scholarly journals Cutting Edge: Inhibition of Glycogen Synthase Kinase 3 Activity Induces the Generation and Enhanced Suppressive Function of Human IL-10+ FOXP3+–Induced Regulatory T Cells

2020 ◽  
Vol 205 (6) ◽  
pp. 1497-1502
Author(s):  
Hao Cheng ◽  
Lingbiao Wang ◽  
Biaolong Yang ◽  
Dan Li ◽  
Xiaoxia Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Glycogen Synthase ◽  
Cutting Edge ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Suppressive Function

scholarly journals Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells

1999 ◽  
Vol 11 (3) ◽  
pp. 317-323 ◽  
Author(s):  
Frank J. T. Staal ◽  
Boudewijn M. T. Burgering ◽  
Marc van de Wetering ◽  
Hans C. Clevers
Keyword(s):  
T Cells ◽  
T Lymphocytes ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3

scholarly journals Lithium regulates keratinocyte proliferation via glycogen synthase kinase 3 and NFAT2 (nuclear factor of activated T cells 2)

2012 ◽  
Vol 227 (4) ◽  
pp. 1529-1537 ◽  
Author(s):  
Philip J. Hampton ◽  
Ralph Jans ◽  
Ross J. Flockhart ◽  
Graeme Parker ◽  
Nick J. Reynolds
Keyword(s):  
T Cells ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Nuclear Factor ◽  
Activated T Cells ◽  
Keratinocyte Proliferation

scholarly journals Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells

2019 ◽  
Author(s):  
Alison Taylor ◽  
Christopher E. Rudd
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Motility ◽  
Glycogen Synthase ◽  
Antigen Presenting Cells ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Serine Kinase ◽  
Multiple Substrates ◽  
Antigen Presenting

Abstract Objective: The threonine/serine kinase glycogen synthase kinase 3 (GSK-3) targets multiple substrates in T-cells, regulating the expression of Tbet and PD-1 on T-cells. However, it has been unclear whether GSK-3 can affect the motility of T-cells and their interactions with antigen presenting cells. Results: Here, we show that GSK-3 can regulate T-cell motility. Inhibition of GSK-3, by small molecule SB415286, reduced T-cell motility in terms of distance and displacement. Although SB415286 reduced the number of contacts, the dwell times of established contacts did not differ between T-cells treated with SB415286. These data indicate show that the inhibition of GSK-3 can influence the motility of T-cells and interactions with other cells without affecting the dwell times of cells that make productive contacts.

scholarly journals Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells

2019 ◽  
Author(s):  
Alison Taylor ◽  
Christopher E. Rudd
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Motility ◽  
Glycogen Synthase ◽  
Antigen Presenting Cells ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Serine Kinase ◽  
Multiple Substrates ◽  
Antigen Presenting

Abstract Objective: The threonine/serine kinase glycogen synthase kinase 3 (GSK-3) targets multiple substrates in T-cells, regulating the expression of Tbet and PD-1 on T-cells. However, it has been unclear whether GSK-3 can affect the motility of T-cells and their interactions with antigen presenting cells. Results: Here, we show that GSK-3 can regulate T-cell motility. Inhibition of GSK-3, by small molecule SB415286, reduced T-cell motility in terms of distance and displacement. Although SB415286 reduced the number of contacts, the dwell times of established contacts did not differ between T-cells treated with SB415286. These data indicate show that the inhibition of GSK-3 can influence the motility of T-cells and interactions with other cells without affecting the dwell times of cells that make productive contacts.

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