scholarly journals Influenza Virus Infection Causes Global Respiratory Tract B Cell Response Modulation via Innate Immune Signals

2007 ◽  
Vol 178 (3) ◽  
pp. 1457-1467 ◽  
Author(s):  
W. L. William Chang ◽  
Elizabeth S. Coro ◽  
Friederike C. Rau ◽  
Yuanyuan Xiao ◽  
David J. Erle ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Respiratory Tract ◽  
B Cell ◽  
Cell Response ◽  
Influenza Virus Infection ◽  
Innate Immune ◽  
Response Modulation ◽  
B Cell Response

scholarly journals CD4 T Cell Help Is Limiting and Selective during the Primary B Cell Response to Influenza Virus Infection

2013 ◽  
Vol 88 (1) ◽  
pp. 314-324 ◽  
Author(s):  
S. Alam ◽  
Z. A. G. Knowlden ◽  
M. Y. Sangster ◽  
A. J. Sant
Keyword(s):  
Influenza Virus ◽  
T Cell ◽  
Virus Infection ◽  
B Cell ◽  
Cell Response ◽  
Influenza Virus Infection ◽  
Cd4 T Cell ◽  
Cd4 T Cell Help ◽  
T Cell Help ◽  
B Cell Response

Role of the B-cell response in recovery of mice from primary influenza virus infection

1997 ◽  
Vol 159 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Walter Gerhard ◽  
Krystyna Mozdzanowska ◽  
Michelle Furchner ◽  
George Washko ◽  
Krista Maiese
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
B Cell ◽  
Cell Response ◽  
Influenza Virus Infection ◽  
B Cell Response

scholarly journals A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection

2011 ◽  
Vol 8 (6) ◽  
pp. 462-468 ◽  
Author(s):  
Xiaohui Wang ◽  
Chris CS Chan ◽  
Min Yang ◽  
Jun Deng ◽  
Vincent KM Poon ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
B Cell ◽  
Cell Response ◽  
Critical Role ◽  
Influenza Virus Infection ◽  
H5n1 Influenza Virus ◽  
H5n1 Influenza ◽  
B Cell Response

scholarly journals Lethal Coinfection of Influenza Virus and Streptococcus pneumoniae Lowers Antibody Response to Influenza Virus in Lung and Reduces Numbers of Germinal Center B Cells, T Follicular Helper Cells, and Plasma Cells in Mediastinal Lymph Node

2014 ◽  
Vol 89 (4) ◽  
pp. 2013-2023 ◽  
Author(s):  
Yuet Wu ◽  
Wenwei Tu ◽  
Kwok-Tai Lam ◽  
Kin-Hung Chow ◽  
Pak-Leung Ho ◽  
...  
Keyword(s):  
Influenza Virus ◽  
B Cells ◽  
Virus Infection ◽  
B Cell ◽  
Cell Response ◽  
Plasma Cells ◽  
Pneumococcal Infection ◽  
Influenza Virus Infection ◽  
Follicular Helper ◽  
B Cell Response

ABSTRACTSecondaryStreptococcus pneumoniaeinfection after influenza is a significant clinical complication resulting in morbidity and sometimes mortality. Prior influenza virus infection has been demonstrated to impair the macrophage and neutrophil response to the subsequent pneumococcal infection. In contrast, how a secondary pneumococcal infection after influenza can affect the adaptive immune response to the initial influenza virus infection is less well understood. Therefore, this study focuses on how secondary pneumococcal infection after influenza may impact the humoral immune response to the initial influenza virus infection in a lethal coinfection mouse model. Compared to mice infected with influenza virus alone, mice coinfected with influenza virus followed by pneumococcus had significant body weight loss and 100% mortality. In the lung, lethal coinfection significantly increased virus titers and bacterial cell counts and decreased the level of virus-specific IgG, IgM, and IgA, as well as the number of B cells, CD4 T cells, and plasma cells. Lethal coinfection significantly reduced the size and weight of spleen, as well as the number of B cells along the follicular developmental lineage. In mediastinal lymph nodes, lethal coinfection significantly decreased germinal center B cells, T follicular helper cells, and plasma cells. Adoptive transfer of influenza virus-specific immune serum to coinfected mice improved survival, suggesting the protective functions of anti-influenza virus antibodies. In conclusion, coinfection reduced the B cell response to influenza virus. This study helps us to understand the modulation of the B cell response to influenza virus during a lethal coinfection.IMPORTANCESecondary pneumococcal infection after influenza virus infection is an important clinical issue that often results in excess mortality. Since antibodies are key mediators of protection, this study aims to examine the antibody response to influenza virus and demonstrates that lethal coinfection reduced the B cell response to influenza virus. This study helps to highlight the complexity of the modulation of the B cell response in the context of coinfection.

scholarly journals Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

2011 ◽  
Vol 208 (2) ◽  
pp. 411-411 ◽  
Author(s):  
Jens Wrammert ◽  
Dimitrios Koutsonanos ◽  
Gui-Mei Li ◽  
Srilatha Edupuganti ◽  
Jianhua Sui ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
B Cell ◽  
Cell Response ◽  
Influenza Virus Infection ◽  
H1n1 Influenza ◽  
Pandemic H1n1 ◽  
H1n1 Influenza Virus ◽  
Pandemic H1n1 Influenza ◽  
Human B Cell
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