scholarly journals Regulation of αβ/γδ T Cell Development by the Activator Protein 1 Transcription Factor c-Jun

2007 ◽  
Vol 178 (9) ◽  
pp. 5690-5700 ◽  
Author(s):  
Lluís Riera-Sans ◽  
Axel Behrens
Keyword(s):  
Transcription Factor ◽  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Activator Protein 1 ◽  
Γδ T Cell ◽  
Activator Protein ◽  
Factor C

scholarly journals CD45 Molecule in γδ T-Cell Generation: Disruption of CD45 Exon 6 Does Not Affect Vγ3 Dendritic Epidermal T-Cell Development

1997 ◽  
Vol 108 (1) ◽  
pp. 49-52 ◽  
Author(s):  
Binghe Wang ◽  
Hiroshi Fujisawa ◽  
Seiji Kondo ◽  
Gulnar G. Shivji ◽  
Danel N. Sauder
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Cell Generation ◽  
Γδ T Cell

scholarly journals CCR7-mediated migration in the thymus controls γδ T-cell development

2014 ◽  
Vol 44 (5) ◽  
pp. 1320-1329 ◽  
Author(s):  
Annika Reinhardt ◽  
Sarina Ravens ◽  
Henrike Fleige ◽  
Jan D. Haas ◽  
Linda Oberdörfer ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Γδ T Cell

Role of Itk in γδ T cell development and function

2008 ◽  
Vol 22 (S2) ◽  
pp. 410-410
Author(s):  
Catherine Chih‐tzu Yin ◽  
Martin Felices ◽  
Yoko Kosaka ◽  
Joonsoo Kang
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Γδ T Cell ◽  
And Function

scholarly journals Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas

2015 ◽  
Vol 112 (25) ◽  
pp. 7773-7778 ◽  
Author(s):  
Hyung-Ok Lee ◽  
Xiao He ◽  
Jayati Mookerjee-Basu ◽  
Dai Zhongping ◽  
Xiang Hua ◽  
...  
Keyword(s):  
Transcription Factor ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
T Cell Development ◽  
Cell Receptor ◽  
Cell Development ◽  
Thymocyte Development ◽  
Tcr Signaling ◽  
Double Positive ◽  
Human T Cell

The transcription factor T-helper-inducing POZ/Krueppel-like factor (ThPOK, encoded by the Zbtb7b gene) plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. Here we show that mice expressing a constitutive T-cell–specific ThPOK transgene (ThPOKconst mice) develop thymic lymphomas. These tumors resemble human T-cell acute lymphoblastic leukemia (T-ALL), in that they predominantly exhibit activating Notch1 mutations. Lymphomagenesis is prevented if thymocyte development is arrested at the DN3 stage by recombination-activating gene (RAG) deficiency, but restored by introduction of a T-cell receptor (TCR) transgene or by a single injection of anti-αβTCR antibody into ThPOKconst RAG-deficient mice, which promotes development to the CD4+8+ (DP) stage. Hence, TCR signals and/or traversal of the DN (double negative) > DP (double positive) checkpoint are required for ThPOK-mediated lymphomagenesis. These results demonstrate a novel link between ThPOK, TCR signaling, and lymphomagenesis. Finally, we present evidence that ectopic ThPOK expression gives rise to a preleukemic and self-perpetuating DN4 lymphoma precursor population. Our results collectively define a novel role for ThPOK as an oncogene and precisely map the stage in thymopoiesis susceptible to ThPOK-dependent tumor initiation.

scholarly journals Disruption of αβ but not of γδ T cell development by overexpression of the helix–loop–helix protein Id3 in committed T cell progenitors

1999 ◽  
Vol 18 (10) ◽  
pp. 2793-2802 ◽  
Author(s):  
Bianca Blom ◽  
Mirjam H.M. Heemskerk ◽  
Martie C.M. Verschuren ◽  
Jacques J.M. van Dongen ◽  
Alexander P.A. Stegmann ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Γδ T Cell ◽  
Helix Loop Helix ◽  
T Cell Progenitors

scholarly journals IκBNS Protein Mediates Regulatory T Cell Development via Induction of the Foxp3 Transcription Factor

Immunity ◽  
2012 ◽  
Vol 37 (6) ◽  
pp. 998-1008 ◽  
Author(s):  
Marc Schuster ◽  
Rainer Glauben ◽  
Carlos Plaza-Sirvent ◽  
Lisa Schreiber ◽  
Michaela Annemann ◽  
...  
Keyword(s):  
Transcription Factor ◽  
T Cell ◽  
Regulatory T Cell ◽  
T Cell Development ◽  
Cell Development

A retrospective on the requirements for γδ T-cell development

2007 ◽  
Vol 215 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Sandra M. Hayes ◽  
Paul E. Love
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Γδ T Cell

scholarly journals Deciphering the regulatory landscape of fetal and adult γδ T‐cell development at single‐cell resolution

2020 ◽  
Vol 39 (13) ◽  
Author(s):  
Sagar ◽  
Maria Pokrovskii ◽  
Josip S Herman ◽  
Shruti Naik ◽  
Elisabeth Sock ◽  
...  
Keyword(s):  
T Cell ◽  
Single Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Γδ T Cell ◽  
Regulatory Landscape

Separate Ways

2007 ◽  
Vol 2007 (369) ◽  
pp. tw23-tw23
Author(s):  
Stephen Simpson
Keyword(s):  
T Cells ◽  
Transcription Factor ◽  
T Cell ◽  
Cell Fate ◽  
T Cell Development ◽  
Γδ T Cells ◽  
Anatomical Location ◽  
Γδ T Cell ◽  
Link Type ◽  
Common Precursor

Two dominant lineages of T cells (αβ and γδ T cells) are highly distinct in function and anatomical location yet share a common precursor within the thymus. Exactly how one cell fate is decided over another remains unresolved. Melichar et al. present evidence that selection to the γδ T cell branch in the thymus is controlled by the transcription factor SOX13, which supports and possibly even initiates γδ T cell development while opposing differentiation of their αβ T cell brethren. The authors noted that SOX13 inhibited an important effector of the central T cell developmental signaling pathway mediated by the Wnt protein. H. J. Melichar, K. Narayan, S. D. Der, Y. Hiraoka, N. Gardiol, G. Jeannet, W. Held, C. A. Chambers, J. Kang, Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13. Science315, 230-233 (2007). [Abstract][Full Text]

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