scholarly journals Hypothyroidism as a cause for nephrotic syndrome: Two case reports

2021 ◽  
Vol 26 (1) ◽  
pp. 45
Author(s):  
A. Amarasinghe ◽  
J. Jayawardane ◽  
H. Jayawardhana ◽  
A. Jayanaga
Keyword(s):  
Nephrotic Syndrome ◽  
Case Reports

Percutaneous transcatheter renal embolization with absolute ethanol for uncontrolled nephrotic syndrome: Case reports

2001 ◽  
Vol 42 (1) ◽  
pp. 80-83 ◽  
Author(s):  
T. Tikkakoski ◽  
M. Leppänen ◽  
J. Turunen ◽  
S. Anderson ◽  
H. Södervik
Keyword(s):  
Nephrotic Syndrome ◽  
Case Reports ◽  
Absolute Ethanol ◽  
Renal Embolization

scholarly journals Case Report: Lenalidomide as a Second-Line Treatment for Bortezomib-Ineffective Nephrotic Syndrome Caused by LCDD: 2 Case Reports and a Literature Review

2021 ◽  
Vol 8 ◽  
Author(s):  
Xin Zhang ◽  
Xiao-juan Yu ◽  
Su-xia Wang ◽  
Fu-de Zhou ◽  
Ming-hui Zhao
Keyword(s):  
Nephrotic Syndrome ◽  
Light Chain ◽  
Case Reports ◽  
Light Chain Deposition Disease ◽  
First Line Therapy ◽  
Hematological Response ◽  
Systemic Disorder ◽  
Light Chain Deposition ◽  
Stage Renal Disease ◽  
End Stage

Background: Light-chain deposition disease (LCDD) is a rare systemic disorder characterized by the deposition of monoclonal light chains in organs. The kidney is a prominent target of light-chain deposition, with a median time to end-stage renal disease (ESRD) of 2.7 years and 5-year ESRD-free survival of 37%. The therapeutic management of LCDD remains ill-defined. In addition to bortezomib-based therapy as first-line therapy, the effect of lenalidomide on LCDD is rarely reported.Case Presentation: This study describes two male LCDD patients in their 60s with nephrotic syndrome and moderately impaired renal function. One patient had monoclonal IgGλ with underlying MGRS, and another had monoclonal IgGκ with underlying monoclonal gammopathy that developed into symptomatic MM during follow-up. The hallmarks of this disease were consistent with previous reports. Both patients initially received BCD therapy, but no hematological response was observed. Consequently, the nephrotic syndrome was refractory. Sequential Rd therapy was initiated, and partial hematological response and nephrotic remission were observed in the IgGλ patient but absent in the IgGκ patient.Conclusion: Limited reports have demonstrated the effect of lenalidomide in LCDD. We report the outcome of lenalidomide in two cases of bortezomib-resistant LCDD. This treatment might be a beneficial supplement for those unresponsive or intolerant to bortezomib in LCDD, but the effect should be prospectively investigated.

scholarly journals Acute abdominal pain and nephrotic syndrome: pediatric case reports and review of the literature

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Giovanni Conti ◽  
Nicolina Stefania Carucci ◽  
Valentina Comito ◽  
Pietro Impellizzeri ◽  
Carmela Visalli ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Abdominal Pain ◽  
Acute Abdominal Pain ◽  
Case Reports ◽  
Team Approach ◽  
Pediatric Case ◽  
Correct Treatment ◽  
Spontaneous Reduction ◽  
Primary Peritonitis ◽  
First Case

Abstract Background Acute abdominal pain in nephrotic syndrome (NS) is a well-known clinical symptom and is mainly related to peritonitis. The presence, although rare, of red umbilicus may guide the diagnosis as a suggestive sign of peritonitis also in the non-neonatal period. Instead, the association between intussusception and NS is quite limited. We reviewed all published cases in the literature, and to our knowledge, this is one of the few pediatric cases of spontaneous resolution of intussusception in the setting of NS. Finally, a review of the causes of abdominal pain during the course of NS was made. Cases presentation We report two pediatric patient cases who complained of acute abdominal pain during a relapse episode of their NS. The first case is a 4-year-old boy with NS (fourth relapse) who presented with acute abdominal pain, ascites, and red umbilicus. Our suspect of primary peritonitis was clinically confirmed because of the subsequent appearance of the classical peritoneal signs. The second case is a 4-year-old boy who developed an ileo-ileal intussusception during the treatment of his first NS relapse, with spontaneous reduction. Conclusions Gastrointestinal disorders are frequently encountered in the course of NS. The appearance of acute abdominal pain in children with NS requires quick management, both clinical and instrumental. A multidisciplinary team approach needs to be encouraged to lead to an accurate diagnosis and a correct treatment.

scholarly journals Collapsing focal segmental glomerulosclerosis probably triggered by dengue virus infection - two case reports

2020 ◽  
Author(s):  
Patrícia Cruz Queiroz ◽  
Ana Elisa Souza Jorge ◽  
Plínio Henrique Vaz Mourão ◽  
Maria Goretti Moreira Guimarães Penido
Keyword(s):  
Renal Function ◽  
Nephrotic Syndrome ◽  
Virus Infection ◽  
Dengue Virus ◽  
Focal Segmental Glomerulosclerosis ◽  
Case Reports ◽  
Kidney Injury ◽  
Dengue Virus Infection ◽  
Segmental Glomerulosclerosis ◽  
Collapsing Fsgs

Abstract The reported cases describe the association between collapsing focal segmental glomerulosclerosis (FSGS) and acute dengue virus infection. In both cases, patients were diagnosed with dengue virus infection and had a severe kidney disease, with nephrotic syndrome and acute kidney injury. Kidney biopsy was performed and showed collapsing FSGS. The first patient, a 27-year-old man, was diagnosed with dengue virus infection and developed nephrotic syndrome after two weeks of illness. He was treated with methylprednisolone for three days and intravenous furosemide. This patient evolved well, although his renal function did not fully recover. The second patient, a 32-year-old man, was diagnosed with a milder clinical presentation of dengue virus infection. He had a past medical history of nephrotic syndrome in childhood, which might have caused its relapse. This patient was treated with intravenous furosemide and also did not fully recover renal function. These cases highlight the possible implication of dengue virus infection in the etiology of collapsing variant of FSGS. Healthcare professionals should be prepared to identify similar cases.

scholarly journals Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Vânia Benido Silva ◽  
Maria Teresa Pereira ◽  
Carla Leal Moreira ◽  
Sílvia Santos Monteiro ◽  
Isabel Inácio ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Thyroid Function ◽  
Early Stage ◽  
Case Reports ◽  
Overt Hypothyroidism ◽  
Newly Diagnosed ◽  
Bilateral Nephrectomy ◽  
Normal Thyroid ◽  
Normal Thyroid Function ◽  
High Prevalence

Nephrotic syndrome may trigger the onset of hypothyroidism, promoting massive urinary protein losses including thyroxine (T4) and triiodothyronine (T3) along with their binding proteins. At an early stage, a clinical and biochemical euthyroid state is expected. However, in patients with prolonged and severe proteinuria, especially with concomitant low thyroid reserve, urinary losses of free and protein-bound thyroid hormones are sufficiently pronounced to induce a subclinical or overt hypothyroidism. Despite its high prevalence in clinical practice, the literature lacks case reports of newly diagnosed clinical hypothyroidism due to NS in adults, making this condition under-recognized. We report a case of a 23-year-old man with previous normal thyroid function who developed overt hypothyroidism due to a severe nephrotic syndrome, requiring supplementation with levothyroxine (LT). After the patient had undergone bilateral nephrectomy, treatment with LT was discontinued and thyroid function normalized.

scholarly journals A Case of Nephrotic Syndrome that Resolved with Influenza B Infection

2021 ◽  
Vol 11 (1) ◽  
pp. 103-109
Author(s):  
Hiroshi Tamura ◽  
Shohei Kuraoka ◽  
Yuko Hidaka ◽  
Hiroko Nagata ◽  
Keishiro Furuie ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Virus Infection ◽  
Measles Virus ◽  
Case Reports ◽  
Spontaneous Remission ◽  
Japanese Woman ◽  
Influenza B Virus ◽  
Influenza B ◽  
High Power Field ◽  
Short Period

It has been postulated that measles virus infection is associated with remission of idiopathic nephrotic syndrome (INS) in childhood. There are few reports on the correlation of INS remission with other infections. Previously, there have been two case reports suggesting an association between influenza B virus infection and the remission of INS. The patient was an 18-year-old Japanese woman. The onset of steroid-sensitive NS was at 9 years of age, and pathological diagnosis was minimal change nephrotic syndrome (MCNS). Until 10 months prior to visiting our hospital, the patient’s NS was in remission. The patient experienced fever, cough, and malaise and she was diagnosed with type B influenza by a local physician 4 days before visiting our hospital. The patient had vomiting and diarrhea 1 day prior to visiting our hospital. Her weight was 54.7 kg (+5.0 kg) and she had pitting edema of both lower legs. Her serum albumin level was 0.9 g/dL, proteinuria level was 8.73 g/gCr, and urine sediments showed 1–4 red blood cells per high-power field. She was diagnosed with relapse of NS. The level of proteinuria decreased to 0.03 g/gCr with rest alone on day 4 of admission, and a complete remission from NS was observed at approximately 2 weeks after the onset of influenza B infection. We report a rare case wherein spontaneous remission of NS occurred within a short period of 2 weeks after influenza B infection. It is clear that some immunity is involved in the pathogenesis of INS, but there are some cases in which infection improves NS and others in which it recurs.

scholarly journals Nephrotic Syndrome in a Multiple Sclerosis Patient Treated with Interferon β1a

2005 ◽  
Vol 32 (3) ◽  
pp. 366-368 ◽  
Author(s):  
Anthony Auty ◽  
Abdulkarim Saleh
Keyword(s):  
Multiple Sclerosis ◽  
Nephrotic Syndrome ◽  
Case Reports ◽  
Immunosuppressive Treatment ◽  
Membranous Glomerulonephritis ◽  
Severe Case ◽  
Protein Loss ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

ABSTRACT:Background:Interferon β has become standard therapy for reducing relapse frequency in relapsing/remitting Multiple Sclerosis (RRMS). Several different preparations are available including interferon β1a (Avonex, Rebif) and interferon β1b (Betaferon/Betaseron). For the most part these preparations have been considered safe. Recently there have been concerns relating to liver1 and now kidney toxicity.Case Report:We present a case of a 28-yr old male who developed a severe case of nephrotic syndrome while being treated for relapsing/remitting Multiple Sclerosis (RRMS) with weekly injections of interferon β1a.Subsequent course:The nephrosis resolved almost completely once the interferon was stopped and after immunosuppressive treatment. At its peak the daily protein loss was 35.82 g. Kidney biopsy demonstrated membranous glomerulonephritis.Discussion:Two other case reports of nephrotic syndrome have been reported in the literature. This latest (third) report suggests that the safety profile should be reexamined and at least raises the question of potential renal toxicity of interferons in MS.

PERCUTANEOUS TRANSCATHETER RENAL EMBOLIZATION WITH ABSOLUTE ETHANOL FOR UNCONTROLLED NEPHROTIC SYNDROME. Case reports

2001 ◽  
Vol 42 (1) ◽  
pp. 80-83 ◽  
Author(s):  
T. Tikkakoski ◽  
M. Leppanen ◽  
J. Turunen ◽  
S. Anderson ◽  
H. Sodervik
Keyword(s):  
Nephrotic Syndrome ◽  
Case Reports ◽  
Absolute Ethanol ◽  
Renal Embolization
Sign in / Sign up

Export Citation Format

Share Document