Evaluation of Ground Cortical Autograft as a Bone Graft Material in a New Canine Bilateral Segmental Long Bone Defect Model

Bone graft material is essential for satisfactory and sufficient bone growth which leads to a successful implant procedure. It is classified into autogenous bone, allobone, xenobone and alloplastic materials. Among them, it has been reported that heterogeneous bone graft material has a porous microstructure that increases blood vessels and bone formation, and shows faster bone formation than other types of bone graft materials. We observed new bone tissue formation and bone remodeling using Ti-oss® (Chiyewon Co., Ltd., Guri, Korea), a heterologous bone graft material. Using a Sprague–Dawley rat calvarial defect model to evaluate the bone healing effect of biomaterials, the efficacy of the newly developed xenograft Ti-oss® and Bio-Oss® (Geistilch Pharma AG, Wolhusen, Switzerland). The experimental animals were sacrificed at 8 and 12 weeks after surgery for each group and the experimental site was extracted. The average new bone area for the Ti-oss® experimental group at 8 weeks was 17.6%. The remaining graft material was 22.7% for the experimental group. The average new bone area for the Ti-oss® group was 24.3% at 12 weeks. The remaining graft material was 22.8% for the experimental group. It can be evaluated that the new bone-forming ability of Ti-oss® with octacalcium phosphate (OCP) has the bone-forming ability corresponding to the conventional products.

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Reconstruction of posttraumatic long bone defect with free vascularized bone graft: Good outcome in 48 patients with 6 years' follow-up

Acta Orthopaedica Scandinavica ◽

10.1080/000164701753542014 ◽

2001 ◽

Vol 72 (4) ◽

pp. 359-364 ◽

Cited By ~ 57

Author(s):

Yuan-Kun Tu ◽

Cheng-Yo Yen ◽

Wen-Lin Yeh ◽

I-Chun Wang ◽

Kun-Chang Wang ◽

...

Keyword(s):

Bone Graft ◽

Bone Defect ◽

Long Bone ◽

Vascularized Bone Graft ◽

Good Outcome ◽

Long Bone Defect ◽

Vascularized Bone

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Evaluation of bone healing capacity of xenogenic tooth bone graft material with polydeoxyribonucleotide in bone defect surrounding an implant

Oral Biology Research ◽

10.21851/obr.38.1.201403.9 ◽

2014 ◽

Vol 38 (1) ◽

pp. 9-16

Author(s):

이지영 ◽

윤필영 ◽

안교진 ◽

김수연 ◽

김영균 ◽

...

Keyword(s):

Bone Graft ◽

Bone Defect ◽

Bone Healing ◽

Graft Material ◽

Bone Graft Material

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Development of a Segmental Long-bone Defect Model in Sheep

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1632601 ◽

1998 ◽

Vol 11 (01) ◽

pp. 01-07 ◽

Cited By ~ 4

Author(s):

P. Frayssinet ◽

E. Asimus ◽

G. Chanoit ◽

P. Collard ◽

A. Autefage ◽

...

Keyword(s):

Bone Defect ◽

Bone Healing ◽

Healing Process ◽

Biological Properties ◽

Long Bone ◽

Defect Model ◽

Metatarsal Bones ◽

Group 2 ◽

Long Bone Defect ◽

Group 1

SummaryA 10 mm-long (Group #1) or 20 mmlong (Group #2) segmental osteoperiosteal defect was performed on the metatarsus of ten adult ewes (5+5). The goal of the study was to search for a critical size defect model leading to nonunion. The bone gap was maintained for three months with an internal fixation device involving two plates set in orthogonal planes. Radiological and histological examinations were performed on harvested metatarsal bones. Three months after surgery Group #1 animals showed obvious signs of bone healing without achieving complete union in all cases. Evidence of a healing process was not observed in Group #2 animals, and histological examination confirmed the complete failure of bone repair in the 20 mm gaps. These results are comparable to those of other authors who have concluded that a bone gap corresponding to 1.4 times the diaphyseal diameter overshoots physiological bone healing capacities. This long bone defect model showed good biological properties allowing callus settlement with minimal impairment in Group #1 and permitted weightbearing and unrestricted motion in the animals. Such a sheep model would be useful for testing hard tissue biomaterials, bone healing enhancement or further developed as an experimental nonunion model.Metatarsal diaphyseal defects (length: 10 or 20 mm) maintained with plates were performed in sheep in search of nonunion after a three-month period. Radiological and histological examinations showed that 10 mm gaps healed spontaneously while 20 mm gaps did not. These results are comparable to those of other authors who concluded that a diaphyseal defect whose length exceeds 1.4 times its diameter is unable to repair. The good biological properties exhibited by this defect model seem to be convenient for testing bone substitutes or bone healing enhancement techniques.

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