scholarly journals Highly Activated CD8+T Cells in the Brain Correlate with Early Central Nervous System Dysfunction in Simian Immunodeficiency Virus Infection

2001 ◽  
Vol 167 (9) ◽  
pp. 5429-5438 ◽  
Author(s):  
Maria Cecilia Garibaldi Marcondes ◽  
E. M. E. Burudi ◽  
Salvador Huitron-Resendiz ◽  
Manuel Sanchez-Alavez ◽  
Debbie Watry ◽  
...  
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Virus Infection ◽  
Simian Immunodeficiency Virus ◽  
Cd8 T Cells ◽  
Simian Immunodeficiency Virus Infection ◽  
Central Nervous System Dysfunction ◽  
Immunodeficiency Virus ◽  
The Brain

Central Nervous System Correlates of Behavioral Deficits Following Simian Immunodeficiency Virus Infection

2003 ◽  
Vol 9 (4) ◽  
pp. 452-464 ◽  
Author(s):  
Michael R Weed ◽  
Robert D Hienz ◽  
Joseph V Brady ◽  
Robert J Adams ◽  
Joseph L Mankowski ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Virus Infection ◽  
Simian Immunodeficiency Virus ◽  
Simian Immunodeficiency Virus Infection ◽  
Behavioral Deficits ◽  
Immunodeficiency Virus

Simian Immunodeficiency Virus Infection of CD4+CD8+T Cells in a Macaque with an Unusually High Peripheral CD4+CD8+T Lymphocyte Count

2003 ◽  
Vol 19 (4) ◽  
pp. 267-274 ◽  
Author(s):  
Emmanuel Khatissian ◽  
Valérie Monceaux ◽  
Marie-Christine Cumont ◽  
Raphaël Ho Tsong Fang ◽  
Jérôme Estaquier ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Simian Immunodeficiency Virus ◽  
T Lymphocyte ◽  
Cd8 T Cells ◽  
Lymphocyte Count ◽  
Simian Immunodeficiency Virus Infection ◽  
Cd8 T Lymphocyte ◽  
Immunodeficiency Virus

scholarly journals High Frequency of Virus-Specific CD8+ T Cells in the Central Nervous System of Macaques Chronically Infected with Simian Immunodeficiency Virus SIVmac251

2003 ◽  
Vol 77 (22) ◽  
pp. 12346-12351 ◽  
Author(s):  
Marcin Moniuszko ◽  
Charlie Brown ◽  
Ranajit Pal ◽  
Elzbieta Tryniszewska ◽  
Wen-Po Tsai ◽  
...  
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Simian Immunodeficiency Virus ◽  
Rhesus Macaques ◽  
Specific Response ◽  
Immunodeficiency Virus ◽  
The Central Nervous System ◽  
The Brain

ABSTRACT Infection with human immunodeficiency virus or simian immunodeficiency virus (SIV) induces virus-specific CD8+ T cells that traffic to lymphoid and nonlymphoid tissues. In this study, we used Gag-specific tetramer staining to investigate the frequency of CD8+ T cells in peripheral blood and the central nervous system of Mamu-A*01-positive SIV-infected rhesus macaques. Most of these infected macaques were vaccinated prior to SIVmac251 exposure. The frequency of Gag181-189 CM9 tetramer-positive cells was consistently higher in the cerebrospinal fluid and the brain than in the blood of all animals studied and did not correlate with either plasma viremia or CD4+-T-cell level. Little or no infection in the brain was documented for most animals by nucleic acid sequence-based amplification or in situ hybridization. These data suggest that this Gag-specific response may contribute to the containment of viral replication in this locale.

scholarly journals CD8+T Cells Maintain Suppression of Simian Immunodeficiency Virus in the Central Nervous System

2014 ◽  
Vol 211 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Maria Cecilia G. Marcondes ◽  
Brenda Morsey ◽  
Katy Emanuel ◽  
Benjamin G. Lamberty ◽  
Claudia T. Flynn ◽  
...  
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Simian Immunodeficiency Virus ◽  
Cd8 T Cells ◽  
Immunodeficiency Virus ◽  
The Central Nervous System
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