scholarly journals Differential Features of AIRE-Induced and AIRE-Independent Promiscuous Gene Expression in Thymic Epithelial Cells

2015 ◽  
Vol 195 (2) ◽  
pp. 498-506 ◽  
Author(s):  
Charles St-Pierre ◽  
Assya Trofimov ◽  
Sylvie Brochu ◽  
Sébastien Lemieux ◽  
Claude Perreault
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Thymic Epithelial Cells ◽  
Promiscuous Gene Expression

scholarly journals Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Fatima Dhalla ◽  
Jeanette Baran‐Gale ◽  
Stefano Maio ◽  
Lia Chappell ◽  
Georg A Holländer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Thymic Epithelial Cells ◽  
Medullary Thymic Epithelial Cells ◽  
Promiscuous Gene Expression

Evidence for a network transcriptional control of promiscuous gene expression in medullary thymic epithelial cells

2009 ◽  
Vol 46 (16) ◽  
pp. 3240-3244 ◽  
Author(s):  
Cláudia Macedo ◽  
Adriane F. Evangelista ◽  
Danielle A. Magalhães ◽  
Thaís A. Fornari ◽  
Leandra L. Linhares ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Transcriptional Control ◽  
Thymic Epithelial Cells ◽  
Medullary Thymic Epithelial Cells ◽  
Promiscuous Gene Expression

scholarly journals Contrasting models of promiscuous gene expression by thymic epithelium

2005 ◽  
Vol 202 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Geoffrey O. Gillard ◽  
Andrew G. Farr
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Broad Spectrum ◽  
Alternative Model ◽  
Thymic Epithelial Cells ◽  
Central Tolerance ◽  
Thymic Epithelium ◽  
Medullary Thymic Epithelial Cells ◽  
Promiscuous Gene Expression ◽  
Self Antigens

Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed here, an alternative model—whereby TRA expression is regulated by conserved developmental programs active in developing mTECs—may be equally plausible.

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

10.1038/ni723 ◽  
2001 ◽  
Vol 2 (11) ◽  
pp. 1032-1039 ◽  
Author(s):  
Jens Derbinski ◽  
Antje Schulte ◽  
Bruno Kyewski ◽  
Ludger Klein
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Thymic Epithelial Cells ◽  
Medullary Thymic Epithelial Cells ◽  
Promiscuous Gene Expression
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