scholarly journals A case report of severe veno-occlusive disease following autologous stem cell transplantation successfully treated with Defibrotide

2020 ◽  
Author(s):  
Gholamreza Bahoush ◽  
Maryam Vafapour
Keyword(s):  
Differential Diagnosis ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Organ Failure ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
High Mortality ◽  
Occlusive Disease ◽  
Multi Organ Failure ◽  
Liver Injuries

Veno-occlusive disease (VOD) is one of the complications of hematopoietic stem cell transplantation that can also be caused by high-dose chemotherapy. This complication can lead to high mortality following bone marrow transplantation. It is more common after allogeneic stem cell transplantation, and is rare after autologous stem cell transplantation. While mild cases of VOD may reduce over a period of a few weeks, very severe cases can cause multi-organ damage, which has a high mortality. is therefore required with early diagnosis and treatment of this complication. In this paper, we present a sever VOD case after autologous stem cell transplantation, that was treated successfully with Defibrotide. The patient was a 14-month-old girl who has neuroblastoma with bone metastasis. VOD should be considered in the differential diagnosis of haematopoietic stem cell transplantation recipients who present with unexplained liver injuries, ascites and/or multi organ failure. Recipients of haematopoeitic stem cell transplantation who present with unexplained liver injuries, ascites and/or multi organ failure should have VOD considered in their differential diagnosis. If there is severe VOD diagnosed, then Defibrotide could be an option for treatment.

scholarly journals A case report of severe veno-occlusive disease following autologous stem cell transplantation successfully treated with Defibrotide

2020 ◽  
Vol 30 (3) ◽  
Author(s):  
Gholamreza Bahoush ◽  
Maryam Vafapour
Keyword(s):  
Differential Diagnosis ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Organ Failure ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
High Mortality ◽  
Occlusive Disease ◽  
Multi Organ Failure ◽  
Liver Injuries

Veno-occlusive disease (VOD) is one of the complications of hematopoietic stem cell transplantation that can also be caused by high-dose chemotherapy. This complication can lead to high mortality following bone marrow transplantation. It is more common after allogeneic stem cell transplantation, and is rare after autologous stem cell transplantation. While mild cases of VOD may reduce over a period of a few weeks, very severe cases can cause multi-organ damage, which has a high mortality. is therefore required with early diagnosis and treatment of this complication. In this paper, we present a sever VOD case after autologous stem cell transplantation, that was treated successfully with Defibrotide. The patient was a 14-month-old girl who has neuroblastoma with bone metastasis. VOD should be considered in the differential diagnosis of haematopoietic stem cell transplantation recipients who present with unexplained liver injuries, ascites and/or multi organ failure. Recipients of haematopoeitic stem cell transplantation who present with unexplained liver injuries, ascites and/or multi organ failure should have VOD considered in their differential diagnosis. If there is severe VOD diagnosed, then Defibrotide could be an option for treatment.

scholarly journals Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Julie Charles ◽  
Diane Giovannini ◽  
Nicolas Terzi ◽  
Carole Schwebel ◽  
Nathalie Sturm ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Organ Failure ◽  
Cell Transplantation ◽  
Multi Organ Failure

Hepatic veno-occlusive disease after tandem autologous stem cell transplantation conditioned by melphalan

2008 ◽  
Vol 88 (3) ◽  
pp. 291-293 ◽  
Author(s):  
Sana Intidhar Labidi ◽  
Catherine Sebban ◽  
Hervé Ghesquières ◽  
Emmanuele Virelizier Nicolas ◽  
Pierre Biron
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Occlusive Disease

scholarly journals Multiple septic emboli and myocardial infarction due to vaso-invasive Rhizomucor pusillus infection in a hematologic patient

2021 ◽  
pp. 227
Author(s):  
◽  
◽  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Organ Failure ◽  
Cell Transplantation ◽  
Adequate Treatment ◽  
Hematopoietic Stem ◽  
Rhizomucor Pusillus ◽  
Multi Organ Failure ◽  
Imaging Results

We present a case of a 63-year-old hematologic patient with pulmonary vaso-invasive zygomycosis with Rhizomucor pusillus after a second stem cell transplantation (SCT) for myelodysplastic syndrome, complicated by multi organ failure, myocardial ischemia and infarction. Zygomycosis is common in immunocompromised patients, especially after hematopoietic stem cell transplantation (HSCT). Mucor species have devastating vaso-invasive properties causing hematogenic dissemination. Antemortem diagnosis may be difficult due to negative cultures. Despite adequate treatment outcome tends to be poor. Cardiac zygomycosis is rare. In our patient, the clinical course and imaging results of the myocardial infarction are most consistent with coronary plaque rupture possibly provoked by severe vaso-invasive pulmonary infection and multi-organ failure.

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