Comparison among Four Kinds of Bone Tissue Engineering Scaffold

Bone tissue engineering is a promising way to repair of bone defects. To choose a proper scaffold is still a disputable problem in bone tissue engineering. This study aimed to compare the effects of repairing critical calvarial defects with the compounds of autogenous bone marrow stromal cells (BMSCs) and coral hydroxyapatite(CHA), hydroxyapatite/ tricalcium phosphate (HA/TCP), poly(lactide-co-glycolide) (PLGA) and alginate (AG). The results showed that CHA and AG were satisfactory bone tissues engineering scaffolds among the four kinds of materials. BMSCs/CHA and BMSCs/AG are promising techniques for reconstruction of bone defects.

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Reconstruction of Cranial Bone Defects Using a Compound of Bone Marrow Stromal Cells and Hydroxyapatite-Tricalcium Phosphate

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.368-372.1235 ◽

2008 ◽

Vol 368-372 ◽

pp. 1235-1237 ◽

Cited By ~ 1

Author(s):

Lei Liu ◽

Run Liang Chen ◽

Yun Feng Lin ◽

Wei Dong Tian ◽

Sheng Wei Li

Keyword(s):

Electron Microscopy ◽

Tissue Engineering ◽

Bone Marrow ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Stromal Cells ◽

Tricalcium Phosphate ◽

Bone Marrow Stromal Cells ◽

Bone Defects ◽

Marrow Stromal Cells

Hydroxyapatite-tricalcium phosphate (HA-TCP) is a new kind of material which shows good biocompatibility, biological degradability, and porosity. This study aimed to determine the effectiveness of HA-TCP as a bone tissue engineering scaffold. In this study, critical size cranial defects were reconstructed with compounds of autogenous bone marrow stromal cells (BMSCs) and HA-TCP. The resulting grafts were examined by X-ray, histological examination, semi-quantitative analysis of osteogenesis, immunochemical examination (collagen type I and III), scanning electron microscopy and transmission electron microscopy. The results showed that HA-TCP is a good bone tissue engineering scaffold and BMSCs/HA-TCP is a promising technique for reconstruction of bone defects.

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Graft Materials and Bone Marrow Stromal Cells in Bone Tissue Engineering

Journal of Biomaterials Applications ◽

10.1177/0885328210393046 ◽

2011 ◽

Vol 26 (8) ◽

pp. 1035-1049 ◽

Cited By ~ 6

Author(s):

Federico Foschi ◽

Enrico Conserva ◽

Paolo Pera ◽

Barbara Canciani ◽

Ranieri Cancedda ◽

...

Keyword(s):

Tissue Engineering ◽

Bone Marrow ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Stromal Cells ◽

Bone Marrow Stromal Cells ◽

Marrow Stromal Cells

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Comparative Study between Bone Tissue Engineering Scaffolds with Bull and Rat Cancellous Microarchitectures on Tissue Differentiations of Bone Marrow Stromal Cells: A Numerical Investigation

Journal of Bionic Engineering ◽

10.1007/s42235-018-0079-8 ◽

2018 ◽

Vol 15 (5) ◽

pp. 924-938

Author(s):

Xianbin Zhang ◽

He Gong ◽

Ruoxun Fan ◽

Juan Fang

Keyword(s):

Tissue Engineering ◽

Bone Marrow ◽

Comparative Study ◽

Bone Tissue Engineering ◽

Numerical Investigation ◽

Bone Tissue ◽

Stromal Cells ◽

Bone Marrow Stromal Cells ◽

Marrow Stromal Cells ◽

Tissue Engineering Scaffolds

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Comparison on the Osteogenesis Potential between Poly(lactide-Co-Glycolide) and Alginate as Bone Tissue Engineering Scaffold In Vivo

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.330-332.1173 ◽

2007 ◽

Vol 330-332 ◽

pp. 1173-1176 ◽

Cited By ~ 1

Author(s):

Cai Li ◽

Run Liang Chen ◽

Lei Liu ◽

Yun Feng Lin ◽

Wei Dong Tian ◽

...

Keyword(s):

Tissue Engineering ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Stromal Cells ◽

Bone Marrow Stromal Cells ◽

Three Dimensional ◽

Tissue Engineering Scaffold ◽

Autogenous Bone ◽

Mechanical Characters

Poly(lactide-co-glycolide) (PLGA) and alginate(AG) are the most promising scaffolds in the bone tissue engineering for their stable mechanical characters and three-dimensional porous structure. This study aimed to assay the in vivo osteogenesis potentials by loading the autogenous bone marrow stromal cells (BMSCs) on PLGA or AG. The results suggested that PLGA and AG are both ideal bone tissue engineering scaffold. BMSCs/AG has stronger osteogenesis potentials in vivo than BMSCs/PLGA.

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