17 Year Review of Hydroxyapatite Ceramic Coated Hip Implants – A Clinical and Histological Evaluation

2006 ◽  
Vol 309-311 ◽  
pp. 1341-1344 ◽  
Author(s):  
James M. Buchanan
Keyword(s):  
Histological Evaluation ◽  
Hip Implants ◽  
Hydroxyapatite Ceramic

scholarly journals Evaluation of hydroxyapatite ceramic vertebral spacers with different porosities and their binding capability to the vertebral body: an experimental study in sheep

2007 ◽  
Vol 6 (5) ◽  
pp. 431-437 ◽  
Author(s):  
Manabu Ito ◽  
Yoshihisa Kotani ◽  
Yoshihiro Hojo ◽  
Kuniyoshi Abumi ◽  
Tsuyoshi Kadosawa ◽  
...  
Keyword(s):  
Bone Ingrowth ◽  
Histological Study ◽  
Biomechanical Testing ◽  
Histological Evaluation ◽  
Micro Computed Tomography ◽  
Hydroxyapatite Ceramic ◽  
Sheep Model ◽  
Spinal Reconstruction ◽  
Computed Tomography Scans ◽  
The Ideal

Object The aim of this study was to evaluate the degree of bone ingrowth and bonding stiffness at the surface of hydroxyapatite ceramic (HAC) spacers with different porosities in an animal model and to discuss the ideal porous characteristics of these spacers for anterior spinal reconstruction. Methods Twenty-one adult sheep (age 1–2 years, mean weight 70 kg) were used in this experiment. Surgery consisted of anterior lumbar interbody fusion at L2–3 and L4–5, insertion of an HAC spacer (10 × 13 × 24 mm) with three different porosities (0, 3, and 15%), and single-rod anterior instrumentation. At 4 and 6 months postoperatively, the lumbar spines were harvested. Bonding conditions at the bone–HAC spacer interface were evaluated using neuroimages and biomechanically. A histological evaluation was also conducted to examine the state of bone ingrowth at the surface of the HAC spacer. Biomechanical testing showed that the bonding strength of HAC at 6 months postoperatively was 0.047 MPa in 0% porosity spacers, 0.39 MPa in 3%, and 0.49 MPa in 15% porosity spacers. The histological study showed that there was a soft-tissue layer at the surface of the HAC spacer with 0% porosity. Direct bonding was observed between bone and spacers with 3 or 15% porosity. Micro–computed tomography scans showed direct bonding between the bone and HAC with 3 or 15% porosity. No direct bonding was observed in HAC with 0% porosity. Conclusions Dense (0%) HAC anterior vertebral spacers did not achieve direct bonding to the bone in the sheep model. The HAC vertebral spacers with 3 or 15% porosity showed proof of direct bonding to the bone at 6 months postoperatively. The higher porosity HAC spacer showed better bonding stiffness to the bone.

Nineteen Years Review of Hydroxyapatite Ceramic Coated Hip Implants: A Clinical and Histological Evaluation

2007 ◽  
Vol 361-363 ◽  
pp. 1315-1318 ◽  
Author(s):  
James M. Buchanan ◽  
Sally Goodfellow
Keyword(s):  
Hip Arthroplasty ◽  
Hip Prosthesis ◽  
Histological Evaluation ◽  
Consecutive Series ◽  
Hydroxyapatite Ceramic ◽  
Bioactive Materials ◽  
Total Period ◽  
Cemented Arthroplasty ◽  
Wear Products ◽  
Cementing Techniques

The goal of hip arthroplasty is to restore the patient to an active and pain free life for ever. Unfortunately, prosthetic implants fail because of loosening, wear or infection. This study sets out to ascertain whether or not Hydroxyapatite hip arthroplasty (HA) will produce long-lasting function of at least ten years in unselected patients of all ages and all diagnoses. Cemented implants used in hip arthroplasty often loosen after ten or more years of use. This is partly mechanical but also associated with debris disease arising from plastic wear products. Cementing techniques have been improved and the Swedish Hip Register [1] demonstrates that the revision rates have been reduced with improved cementing techniques. Revision surgery after cemented arthroplasty is difficult and may be complicated by fracture of the host bone Bioactive materials are being used to secure joint implants [2,3] and this paper presents the results of a consecutive series of hip arthroplasties carried out over a total period of over 19 years using the Furlong Hydroxyapatite Ceramic Coated hip prosthesis.[4, 5]

16 Year Review of Hydroxyapatite Ceramic Coated Hip Implants - A Clinical and Histological Evaluation

2005 ◽  
Vol 284-286 ◽  
pp. 1049-1052 ◽  
Author(s):  
James M. Buchanan
Keyword(s):  
Hip Arthroplasty ◽  
Histological Evaluation ◽  
Harris Hip Score ◽  
Consecutive Series ◽  
Hydroxyapatite Ceramic ◽  
Bioactive Materials ◽  
Total Period ◽  
Pain Scores ◽  
Hip Arthroplasties ◽  
Cementing Techniques

Traditionally implants for hip arthroplasty are secured with bone cement. Problems have been encountered with cement fixation with loosening and osteolysis attributed to the reaction to particulate cement material and also polyethylene debris from wear. Cementing techniques have been improved and the Swedish Hip Register [1] demonstrates that the revision rates have been reduced with improved cementing techniques. However, uncemented hip arthroplasty is now having a revival. In particular, bioactive materials are being used and this paper presents the results of a consecutive series of hip arthroplasties carried out over a total period of just 16 years. All the patients are included, including primary and revision hip arthroplasty. Patients are assessed using the Harris Hip Score [2]. 13% of the hips scored less than 80 on the Harris Hip Score but only 9.4% scored poor pain scores. These represent the results of poor hip arthroplasty, of which an even smaller percentage are related to failed HA hip arthroplasty.

Histological evaluation of cochlear hair cell damage from noise-induced hearing loss in chinchillas

1990 ◽  
Vol 48 (3) ◽  
pp. 332-333
Author(s):  
R.V. Harrison ◽  
R.J. Mount ◽  
P. White ◽  
N. Fukushima
Keyword(s):  
Hair Cell ◽  
Evoked Potential ◽  
Cell Damage ◽  
Acoustic Trauma ◽  
Histological Evaluation ◽  
Cell Integrity ◽  
Functional Changes ◽  
Cochlear Hair Cell ◽  
Left And Right ◽  
Contralateral Ear

In studies which attempt to define the influence of various factors on recovery of hair cell integrity after acoustic trauma, an experimental and a control ear which initially have equal degrees of damage are required. With in a group of animals receiving an identical level of acoustic trauma there is more symmetry between the ears of each individual, in respect to function, than between animals. Figure 1 illustrates this, left and right cochlear evoked potential (CAP) audiograms are shown for two chinchillas receiving identical trauma. For this reason the contralateral ear is used as control.To compliment such functional evaluations we have devised a scoring system, based on the condition of hair cell stereocilia as revealed by scanning electron microscopy, which permits total stereociliar damage to be expressed numerically. This quantification permits correlation of the degree of structural pathology with functional changes. In this paper wereport experiments to verify the symmetry of stereociliar integrity between two ears, both for normal (non-exposed) animals and chinchillas in which each ear has received identical noise trauma.

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