scholarly journals Early Growth Response (Egr)-1 Gene Induction in the Thymus in Response to TCR Ligation During Early Steps in Positive Selection Is Not Required for CD8 Lineage Commitment

2000 ◽  
Vol 165 (5) ◽  
pp. 2444-2450 ◽  
Author(s):  
M. Albert Basson ◽  
Timothy J. Wilson ◽  
Giuseppe A. Legname ◽  
Nitza Sarner ◽  
Peter D. Tomlinson ◽  
...  
Keyword(s):  
Positive Selection ◽  
Growth Response ◽  
Gene Induction ◽  
Early Growth ◽  
Lineage Commitment ◽  
Early Growth Response

scholarly journals Induction of the Early Growth Response (Egr) Family of Transcription Factors during Thymic Selection

1997 ◽  
Vol 185 (4) ◽  
pp. 731-744 ◽  
Author(s):  
Hui Shao ◽  
Dwight H. Kono ◽  
Ling-Yu Chen ◽  
Elyssa M. Rubin ◽  
Jonathan Kaye
Keyword(s):  
Positive Selection ◽  
Cell Line ◽  
Growth Response ◽  
Regulation Of Gene Expression ◽  
Early Growth ◽  
Double Positive ◽  
Early Growth Response ◽  
Precursor Cell Line ◽  
Single Positive ◽  
High Level

There is little known about the regulation of gene expression during TCR-mediated differentiation of immature CD4+8+ (double positive) thymocytes into mature T cells. Using the DPK CD4+8+thymocyte precursor cell line, we demonstrate that the early growth response-1 gene (Erg-1), encoding a zinc finger transcription factor, is rapidly upregulated after TCR stimulation. We also report that Egr-1 is expressed by a subset of normal double positive thymocytes in the thymic cortex, as well by a majority of medullary single positive thymocytes. Expression of Egr-1 is dramatically reduced in the thymus of major histocompatibility complex knockout mice, but can be induced by anti-CD3 antibody stimulation of isolated thymocytes from these animals. These and other data suggest that high level expression of Egr-1 in the thymus is a consequence of selection. A similar pattern of expression is found for family members Egr-2 and Egr-3. Using the DPK cell line, we also demonstrate that expression of Egr-1, 2, and 3 is dependent upon ras activation, as is the initiation of differentiation to a single positive cell. In contrast, the calcineurin inhibitor cyclosporin A, which inhibits DPK cell differentiation as well as positive selection, inhibits expression of Egr-2 and Egr-3, but not Egr-1. The identification of the Egr family in this context represents the first report of a link between the two known signaling pathways involved in positive selection and downstream transcriptional regulators.

scholarly journals Early growth response 2 regulates the survival of thymocytes during positive selection

2009 ◽  
Vol 40 (1) ◽  
pp. 232-241 ◽  
Author(s):  
Victoria J. Lawson ◽  
Kathleen Weston ◽  
Diane Maurice
Keyword(s):  
Positive Selection ◽  
Growth Response ◽  
Early Growth ◽  
Early Growth Response

Bone Marrow Mesenchymal Stem Cell mediated Ultrasmall Gold Nanoclusters and hNIS Gene Synergize Radiotherapy in Breast Cancer

2021 ◽  
Author(s):  
Lu Zhang ◽  
Benchao Zheng ◽  
Rui Guo ◽  
Ying Miao ◽  
Biao Li
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Stem Cell ◽  
Growth Response ◽  
Sodium Iodide ◽  
Gold Nanoclusters ◽  
Early Growth ◽  
Sodium Iodide Symporter ◽  
Early Growth Response ◽  
131I Treatment

The human sodium iodide symporter (hNIS) can be linked to the downstream of radiation-sensitive early growth response protein1 (Egr1) promoter, and activated by the Egr1 following 131I treatment. However, the...

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