scholarly journals Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation

2003 ◽  
Vol 171 (7) ◽  
pp. 3542-3549 ◽  
Author(s):  
Mark S. Sundrud ◽  
Stacy M. Grill ◽  
Donghui Ni ◽  
Kinya Nagata ◽  
Sefik S. Alkan ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
Functional Plasticity ◽  
Th Cell ◽  
Human T Cells

Surface markers of cloned human T cells with helper or suppressor activity on pokeweed mitogen-driven B cell differentiation

1982 ◽  
Vol 12 (10) ◽  
pp. 900-903 ◽  
Author(s):  
Maria Cristina Mingari ◽  
Giovanni Melioli ◽  
Alessandro Moretta ◽  
Giuseppe Pantaleo ◽  
Lorenzo Moretta
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
B Cell ◽  
Pokeweed Mitogen ◽  
Surface Markers ◽  
B Cell Differentiation ◽  
Suppressor Activity ◽  
Human T Cells

scholarly journals Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7

2020 ◽  
Author(s):  
Emilie Coppin ◽  
Bala Sai Sundarasetty ◽  
Susann Rahmig ◽  
Jonas Blume ◽  
Nikita A. Verheyden ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
T Cell ◽  
Regulatory Elements ◽  
T Cell Differentiation ◽  
Human Immune System ◽  
Specific Expression ◽  
Hematopoietic Stem ◽  
Human T Cell ◽  
Human T Cells

AbstractHumanized mouse models have become increasingly valuable tools to study human hematopoiesis and infectious diseases. However, human T cell differentiation remains inefficient. We generated mice expressing human interleukin (IL-7), a critical growth and survival factor for T cells, under the control of murine IL-7 regulatory elements. After transfer of human cord blood-derived hematopoietic stem and progenitor cells, transgenic mice on the NSGW41 background, termed NSGW41hIL7, showed elevated and prolonged human cellularity in the thymus while maintaining physiological ratios of thymocyte subsets. As a consequence, numbers of functional human T cells in the periphery were increased without evidence for pathological lymphoproliferation or aberrant expansion of effector or memory-like T cells. We conclude that the novel NSGW41hIL7 strain represents an optimized mouse model for humanization to better understand human T cell differentiation in vivo and to generate a human immune system with a better approximation of human lymphocyte ratios.

scholarly journals Notch signaling is an important regulator of type 2 immunity

2005 ◽  
Vol 202 (8) ◽  
pp. 1037-1042 ◽  
Author(s):  
LiLi Tu ◽  
Terry C. Fang ◽  
David Artis ◽  
Olga Shestova ◽  
Seth E. Pross ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
Notch Signaling ◽  
Leishmania Major ◽  
Th2 Cells ◽  
Th1 Cell ◽  
Trichuris Muris ◽  
Type 2 Immunity ◽  
Th Cell

Notch ligands and receptors have been implicated in helper T cell (Th cell) differentiation. Whether Notch signals are involved in differentiation of T helper type 1 (Th1) cells, Th2 cells, or both, however, remains unresolved. To clarify the role of Notch in Th cell differentiation, we generated mice that conditionally inactivate Notch signaling in mature T cells. Mice that lack Notch signaling in CD4+ T cells fail to develop a protective Th2 cell response against the gastrointestinal helminth Trichuris muris. In contrast, they exhibit effective Th1 cell responses and are able to control Leishmania major infection. These data demonstrate that Notch signaling is a regulator of type 2 immunity.

scholarly journals Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells

2006 ◽  
Vol 18 (12) ◽  
pp. 1681-1690 ◽  
Author(s):  
J. Yagi ◽  
Y. Arimura ◽  
H. Takatori ◽  
H. Nakajima ◽  
I. Iwamoto ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
Cd4 T Cells ◽  
Genetic Background ◽  
Th Cell

scholarly journals Arthritogenic SKG T cells are il-2 deficient and demonstrate distinct patterns of Th cell differentiation; reversal of the th17 phenotype by il-2

2011 ◽  
Vol 70 (Suppl 2) ◽  
pp. A49-A49
Author(s):  
O. Smonezi ◽  
A. Annenkov ◽  
T. Tharmalingam ◽  
Y. Chernajowsky ◽  
R. Williams ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
Th Cell

scholarly journals Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility

2014 ◽  
Vol 15 (8) ◽  
pp. 777-788 ◽  
Author(s):  
Grégory Seumois ◽  
Lukas Chavez ◽  
Anna Gerasimova ◽  
Matthias Lienhard ◽  
Nada Omran ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
Memory Cell ◽  
Asthma Susceptibility ◽  
Human T Cells

scholarly journals The Role of Protein Modifications of T-Bet in Cytokine Production and Differentiation of T Helper Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Sera Oh ◽  
Eun Sook Hwang
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
Cytokine Production ◽  
Multiple Roles ◽  
Lymphoid Cells ◽  
T Helper ◽  
Independent Manner ◽  
Protein Modifications ◽  
Th Cell ◽  
Nk T Cells

T-Bet (T-box protein expressed in T cells, also called as TBX21) was originally cloned as a key transcription factor involved in the commitment of T helper (Th) cells to the Th1 lineage. T-Bet directly activates IFN-γgene transcription and enhances development of Th1 cells. T-Bet simultaneously modulates IL-2 and Th2 cytokines in an IFN-γ-independent manner, resulting in an attenuation of Th2 cell development. Numerous studies have demonstrated that T-bet plays multiple roles in many subtypes of immune cells, including B cell, dendritic cells, natural killer (NK) cells, NK T cells, and innate lymphoid cells. Therefore, T-bet is crucial for the development and coordination of both innate and adaptive immune responses. To fulfill these multiple roles, T-bet undergoes several posttranslational protein modifications, such as phosphorylation at tyrosine, serine, and threonine residues, and ubiquitination at lysine residues, which affect lineage commitment during Th cell differentiation. This review presents a current overview of the progress made in understanding the roles of various types of T-bet protein modifications in the regulation of cytokine production during Th cell differentiation.

Sign in / Sign up

Export Citation Format

Share Document