scholarly journals Synthesis of derivatives of β-sitosterol and evaluation of their anti-bacterial activity

2021 ◽  
Vol 50 (4) ◽  
pp. 497
Author(s):  
L. A. M. Fernando ◽  
W. G. D. Wickramasingha ◽  
S. Jayasinghe
Author(s):  
Megha Shukla ◽  
Sumeet Kaur Bhatia ◽  
Balbir Kaur

This research article describes the synthesis of phenyl hydrazone derivatives of 5-acetyl-6-methyl-4-substituted phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidines, as no derivatization has been reported at carbonyl functionality at position 5 of corresponding rings till date. The prepared derivatives were characterised using modern spectral techniques and were screened for their in-vitro anti-microbial activities by agar diffusion method. Among synthesised derivatives [II(a-g)], compound II(f) was found to be the most potent anti-bacterial agent and rest of the compounds had shown moderate to weak anti-bacterial activity.


2002 ◽  
Vol 57 (7-8) ◽  
pp. 614-619 ◽  
Author(s):  
Christian Zidorn ◽  
Renate Spitaler ◽  
Ernst-P. Ellmerer-Müller ◽  
Nigel B. Perry ◽  
Clarissa Gerhäuser ◽  
...  

A novel tyrolobibenzyl derivative, 1→6-β-ᴅ-apiosyl-β-ᴅ-glucopyranosyl 4-[2-(4-hydroxyphenyl) ethyl]benzofuran-2-carboxylate 3 (tyrolobibenzyl D) was isolated from Scorzonera humilis L. and its structure established by mass spectrometry and 1D- and 2D-NMR spectroscopy. The biological activities of the new compound and related tyrolobibenzyls A-C (1-2, 4) and the semi-synthetic peracetyl derivatives of tyrolobibenzyls B (2a) and C (4a) were assessed. The results revealed no cytotoxic activity against P388 cells and neither anti-bacterial activity against Bacillus subtilis nor antifungal activity against Candida albicans and Trichophyton mentagrophytes for any of the investigated compounds. An evaluation of potential chemopreventive activity of 2, 2a, 4, and 4a also revealed no pronounced activity in any of the employed assaying systems.


1982 ◽  
Vol 85 (1) ◽  
pp. 257-263 ◽  
Author(s):  
A. Graja ◽  
M. Przybylski ◽  
B. Butka ◽  
R. Swietlik

2002 ◽  
Vol 23 (2) ◽  
pp. 125-207 ◽  
Author(s):  
Igor D. Sadekov ◽  
Alexander V. Zakharov ◽  
Alexander A. Maksimenko
Keyword(s):  

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