scholarly journals Long-term complete remission of early hematological relapse after discontinuation of immunosuppressants following allogeneic transplantation for Sezary syndrome

2018 ◽  
Vol 10 (3) ◽  
Author(s):  
Hiroki Hosoi ◽  
Kazuo Hatanaka ◽  
Shogo Murata ◽  
Toshiki Mushino ◽  
Kodai Kuriyama ◽  
...  
Keyword(s):  
Stem Cell ◽  
Complete Remission ◽  
Clinical Course ◽  
Cell Lymphoma ◽  
Allogeneic Transplantation ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Cutaneous T Cell Lymphoma ◽  
Hematopoietic Stem

Sezary syndrome (SS) is a leukemic form of cutaneous T-cell lymphoma and is chemo-resistant. Allogeneic hematopoietic stem cell transplantation is a promising therapy for SS; however, relapse is common. Therapeutic options after relapse have not been established. We managed an SS patient with hematological relapse within one month after transplantation. After discontinuation of immunosuppressants, she achieved complete remission and remained relapse-free. The chimeric analyses of Tcells showed that the full recipient type became complete donor chimera after immunological symptoms. This clinical course suggested that discontinuation of immunosuppressants may result in a graftversus- tumor effect, leading to the eradication of lymphoma cells.

Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome

2019 ◽  
pp. 221-246
Author(s):  
Timothy J. Voorhees ◽  
Edith V. Bowers ◽  
Christopher R. Kelsey ◽  
Yara Park ◽  
Anne W. Beaven
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Cutaneous T Cell Lymphoma

Total Skin Electron Beam and Non-Myeloablative Allogeneic Hematopoietic Stem-Cell Transplantation in Advanced Mycosis Fungoides and Sézary Syndrome

2010 ◽  
Vol 28 (14) ◽  
pp. 2365-2372 ◽  
Author(s):  
Madeleine Duvic ◽  
Michele Donato ◽  
Bouthaina Dabaja ◽  
Heather Richmond ◽  
Lotika Singh ◽  
...  
Keyword(s):  
Electron Beam ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Cell Lymphoma ◽  
Chronic Gvhd ◽  
Complete Response ◽  
Cutaneous T Cell Lymphoma ◽  
Hematopoietic Stem

Purpose Transformed mycosis fungoides (MF) and Sézary syndrome (SS) are currently incurable. We studied the safety and efficacy of total skin electron beam with allogeneic hematopoietic stem-cell transplantation (HSCT) in patients with cutaneous T-cell lymphoma (CTCL). Patients and Methods Nineteen patients with advanced CTCL (median age, 50 years; four prior therapies) underwent total skin electron beam radiation followed by allogeneic HSCT between July 2001 and July 2008. Sixteen patients were conditioned with fludarabine (125 mg/m2) and melphalan (140 mg/m2) plus thymoglobulin (for mismatched donors). Graft-versus-host disease (GVHD) prophylaxis was with tacrolimus/mini methotrexate. Results Eighteen patients experienced engraftment, and one died as a result of sepsis on day 16. Median time to recovery of absolute neutrophil count (ANC) was 12 days. Fifteen achieved full donor chimerism, 12 had acute GVHD, and 12 were treated for chronic GVHD. The overall intent-to-treat response was 68%, and the complete response rate was 58%. Four of six patients died in complete remission as a result of bacterial sepsis (n = 2), chronic GVHD and fungal infection (n = 1), or lung cancer (n = 1); only two died as a result of progressive disease. Eight experienced relapse in skin; five regained complete response with reduced immunosuppression or donor lymphocyte infusions. Eleven of 13 are currently in complete remissions, with median follow-up of 19 months (range, 1.3 to 8.3 years). Median overall survival has not been reached. Conclusion Total skin electron beam followed by allogeneic stem-cell transplantation merits additional evaluation for a selected group of patients with refractory, advanced, cutaneous T-cell lymphoma with evidence for graft-versus-tumor effect.

Mycosis Fungoides/Sézary Syndrome Cutaneous T-Cell Lymphoma Quality of Life Instrument

2019 ◽  
Author(s):  
Stacey McCaffrey ◽  
Ryan A. Black ◽  
Mitchell Nagao ◽  
Marjan Sepassi ◽  
Gaurav Sharma ◽  
...  
Keyword(s):  
Quality Of Life ◽  
T Cell ◽  
Mycosis Fungoides ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Cutaneous T Cell Lymphoma ◽  
Life Instrument

Immunologic Differentiation of the Sézary Syndrome Due to Cutaneous T-Cell Lymphoma and Chronic Actinic Dermatitis

1986 ◽  
Vol 86 (2) ◽  
pp. 134-137 ◽  
Author(s):  
Anthony C Chu ◽  
Danielle Robinson ◽  
John L M Hawk ◽  
Robert Meacham ◽  
Margaret F Spittle ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Cutaneous T Cell Lymphoma ◽  
Chronic Actinic Dermatitis

Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome)

2014 ◽  
Vol 70 (2) ◽  
pp. 223.e1-223.e17 ◽  
Author(s):  
Sarah I. Jawed ◽  
Patricia L. Myskowski ◽  
Steven Horwitz ◽  
Alison Moskowitz ◽  
Christiane Querfeld
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Cutaneous T Cell Lymphoma
Sign in / Sign up

Export Citation Format

Share Document