Preparation of Calcium Carbonate / Poly(lactic acid) Composite (CCPC) Hollow Spheres

2003 ◽  
Vol 254-256 ◽  
pp. 533-536 ◽  
Author(s):  
Hirotaka Maeda ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
Keyword(s):  
Lactic Acid ◽  
Calcium Carbonate ◽  
Hollow Spheres ◽  
Poly Lactic Acid

Preparation of poly(lactic acid) composites containing calcium carbonate (vaterite)

Biomaterials ◽  
2003 ◽  
Vol 24 (19) ◽  
pp. 3247-3253 ◽  
Author(s):  
Toshihiro Kasuga ◽  
Hirotaka Maeda ◽  
Katsuhito Kato ◽  
Masayuki Nogami ◽  
Ken-ichiro Hata ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Calcium Carbonate ◽  
Poly Lactic Acid

Preparation of Silica-Doped Poly(Lactic Acid) Composite Hollow Spheres Containing Calcium Carbonates

2006 ◽  
Vol 309-311 ◽  
pp. 457-460 ◽  
Author(s):  
Noriko Miura ◽  
Hirotaka Maeda ◽  
Toshihiro Kasuga
Keyword(s):  
Lactic Acid ◽  
Inductively Coupled Plasma ◽  
Hollow Spheres ◽  
Spherical Shape ◽  
Atomic Emission ◽  
Poly Lactic Acid ◽  
External Diameter ◽  
Calcium Carbonates ◽  
Inductively Coupled ◽  
A Cell

Silica-doped poly(lactic acid) (PLA) composite hollow spheres containing calcium carbonates (Si-CCPC spheres) were prepared using aminopropyltriethoxysilane (APTES) for injectable bone fillers combined with a cell-delivery system. Si-CCPC spheres have a hollow spherical shape of ~1 mm in the external diameter and an open channel in the shell, which is selfformed. The channel size is about 500 *m in diameter. X-ray energy dispersive spectroscopy (EDS) analysis showed incorporation of silicon in Si-CCPC spheres. After soaking Si-CCPC spheres in simulated body fluid (SBF), hydroxycarbonate apatite formed on the Si-CCPC spheres. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) showed that the Si4+ ion is released from Si-CCPC spheres in SBF.

Preparation of Poly(Lactic Acid) Composite Hollow Spheres with an Open Channel

2005 ◽  
Vol 284-286 ◽  
pp. 301-304 ◽  
Author(s):  
Hirotaka Maeda ◽  
Noriko Miura ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
Keyword(s):  
Lactic Acid ◽  
Open Channel ◽  
Hollow Spheres ◽  
Calcium Chloride Solution ◽  
Poly Lactic Acid ◽  
Cell Delivery ◽  
Calcium Carbonates ◽  
Apatite Coating ◽  
A Cell ◽  
Bonelike Apatite

Novel hollow spheres for bone fillers incorporating cells were prepared using composites consisting of poly(lactic acid) and calcium carbonates. An open channel of ~800 µm in diameter was easily formed using a chemical etching method to provide a pathway to the interior of the sphere. Cells could migrate through the open channel into the interior of the sphere. Bonelike apatite coating on the surface of the sphere was prepared by soaking in calcium chloride solution to supply excess Ca2+ ions on the surface and subsequently by soaking in simulated body fluid. The hollow spheres with an open channel may be one of the great potential candidates as novel bone fillers combined with a cell-delivery system.

Studies of poly(lactic acid) based calcium carbonate nanocomposites

2014 ◽  
Vol 56 ◽  
pp. 184-188 ◽  
Author(s):  
Vimal Kumar ◽  
Anshu Dev ◽  
A.P. Gupta
Keyword(s):  
Lactic Acid ◽  
Calcium Carbonate ◽  
Poly Lactic Acid
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