nanoparticles, DC Thermal Plasma, morphology, precursor rate, nanoparticles size, SEM, XRD.

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