Preparation of Silica-Doped Poly(Lactic Acid) Composite Hollow Spheres Containing Calcium Carbonates

2006 ◽  
pp. 457-460
Author(s):  
Noriko Miura ◽  
Hirotaka Maeda ◽  
Toshihiro Kasuga
Keyword(s):  
Lactic Acid ◽  
Hollow Spheres ◽  
Poly Lactic Acid ◽  
Calcium Carbonates

Preparation of Silica-Doped Poly(Lactic Acid) Composite Hollow Spheres Containing Calcium Carbonates

2006 ◽  
Vol 309-311 ◽  
pp. 457-460 ◽  
Author(s):  
Noriko Miura ◽  
Hirotaka Maeda ◽  
Toshihiro Kasuga
Keyword(s):  
Lactic Acid ◽  
Inductively Coupled Plasma ◽  
Hollow Spheres ◽  
Spherical Shape ◽  
Atomic Emission ◽  
Poly Lactic Acid ◽  
External Diameter ◽  
Calcium Carbonates ◽  
Inductively Coupled ◽  
A Cell

Silica-doped poly(lactic acid) (PLA) composite hollow spheres containing calcium carbonates (Si-CCPC spheres) were prepared using aminopropyltriethoxysilane (APTES) for injectable bone fillers combined with a cell-delivery system. Si-CCPC spheres have a hollow spherical shape of ~1 mm in the external diameter and an open channel in the shell, which is selfformed. The channel size is about 500 *m in diameter. X-ray energy dispersive spectroscopy (EDS) analysis showed incorporation of silicon in Si-CCPC spheres. After soaking Si-CCPC spheres in simulated body fluid (SBF), hydroxycarbonate apatite formed on the Si-CCPC spheres. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) showed that the Si4+ ion is released from Si-CCPC spheres in SBF.

Preparation of Poly(Lactic Acid) Composite Hollow Spheres with an Open Channel

2005 ◽  
Vol 284-286 ◽  
pp. 301-304 ◽  
Author(s):  
Hirotaka Maeda ◽  
Noriko Miura ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
Keyword(s):  
Lactic Acid ◽  
Open Channel ◽  
Hollow Spheres ◽  
Calcium Chloride Solution ◽  
Poly Lactic Acid ◽  
Cell Delivery ◽  
Calcium Carbonates ◽  
Apatite Coating ◽  
A Cell ◽  
Bonelike Apatite

Novel hollow spheres for bone fillers incorporating cells were prepared using composites consisting of poly(lactic acid) and calcium carbonates. An open channel of ~800 µm in diameter was easily formed using a chemical etching method to provide a pathway to the interior of the sphere. Cells could migrate through the open channel into the interior of the sphere. Bonelike apatite coating on the surface of the sphere was prepared by soaking in calcium chloride solution to supply excess Ca2+ ions on the surface and subsequently by soaking in simulated body fluid. The hollow spheres with an open channel may be one of the great potential candidates as novel bone fillers combined with a cell-delivery system.

Biomimetic apatite formation on poly(lactic acid) composites containing calcium carbonates

2002 ◽  
Vol 17 (4) ◽  
pp. 727-730 ◽  
Author(s):  
Hirotaka Maeda ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami ◽  
Yoshitaka Hibino ◽  
Ken-Ichiro Hata ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Magic Angle Spinning ◽  
Poly Lactic Acid ◽  
Magic Angle ◽  
Apatite Formation ◽  
Composite Surface ◽  
Calcium Carbonates ◽  
Carbonation Process ◽  
Biomimetic Apatite ◽  
Angle Spinning

Poly(lactic acid) composites containing a mixture of calcium carbonates (vaterite, aragonite, and calcite) were prepared by a carbonation process in methanol. Soaking of the composites for 3 h in simulated body fluid (SBF) at 37 °C resulted in the deposition of bonelike apatite particles on the composite surface. After soaking the composites, vaterite phase in the composites was forward to dissolve rapidly, resulting in increase the supersaturation of the apatite in SBF. 13C cross-polarization magic angle spinning nuclear magnetic resonance (13C CP/MAS-NMR) spectra of the composites suggested the formation of a bond between Ca2+ ion and the COO- group, which induces the apatite nucleation. These results may elucidate the mechanism of means to reduce the induction period for apatite formation.

Preparation of Calcium Carbonate / Poly(lactic acid) Composite (CCPC) Hollow Spheres

2003 ◽  
Vol 254-256 ◽  
pp. 533-536 ◽  
Author(s):  
Hirotaka Maeda ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
Keyword(s):  
Lactic Acid ◽  
Calcium Carbonate ◽  
Hollow Spheres ◽  
Poly Lactic Acid

Preparation of Poly(L-lactic Acid) Hybrid Membrane with Silicon-Ion-Releasing Ability

2007 ◽  
Vol 330-332 ◽  
pp. 1305-1308 ◽  
Author(s):  
Hirotaka Maeda ◽  
Emile Hideki Ishida ◽  
Toshihiro Kasuga
Keyword(s):  
Heat Treatment ◽  
Cell Proliferation ◽  
Lactic Acid ◽  
Body Fluid ◽  
Cellular Proliferation ◽  
Hybrid Membrane ◽  
Poly Lactic Acid ◽  
Calcium Carbonates ◽  
Before And After ◽  
Proliferation Ability

A novel poly(lactic acid) (PLA)/calcium carbonates hybrid membrane containing siloxane was prepared using aminopropyltriethoxysilane (APTES) for biodegradable bone guided regeneration. The PLLA in the membrane was an amorphous phase. By heating the membrane at 100 °C for 1 h, the PLLA in the membrane crystallized. Numerous pores of 0.5-1 ,m in diameter were newly formed at the surface. After soaking the membranes before and after heat-treatment in simulated body fluid, the amount of silicon species in SBF released from the membrane after heat-treatment was higher than that before heat-treatment. A test of osteoblast-like cellular proliferation on the membrane showed the membrane after heat-treatment has much higher cell-proliferation ability than that before heat-treatment.

Apatite-Coated Poly(lactic acid) Composites with Cell-Compatibility Prepared by a Biomimetic Method

2006 ◽  
Vol 11-12 ◽  
pp. 239-242
Author(s):  
Hirotaka Maeda ◽  
Toshihiro Kasuga
Keyword(s):  
Lactic Acid ◽  
Bone Repair ◽  
Cellular Proliferation ◽  
Hybrid Membrane ◽  
Poly Lactic Acid ◽  
Calcium Carbonates ◽  
Cell Compatibility ◽  
Repair Materials ◽  
New Type ◽  
Bone Repair Materials

A new type of poly(lactic acid) (PLA)/calcium carbonates hybrid membrane incorporated with silicon, which is suggested to stimulate the formation of bones, was prepared using aminopropyltriethoxysilane (APTES) for bone repair materials. Carboxyl groups in PLA made a chemical bond with amino groups in APTES, resulting in the formation of the hybrid membrane. The membrane formed hydroxycarbonate apatite (HCA) on its surface after 3 days of soaking in simulated body fluid (SBF). X-ray energy dispersive spectroscopy showed the HCA layer includes Si with Ca and P. A result of osteoblast-like cellular proliferation on the substrates that the membrane coated with silicon-containing HCA had much higher cell-proliferation ability than the membrane.

Preparation of Poly(Lactic Acid) Composite Hollow Spheres with an Open Channel

2005 ◽  
pp. 301-304
Author(s):  
Hirotaka Maeda ◽  
Noriko Miura ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
Keyword(s):  
Lactic Acid ◽  
Open Channel ◽  
Hollow Spheres ◽  
Poly Lactic Acid
Sign in / Sign up

Export Citation Format

Share Document