scholarly journals Erythroplasia of Queyrat

2012 ◽  
Vol 2 (3) ◽  
pp. 63 ◽  
Author(s):  
Deirdre Mary Fanning ◽  
Hugh Flood
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
Cell Cancer ◽  
Skin Grafting ◽  
Invasive Squamous Cell Carcinoma ◽  
Erythroplasia Of Queyrat ◽  
Penile Squamous Cell Carcinoma

A 58-year-old Caucasian male presented to the urology clinic reporting an approximate one-year history of a persistent irritating, slowly progressive, glans penis redness. Biopsy revealed penile squamous cell carcinoma <em>in situ</em>. He underwent a partial glansectomy with circumcision and skin grafting. At three months follow-up there is no evidence of local disease recurrence. In western countries, primary malignant penile cancer is uncommon, with an incidence of less than 1 per 100,000 males. Squamous cell cancer accounts for more than 95% of cases of penile cancer. Squamous cell carcinoma <em>in situ</em> on the penile mucosa or transitional surfaces is also known as Erythroplasia of Queyrat. In the region, one third of penile squamous cell carcinoma <em>in situ </em>cases progress to invasive squamous cell carcinoma.

scholarly journals Penile squamous cell carcinoma :a three-year study at BP Koirala Memorial Cancer Hospital

2019 ◽  
Vol 2 (3) ◽  
pp. 149-153
Author(s):  
Shankar Bastakoti ◽  
Ranjan Raj Bhatta ◽  
Nandita Jha ◽  
Sadina Shrestha ◽  
Amrita Paudel
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
The Elderly ◽  
Prognostic Indicator ◽  
Study Data ◽  
Cancer Hospital ◽  
Well Differentiated ◽  
Penile Squamous Cell Carcinoma

Background: Penile cancer is an aggressive and mutilating disease which deeply affects self-esteem and daily life of the patient. Penile cancer mostly affects the elderly, seen in people in their sixties and seventies. Occurrence in younger age is a need of research of penile neoplasia in young non-circumcised patients. Materials and Method: This is a three-year retrospective study. Data was extracted from the Department of Pathology and Medical Record section of B.P. Koirala Memorial Cancer Hospital. All histologically proven cases were included. The objective of this study was to assess clinical histopathological profile of penile carcinoma. Results. A total of 114 malignant cases were included out of which most common age group involved was 50-60 years with mean age of presentation being 51.6 years. Glans was the commonest site of involvement in 59 cases (51.7%). Well-differentiated squamous cell carcinoma was the most common type (71%). Forty nine patients (43%) presented when the mass size was 4-6 cm and 44 (39%) came with 2-4cm and rest less than 2 cm. Lymphvascular invasion was seen in 15 (13%) out of 114 cases and perineural invasion was seen only in 5 (4.3%) cases. 20 cases (17.5%) had lymphnodes positive which are less than 5 lymphnode positive and five (4.3%) had more than 5 lymphnodes positive. Conclusion. Early diagnosis and intervention of the patient ensure high probability of getting cured because the stage at presentation appears to be the most vital prognostic indicator for survival.  

Metastatic penile squamous cell carcinoma with dramatic response to combined checkpoint blockade with ipilimumab and nivolumab

2020 ◽  
pp. 107815522092260
Author(s):  
Abinav Baweja ◽  
Nataliya Mar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
Checkpoint Inhibitors ◽  
Papilloma Virus ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Penile Squamous Cell Carcinoma

Introduction Prognosis for patients with lymph node positive or metastatic penile squamous cell carcinoma remains poor. Chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP regimen) is recommended as a first-line option in this cohort of patients. No standard preferred subsequent-line therapy exists for patients with relapsed or refractory penile carcinoma following TIP chemotherapy. Molecular pathogenesis of penile cancer can be subdivided into human papilloma virus-dependent and human papilloma virus-independent pathways. Recent studies have demonstrated increased expression of programmed death ligand-1 in some penile tumors, commonly those that are human papilloma virus-negative. Given the rarity of penile carcinoma in industrialized countries and lack of effective therapies, checkpoint inhibitors may be an attractive treatment option for this subset of patients. Case report We report a case of metastatic penile cancer refractory to TIP chemotherapy, with a dramatic treatment response to ipilimumab and nivolumab. Molecular profiling of this tumor showed a high programmed death ligand-1 expression, high tumor mutational burden, high microsatellite instability, and alterations in DNA mismatch repair genes. Discussion This case highlights another dimension of information that may be gained with molecular genomic profiling of penile tumors, providing insight into the biologic behavior of this neoplasm and assessing for predictive biomarkers of response to immune checkpoint inhibitors.

scholarly journals Imaging for the Initial Staging and Post-Treatment Surveillance of Penile Squamous Cell Carcinoma

Diagnostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 170
Author(s):  
Samuel J. Galgano ◽  
John C. Norton ◽  
Kristin K. Porter ◽  
Janelle T. West ◽  
Soroush Rais-Bahrami
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
The United States ◽  
Positron Emission ◽  
Ultrasound Computed Tomography ◽  
Penile Squamous Cell Carcinoma ◽  
Almost All ◽  
Initial Staging

Although relatively rare in the United States, penile squamous cell carcinoma is encountered worldwide at a higher rate. Initial diagnosis is often made on clinical exam, as almost all of these lesions are externally visible and amenable to biopsy. In distinction to other types of malignancies, penile cancer relies heavily on clinical nodal staging of the inguinal lymph node chains. As with all cancers, imaging plays a role in the initial staging, restaging, and surveillance of these patients. The aim of this manuscript is to highlight the applications, advantages, and limitations of different imaging modalities in the evaluation of penile cancer, including ultrasound, computed tomography, magnetic resonance imaging, and positron emission tomography.

scholarly journals Cutaneous Bowen’s Disease: an Analysis of 182 Cases according To Age, Sex, and Anatomical Site from an Italian Center

2019 ◽  
Vol 7 (4) ◽  
pp. 696-697
Author(s):  
Massimiliano Scalvenzi ◽  
Alessia Villani ◽  
Caterina Mazzella ◽  
Gabriella Fabbrocini ◽  
Claudia Costa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Anatomical Site ◽  
Invasive Squamous Cell Carcinoma ◽  
Bowen’S Disease ◽  
Bowen's Disease ◽  
Exposed Region ◽  
Male Patients

Bowen's disease (BD), also known as squamous cell carcinoma in situ, is a type of non-melanocytic intraepidermal malignancy characterised by a slowly enlarging erythematous to pink, scaly patch or plaque with irregular and well-demarcated borders. These lesions are usually persistent and progressive; it has been estimated that in general population around 3% to 5% of Bowen's disease transform into invasive squamous cell carcinoma. This report describes our experience with cutaneous BD and assesses the differences found about age, sex and anatomical site. Bowen’s disease was seen more frequently in male patients rather than in female patients in contrast to what confirmed in literature - this difference is probably because being head-neck an exposed region, patients are more easily induced to autoexam and to consult the dermatologist.

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