IL-33 Coordinates Innate Defense to Systemic Candida albicans Infection by Regulating IL-23 and IL-10 in an Opposite Way

2022 ◽  
pp. ji2100495
Author(s):  
Nu Z. N. Nguyen ◽  
Vuvi G. Tran ◽  
Jiyeon Baek ◽  
Younghee Kim ◽  
Eun H. Youn ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Innate Defense ◽  
Candida Albicans Infection

scholarly journals CD137 Signaling Is Critical in Fungal Clearance during Systemic Candida albicans Infection

2021 ◽  
Vol 7 (5) ◽  
pp. 382
Author(s):  
Vuvi G. Tran ◽  
Na N. Z. Nguyen ◽  
Byungsuk Kwon
Keyword(s):  
Candida Albicans ◽  
Defense Mechanisms ◽  
Tumor Necrosis ◽  
Fungal Infections ◽  
Fungal Growth ◽  
Wild Type ◽  
Agonistic Antibody ◽  
Innate Defense ◽  
Surface Receptor ◽  
Candida Albicans Infection

Invasive fungal infections by Candida albicans frequently cause mortality in immunocompromised patients. Neutrophils are particularly important for fungal clearance during systemic C. albican infection, yet little has been known regarding which surface receptor controls neutrophils’ antifungal activities. CD137, which is encoded by Tnfrsf9, belongs to the tumor necrosis receptor superfamily and has been shown to regulate neutrophils in Gram-positive bacterial infection. Here, we used genetic and immunological tools to probe the involvement of neutrophil CD137 signaling in innate defense mechanisms against systemic C. albicans infection. We first found that Tnfrsf9−/− mice were susceptible to C. albicans infection, whereas injection of anti-CD137 agonistic antibody protected the host from infection, suggesting that CD137 signaling is indispensable for innate immunity against C. albicans infection. Priming of isolated neutrophils with anti-CD137 antibody promoted their phagocytic and fungicidal activities through phospholipase C. In addition, injection of anti-CD137 antibody significantly augmented restriction of fungal growth in Tnfrsf9−/− mice that received wild-type (WT) neutrophils. In conclusion, our results demonstrate that CD137 signaling contributes to defense mechanisms against systemic C. albicans infection by promoting rapid fungal clearance.

THE INFLUENCE OF WHOLE SONICATE BRUCELLA ABORTUS ANTIGEN ON THE CANDIDA ALBICANS INFECTION IN MICE

2009 ◽  
Vol 8 (1) ◽  
pp. 48-59
Author(s):  
A M.J ◽  
A S.S ◽  
A I.A ◽  
A Al-Oubaidy ◽  
A Alwan ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Brucella Abortus ◽  
Candida Albicans Infection

Suppression of humoral response during the course of Candida albicans infection in mice

1984 ◽  
Vol 88 (1) ◽  
pp. 61-63 ◽  
Author(s):  
Juan Carlos Valdez ◽  
Oscar Enrique Meson ◽  
Graciela Aciar de Valdez ◽  
Angel Sirena
Keyword(s):  
Candida Albicans ◽  
Humoral Response ◽  
Candida Albicans Infection

Elimination of Candida albicans Infection of the Radicular Dentin by Intracanal Medications

2003 ◽  
Vol 29 (8) ◽  
pp. 501-504 ◽  
Author(s):  
J SIQUEIRAJR ◽  
I ROCAS ◽  
H LOPES ◽  
F MAGALHAES ◽  
M DEUZEDA
Keyword(s):  
Candida Albicans ◽  
Candida Albicans Infection

Efficacy of the Combined Treatment with Fluconazole and Thymosin α 1 Against Candida albicans Infection in Morphine-Treated Mice

1993 ◽  
pp. 189-194
Author(s):  
Paolo Di Francesco ◽  
Roberta Gaziano ◽  
Francesca Pica ◽  
Ida Casalinuovo ◽  
Anna Teresa Palamara ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Combined Treatment ◽  
Candida Albicans Infection

scholarly journals Protective effect of a muramyl dipeptide analog encapsulated in or mixed with liposomes against Candida albicans infection.

1983 ◽  
Vol 39 (1) ◽  
pp. 172-178 ◽  
Author(s):  
E B Fraser-Smith ◽  
D A Eppstein ◽  
M A Larsen ◽  
T R Matthews
Keyword(s):  
Candida Albicans ◽  
Protective Effect ◽  
Muramyl Dipeptide ◽  
Candida Albicans Infection

scholarly journals CD137 Signaling is Critical in Fungal Clearance During Systemic Candida albicans Infection

2021 ◽  
Author(s):  
Vu Vi Giang Tran ◽  
Zen Na Nu Nguyen ◽  
Byungsuk Kwon
Keyword(s):  
Innate Immunity ◽  
Candida Albicans ◽  
Defense Mechanisms ◽  
Tumor Necrosis ◽  
Fungal Infections ◽  
Fungal Growth ◽  
Immunocompromised Patients ◽  
Agonistic Antibody ◽  
Innate Defense ◽  
Surface Receptor

Invasive fungal infections by Candida albicans frequently cause mortality in immunocompromised patients. Neutrophils are particularly important for fungal clearance at the early phase of infections, yet little has been known regarding which surface receptor controls neutrophil phagocytic activities during systemic C. albicans infection. CD137, which is encoded by Tnfrsf9, belongs to the tumor necrosis receptor superfamily and has been shown to regulate neutrophils in Gram-positive bacterial infection. Here, we used genetic and immunological tools to probe the involvement of CD137 signaling in innate defense mechanisms against systemic C. albicans infection. We first found that Tnfrsf9-/- mice were susceptible to C. albicans infection, whereas injection of anti-CD137 agonistic antibody protected the host from infection, suggesting that CD137 signaling is indispensable for innate immunity against C. albicans infection. Priming of isolated neutrophils with anti-CD137 antibody promoted their phagocytic and fungicidal activities through phospholipase C. In addition, injection of anti-CD137 antibody significantly augmented restriction of fungal growth in Tnfrsf9-/- mice that received WT neutrophils. In conclusion, our results demonstrate that CD137 signaling contributes to defense mechanisms against systemic C. albicans infection by promoting rapid fungal clearance whereby harmful immunopathology-induced tissue injuries are minimalized.

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