scholarly journals Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system

2013 ◽  
Vol 6 (1) ◽  
pp. 40 ◽  
Author(s):  
Jonathan Liu ◽  
Jeanne M Sisk ◽  
Lucio Gama ◽  
Janice E Clements ◽  
Kenneth W Witwer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Virus Infection ◽  
Simian Immunodeficiency Virus ◽  
Simian Immunodeficiency Virus Infection ◽  
Immunodeficiency Virus ◽  
The Central Nervous System

Central Nervous System Correlates of Behavioral Deficits Following Simian Immunodeficiency Virus Infection

2003 ◽  
Vol 9 (4) ◽  
pp. 452-464 ◽  
Author(s):  
Michael R Weed ◽  
Robert D Hienz ◽  
Joseph V Brady ◽  
Robert J Adams ◽  
Joseph L Mankowski ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Virus Infection ◽  
Simian Immunodeficiency Virus ◽  
Simian Immunodeficiency Virus Infection ◽  
Behavioral Deficits ◽  
Immunodeficiency Virus

scholarly journals Highly Activated CD8+T Cells in the Brain Correlate with Early Central Nervous System Dysfunction in Simian Immunodeficiency Virus Infection

2001 ◽  
Vol 167 (9) ◽  
pp. 5429-5438 ◽  
Author(s):  
Maria Cecilia Garibaldi Marcondes ◽  
E. M. E. Burudi ◽  
Salvador Huitron-Resendiz ◽  
Manuel Sanchez-Alavez ◽  
Debbie Watry ◽  
...  
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Virus Infection ◽  
Simian Immunodeficiency Virus ◽  
Cd8 T Cells ◽  
Simian Immunodeficiency Virus Infection ◽  
Central Nervous System Dysfunction ◽  
Immunodeficiency Virus ◽  
The Brain

scholarly journals Intrathecal Humoral Responses Are Inversely Associated with the Frequency of Simian Immunodeficiency Virus Macrophage-Tropic Variants in the Central Nervous System

2009 ◽  
Vol 83 (16) ◽  
pp. 8282-8288 ◽  
Author(s):  
Elena Ryzhova ◽  
Pyone Aye ◽  
Tom Harvey ◽  
Wei Cao ◽  
Andrew Lackner ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Simian Immunodeficiency Virus ◽  
Humoral Response ◽  
Temporal Course ◽  
Immunodeficiency Virus ◽  
Siv Infection ◽  
The Central Nervous System ◽  
Humoral Responses

ABSTRACT Sustained simian immunodeficiency virus (SIV) infection of the central nervous system (CNS) depends on macrophage-tropic (M-tropic) strains that are often easily neutralizable. The CNS is often thought of as an immunologically privileged site that fosters replication of M-tropic quasispecies. Yet, there are limited data addressing the intrathecal antibody response or the role of the humoral response, in general, to control M-tropic strains. We investigated the temporal course of the intrathecal fusion inhibitory activity against an M-tropic viral variant and found an inverse relationship between the magnitude of this neutralization and the prevalence of M-tropic populations. These studies suggest a role for the humoral response in the suppression of M-tropic viral species in the CNS in experimental SIV infection.

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