scholarly journals A Randomized Controlled Trial for Doing vs. Omitting Intraoperative Frozen Section Biopsy for Resection Margin Status in Selected Patients Undergoing Breast-Conserving Surgery (OFF-MAP Trial)

2021 ◽  
Vol 24 ◽  
Author(s):  
Tae-Kyung Yoo ◽  
Young-Joon Kang ◽  
Joon Jeong ◽  
Jeong-Yoon Song ◽  
Sun Hee Kang ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Resection Margin ◽  
Frozen Section ◽  
Controlled Trial ◽  
Breast Conserving Surgery ◽  
Margin Status ◽  
Intraoperative Frozen Section ◽  
Randomized Controlled ◽  
Resection Margin Status

scholarly journals The Impact of Intraoperative Frozen Section on Resection Margin Status and Survival of Patients Underwent Pancreatoduodenectomy for Distal Cholangiocarcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhiqiang Chen ◽  
Bingran Yu ◽  
Jiaping Bai ◽  
Qiong Li ◽  
Bowen Xu ◽  
...  
Keyword(s):  
Median Survival ◽  
Statistical Difference ◽  
Resection Margin ◽  
Frozen Section ◽  
Margin Status ◽  
R0 Resection ◽  
Distal Cholangiocarcinoma ◽  
Intraoperative Frozen Section ◽  
Resection Margin Status ◽  
The Impact

BackgroundIntraoperative frozen section (FS) is broadly used during pancreaticoduodenectomy (PD) to ensure a negative margin status, but its survival benefits on obtaining a secondary R0 resection for distal cholangiocarcinoma (dCCA) is controversial and unclear.MethodsClinical data of 107 patients who underwent PD for dCCA was retrospectively collected and divided into different groups based on use of FS (FS and non-FS groups) and status of resection margin (pR0, sR0 and R1 groups), and clinical parameters and survival of patients were compared and analyzed accordingly.ResultsThere were 50 patients in FS group with a median survival of 28 months, 57 patients in non-FS group with a median survival of 27 months. There was no statistical difference between the two groups with Kaplan-Meier survival analysis (P = 0.347). There were 98 patients in R0 group (88 in pR0 and 10 in sR0) and nine patients in R1 group, with a median survival of 29 months and 22 months respectively, which showed a better survival in R0 group than in R1 group (P = 0.006). Survival analyses between subgroups revealed difference between pR0 and R1 group (P = 0.005), while no statistical difference concerning pR0 vs. sR0 (P = 0.211) and sR0 vs. R1 groups (P = 0.262). Multivariate Cox regression analysis revealed resection margin status, pre-operative biliary drainage and lymph node invasion to be independent prognostic factors for dCCA patients.ConclusionsIntraoperative FS should be recommended as it significantly increased the rate of R0 resection, which was positively related to a better survival. A primary R0 resection should also be encouraged and if not, a secondary R0 could be considered at the discretion of surgeons as it showed similar survival with primary R0 resection.

Circumferential Shaving of the Cavity in Breast-Conserving Surgery: A Randomized Controlled Trial

2019 ◽  
Vol 26 (13) ◽  
pp. 4256-4263 ◽  
Author(s):  
Kai Chen ◽  
Liling Zhu ◽  
Lili Chen ◽  
Qian Li ◽  
Shunrong Li ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Breast Conserving Surgery ◽  
Randomized Controlled

Robotic vs. laparoscopic vs. open abdominoperineal resection for low rectal cancer: Short-term outcomes of a single-center prospective randomized controlled trial.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 3603-3603 ◽  
Author(s):  
Ye Wei ◽  
Jianmin Xu ◽  
Li Ren ◽  
Qingyang Feng ◽  
Guodong He ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Rectal Cancer ◽  
Randomized Controlled Trial ◽  
Complication Rate ◽  
Open Surgery ◽  
Resection Margin ◽  
Controlled Trial ◽  
Low Rectal Cancer ◽  
Postoperative Complication Rate ◽  
Randomized Controlled

3603 Background: Currently, robotic surgery for rectal cancer using da Vinci System is common. However, there is almost no clinical trial reported. This randomized controlled trial aims to compare the safety and efficacy of robotic, laparoscopic and open abdominoperineal resection (APR) for low rectal cancer. Methods: From September 2013 to August 2016, patients aged from 18 to 75 years, with low rectal cancer within 5 cm from anal verge, clinical T1 to T3, no distant metastases, were randomly assigned to receive either robotic procedures (RAP), laparoscopic procedures (LAP) or open surgery (OS) for APR in 1:1:1 ratio. The primary endpoint was postoperative complication rate. This study is registered with ClinicalTrials.gov (NCT01985698). Results: Totally 406 patients were randomly assigned. Actually, 135 finished RAP, 131 finished LAP, and 137 finished OS (including 4 convert from LAP to OS). RAP had significantly lower postoperative complication rate (11.1%) than both LAP (21.4%, P = 0.023) and OS (27.7%, P = 0.001). Also, RAP reduced intraoperative hemorrhage (median [interquartile range], 100 [90-110] ml) than LAP (130 [100-150] ml, P < 0.001) and OS (150 [120-260] ml, P < 0.001). And RAP promoted postoperative recovery, with shorter days to first flatus (1.0 [1.0-2.0] day) than LAP (2.0 [2.0-3.0] day, P < 0.001) and OS (3.0 [2.0-4.0] day, P < 0.001), shorter days to first automatic urination (2.0 [2.0-3.0] day) than LAP (3.0 [2.0-4.0] day, P < 0.001) and OS (3.0 [2.0-4.0] day, P < 0.001), and shorter days to discharge (5.0 [5.0-6.0] days) than LAP (6.0 [5.0-7.0] days, P < 0.001) and OS (6.0 [5.0-7.0] day, P = 0.005). There was no significant difference in open conversion rate, resection margin involvement (including circumferential resection margin), number of lymph node harvested and pathological tumor stage. Conclusions: Robotic APR was safer, and reproduce equivalent surgical quality of conventional laparoscopic and open surgery. Also, it provided less injury and faster functional recovery. Clinical trial information: NCT01985698.

Erector Spinae Plane Block Versus Serratus Plane Block in Breast Conserving Surgery: Α Randomized Controlled Trial

2021 ◽  
Vol 41 (11) ◽  
pp. 5667-5676
Author(s):  
GIANLUCA VANNI ◽  
GIORDANA CAIAZZA ◽  
MARCO MATERAZZO ◽  
GENEROSO STORTI ◽  
MARCO PELLICCIARO ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Breast Conserving Surgery ◽  
Erector Spinae ◽  
Randomized Controlled ◽  
Erector Spinae Plane Block
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