scholarly journals Sudden sensorineural hearing loss: What factors influence the response to therapy?

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Pasqua Irene Sciancalepore ◽  
Valentina De Robertis ◽  
Rodolfo Sardone ◽  
Nicola Quaranta
Keyword(s):  
Hearing Loss ◽  
Prognostic Factors ◽  
Sensorineural Hearing Loss ◽  
Oral Treatment ◽  
Microvascular Dysfunction ◽  
Sudden Sensorineural Hearing Loss ◽  
Steroid Treatment ◽  
Response To Therapy ◽  
Sensorineural Hearing ◽  
Delayed Treatment

The standard treatment of Sudden Sensorineural Hearing Loss is based on oral steroids. In addition, intratympanic steroid is currently used in patients who fail to respond to oral treatment. The aim of the present study was to evaluate, in patients affected by SSHL, factors that influence the response to systemic and intratympanic steroid treatment. A retrospective analysis was conducted on 149 patients, all treated with systemic steroids. Moreover, patients not responsive to systemic therapy were treated with intratympanic steroids as salvage therapy. Auditory gain was assessed through the recovery rate at the discharge and after 30 days. Statistical analysis demonstrated that patients with delayed treatment and down-sloping auditory curve presented a poor recovery. Linear and stepwise regression showed that hypertriglyceridemia and hyperglycemia were negative prognostic factors. The prognosis of SSHL is affected by hyperglycemia and hypertriglyceridemia suggesting that a microvascular dysfunction within the cochlea could impair hearing recovery. Intratympanic steroid treatment was used as salvage treatment, however in patients with poor prognostic factors or at risk for side effects, it could be used in association with systemic treatment.

Intratympanic injection with dexamethasone for sudden sensorineural hearing loss

2010 ◽  
Vol 125 (2) ◽  
pp. 133-137 ◽  
Author(s):  
Y-J Tsai ◽  
J-G Liang ◽  
W-B Wu ◽  
Y-F Ding ◽  
R P-Y Chiang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Steroid Therapy ◽  
Response Rate ◽  
Steroid Injection ◽  
Disease Onset ◽  
Sudden Sensorineural Hearing Loss ◽  
Steroid Treatment ◽  
Sensorineural Hearing ◽  
Delayed Treatment

AbstractObjective:To investigate the efficacy of intratympanic steroid therapy in adults with sudden sensorineural hearing loss, and to analyse the factors associated with treatment outcome.Design:Retrospective study of patients undergoing intratympanic steroid injection for sudden sensorineural hearing loss between 1 January 2006 and 30 June 2007 at a teaching hospital in Taipei, Taiwan.Results:Patients who received intratympanic steroid therapy within seven days of disease onset achieved a significantly better response rate (76.1 per cent), compared with the delayed treatment group (50 per cent). The total response rate, after four steroid injections, was 68.9 per cent. Patients with low and mid-frequency hearing loss were more responsive to steroid treatment. Vertigo was a negative prognostic factor for recovery. There were no long-term sequelae of intratympanic steroid treatment.Conclusion:Intratympanic steroid injection may be a simple and effective treatment for patients with sudden sensorineural hearing loss.

Multivariate analysis of prognostic factors for idiopathic sudden sensorineural hearing loss in children

2015 ◽  
Vol 125 (9) ◽  
pp. 2209-2215 ◽  
Author(s):  
Jae Ho Chung ◽  
Seok Hyun Cho ◽  
Jin Hyeok Jeong ◽  
Chul Won Park ◽  
Seung Hwan Lee
Keyword(s):  
Hearing Loss ◽  
Multivariate Analysis ◽  
Prognostic Factors ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing

Sudden Sensorineural Hearing Loss: Prognostic Factors

2004 ◽  
Vol 131 (2) ◽  
pp. P49-P49
Author(s):  
John Xenellis ◽  
Ioannis G Karapatsas ◽  
Nikolaos Papadimitriou ◽  
Thomas Nikolopoulos ◽  
Paulos Maragoudakis ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Prognostic Factors ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing

scholarly journals “Clinical Profile & Prognostic Factors In Patients with Sudden Sensorineural Hearing Loss”

2021 ◽  
Vol 8 (12) ◽  
pp. 5830-5835
Author(s):  
Md. Feroz Hossen ◽  
Mahbubul Alam Choudhury
Keyword(s):  
Hearing Loss ◽  
Prognostic Factors ◽  
Sensorineural Hearing Loss ◽  
Pure Tone ◽  
Winter Season ◽  
Hearing Threshold ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Clinical Profile ◽  
Pure Tone Audiogram

Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is an emergency disease requiring immediate diagnosis and treatment. The incidence of ISSNHL in the Western countries’ population was estimated to 5–20 per 100,000 inhabitants. The etiology of ISSNHL remains unknown. Its pathogenesis is most often suggested to be due to a disturbed microcirculation and infection. Objective: To study the clinical profile & prognostic factors in patients with sudden sensorineural hearing loss. Material and Methods: A retrospective study was carried out from patients of sudden sensineural hearing loss (SSNHL) presenting to ENT Department ofNorthern Private Medical College, Rangpur, Bangladesh from January to June-2020. All patients were given intravenous steroids as treatment modality for 14 days and pure tone audiogram was done every 3 days during hospital admission. It was followed by oral steroids in tapering dose for further 14 days. After 1 month, audiogram was done again. After 1 month if hearing threshold was decreased by more than 50% of presenting one, then it was labeled as improved. Results:Total 51 patients (55ears) with age ranging from 6-70 years (average-38.5 years) were included. Three fourth were male. Presentation was 1-14days after onset of hearing loss (average- 3.7days) with pure tone audiogram (PTA) of 38-117dB (average 83.1dB). The flat audiogram (62.3%) was most common type. Smoking was present in 14 patients and tinnitus in 30 ears. Hemoglobin ranged from 7.3-18.7gm %( average- 15.3gm/dl). PTA post treatment was 8-73dB (average- 56dB). Average age of improved patient was 39.8years which was lower than non-improved patients (42.3years). In improved patients, average PTA at presentation was 77.9dB while it was 86.6dB in non-improved patients. Conclusion: Our study demonstrates that the age distribution and clinical characteristics of ISSNHL patients vary according to levels of hearing loss. Moreover, ISSNHL patients with vertigo tend to sufer from a more severe hearing loss. Further studies are needed to obtain better knowledge about the etiopathogenesis of SSNHL.  SSNHL is more commonly seen in male patients with polycythaemia and is commonly presented in winter season and is frequently associated with tinnitus. Young age and lower audiogram threshold at presentation favor prognosis.

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