Preparation of Poly(Lactic Acid) Composite Hollow Spheres with an Open Channel

2005 ◽  
Vol 284-286 ◽  
pp. 301-304 ◽  
Author(s):  
Hirotaka Maeda ◽  
Noriko Miura ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
Keyword(s):  
Lactic Acid ◽  
Open Channel ◽  
Hollow Spheres ◽  
Calcium Chloride Solution ◽  
Poly Lactic Acid ◽  
Cell Delivery ◽  
Calcium Carbonates ◽  
Apatite Coating ◽  
A Cell ◽  
Bonelike Apatite

Novel hollow spheres for bone fillers incorporating cells were prepared using composites consisting of poly(lactic acid) and calcium carbonates. An open channel of ~800 µm in diameter was easily formed using a chemical etching method to provide a pathway to the interior of the sphere. Cells could migrate through the open channel into the interior of the sphere. Bonelike apatite coating on the surface of the sphere was prepared by soaking in calcium chloride solution to supply excess Ca2+ ions on the surface and subsequently by soaking in simulated body fluid. The hollow spheres with an open channel may be one of the great potential candidates as novel bone fillers combined with a cell-delivery system.

Preparation of Silica-Doped Poly(Lactic Acid) Composite Hollow Spheres Containing Calcium Carbonates

2006 ◽  
Vol 309-311 ◽  
pp. 457-460 ◽  
Author(s):  
Noriko Miura ◽  
Hirotaka Maeda ◽  
Toshihiro Kasuga
Keyword(s):  
Lactic Acid ◽  
Inductively Coupled Plasma ◽  
Hollow Spheres ◽  
Spherical Shape ◽  
Atomic Emission ◽  
Poly Lactic Acid ◽  
External Diameter ◽  
Calcium Carbonates ◽  
Inductively Coupled ◽  
A Cell

Silica-doped poly(lactic acid) (PLA) composite hollow spheres containing calcium carbonates (Si-CCPC spheres) were prepared using aminopropyltriethoxysilane (APTES) for injectable bone fillers combined with a cell-delivery system. Si-CCPC spheres have a hollow spherical shape of ~1 mm in the external diameter and an open channel in the shell, which is selfformed. The channel size is about 500 *m in diameter. X-ray energy dispersive spectroscopy (EDS) analysis showed incorporation of silicon in Si-CCPC spheres. After soaking Si-CCPC spheres in simulated body fluid (SBF), hydroxycarbonate apatite formed on the Si-CCPC spheres. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) showed that the Si4+ ion is released from Si-CCPC spheres in SBF.

scholarly journals Bonelike Apatite Coating on Skeleton of Poly(lactic acid) Composite Sponge

2004 ◽  
Vol 45 (4) ◽  
pp. 989-993 ◽  
Author(s):  
Hirotaka Maeda ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
Keyword(s):  
Lactic Acid ◽  
Poly Lactic Acid ◽  
Apatite Coating ◽  
Bonelike Apatite

Preparation of Poly(Lactic Acid) Composite Hollow Spheres with an Open Channel

2005 ◽  
pp. 301-304
Author(s):  
Hirotaka Maeda ◽  
Noriko Miura ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
Keyword(s):  
Lactic Acid ◽  
Open Channel ◽  
Hollow Spheres ◽  
Poly Lactic Acid

Biomimetic apatite formation on poly(lactic acid) composites containing calcium carbonates

2002 ◽  
Vol 17 (4) ◽  
pp. 727-730 ◽  
Author(s):  
Hirotaka Maeda ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami ◽  
Yoshitaka Hibino ◽  
Ken-Ichiro Hata ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Magic Angle Spinning ◽  
Poly Lactic Acid ◽  
Magic Angle ◽  
Apatite Formation ◽  
Composite Surface ◽  
Calcium Carbonates ◽  
Carbonation Process ◽  
Biomimetic Apatite ◽  
Angle Spinning

Poly(lactic acid) composites containing a mixture of calcium carbonates (vaterite, aragonite, and calcite) were prepared by a carbonation process in methanol. Soaking of the composites for 3 h in simulated body fluid (SBF) at 37 °C resulted in the deposition of bonelike apatite particles on the composite surface. After soaking the composites, vaterite phase in the composites was forward to dissolve rapidly, resulting in increase the supersaturation of the apatite in SBF. 13C cross-polarization magic angle spinning nuclear magnetic resonance (13C CP/MAS-NMR) spectra of the composites suggested the formation of a bond between Ca2+ ion and the COO- group, which induces the apatite nucleation. These results may elucidate the mechanism of means to reduce the induction period for apatite formation.

Preparation of Silicon-Containing Poly(lactic acid)-Vaterite Hybrid Membranes

2010 ◽  
Vol 638-642 ◽  
pp. 670-674
Author(s):  
Akiko Obata ◽  
Takashi Wakita ◽  
Yoshio Ota ◽  
Toshihiro Kasuga
Keyword(s):  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Bone Regeneration ◽  
Trace Amount ◽  
Body Fluid ◽  
Poly Lactic Acid ◽  
Osteogenic Cells ◽  
A Cell ◽  
Silicon Doped ◽  
Gbr Membrane

Microfiber meshes releasing a trace amount of silicon species were prepared by electrospinning silicon-doped vaterite (SiV) and poly(lactic acid) (PLA) hybrids for application to membranes for guided bone regeneration (GBR). A trace amount of silicon-species has been reported to enhance the mineralization and bone-forming abilities of osteogenic cells. The microfiber meshes prepared by electrospinning are regarded to be a useful candidate for the GBR membrane, because they have adequate flexibility and porosity for it. In this study, hydroxyapatite (HA)-forming abilities in simulated body fluid, silicon-releasabilities, compatibility with osteoblast-like cells of the prepared microfiber meshes were examined. The meshes were completely coated with HA after soaking in simulated body fluid for 1 day. The meshes coated with HA released 0.2 -0.7 mg/L of silicon species in a cell culture medium for 7 days. The cells elongated on the microfibers of the meshes and some of them entered the mesh after 1 day-culturing. The meshes are expected to provide an excellent substrate for bone regeneration and enhance bone-forming ability of the cells.

Preparation of Calcium Carbonate / Poly(lactic acid) Composite (CCPC) Hollow Spheres

2003 ◽  
Vol 254-256 ◽  
pp. 533-536 ◽  
Author(s):  
Hirotaka Maeda ◽  
Toshihiro Kasuga ◽  
Masayuki Nogami
Keyword(s):  
Lactic Acid ◽  
Calcium Carbonate ◽  
Hollow Spheres ◽  
Poly Lactic Acid
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