scholarly journals Association between red cell distribution width and response to methotrexate in rheumatoid arthritis

Reumatismo ◽  
2020 ◽  
Vol 72 (1) ◽  
pp. 16-20 ◽  
Author(s):  
M. Bellan ◽  
D. Soddu ◽  
E. Zecca ◽  
A. Croce ◽  
R. Bonometti ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Treatment Response ◽  
Strong Predictor ◽  
Poor Response ◽  
Early Response ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Eular Response ◽  
Distribution Width

Red cell distribution width (RDW) is an unconventional biomarker of inflammation. We aimed to explore its role as a predictor of treatment response in rheumatoid arthritis (RA). Eighty-two RA patients (55 females), median age [interquartile range] 63 years [52-69], were selected by scanning the medical records of a rheumatology clinic, to analyze the associations between baseline RDW, disease activity scores and inflammatory markers, as well as the relationship between RDW changes following methotrexate (MTX) and treatment response. The lower the median baseline RDW, the greater were the chances of a positive EULAR response at three months, 13.5% [13.0-14.4] being among those with good response, vs 14.0% [13.2-14.7] and 14.2% [13.5- 16.0] (p=0.009) among those with moderate and poor response, respectively. MTX treatment was followed by a significant RDW increase (p<0.0001). The increase of RDW was greater among patients with good EULAR response, becoming progressively smaller in cases with moderate and poor response (1.0% [0.4-1.4] vs. 0.7 [0.1-2.0] vs. 0.3 [-0.1-0.8]; p=0.03). RDW is a strong predictor of early response to MTX in RA. RDW significantly increases after MTX initiation in parallel to treatment response, suggesting a role as a marker of MTX effectiveness.

scholarly journals SAT0111 RED CELL DISTRIBUTION WIDTH IS A MARKER OF EARLY RESPONSE TO METHOTREXATE IN RHEUMATOID ARTHRITIS

2019 ◽  
Author(s):  
Daniele Soddu ◽  
Mattia Bellan ◽  
Erika Zecca ◽  
Alessandro Croce ◽  
Roberta Pedrazzoli ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Early Response ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width

Is the red cell distribution width strong predictor for treatment response in primary glomerulonephritides?

Renal Failure ◽  
2014 ◽  
Vol 36 (7) ◽  
pp. 1083-1089 ◽  
Author(s):  
Kenan Turgutalp ◽  
Ahmet Kıykım ◽  
Simge Bardak ◽  
Serap Demir ◽  
Ümit Karabulut ◽  
...  
Keyword(s):  
Treatment Response ◽  
Strong Predictor ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width

Red cell distribution width is associated with endothelial progenitor cell depletion and vascular-related mediators in rheumatoid arthritis

2015 ◽  
Vol 240 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Javier Rodríguez-Carrio ◽  
Mercedes Alperi-López ◽  
Patricia López ◽  
Sara Alonso-Castro ◽  
Santiago Rubén Carro-Esteban ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Red Cell Distribution Width ◽  
Cell Depletion ◽  
Red Cell ◽  
Cell Distribution ◽  
Endothelial Progenitor ◽  
Distribution Width

Red cell distribution width and neutrophil–lymphocyte ratio in rheumatoid arthritis

2020 ◽  
Vol 40 (10) ◽  
pp. 1631-1637
Author(s):  
Patricia Pauline M. Remalante ◽  
Evelyn O. Salido ◽  
Ester G. Penserga ◽  
Deonne Thaddeus V. Gauiran
Keyword(s):  
Rheumatoid Arthritis ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Relationship between red cell distribution width and prognosis of patients with osteosarcoma

2019 ◽  
Vol 39 (12) ◽  
Author(s):  
Jian Zheng ◽  
Xiaopin Yuan ◽  
Weichun Guo
Keyword(s):  
Poor Prognosis ◽  
Survival Curve ◽  
Poor Response ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Poor Overall Survival ◽  
Distribution Width ◽  
Significant Difference

Abstract We retrospectively collected the clinical data and follow-up information of patients with osteosarcoma who were admitted to Department of Orthopedics, RenMin Hospital of Wuhan University from January 2010 to December 2016 and explore the relationship between red cell distribution width (RDW) and prognosis of patients with osteosarcoma. The present study finally included 271 patients with osteosarcoma with median follow-up time of 24.2 months (3–69 months). According to the RDW median, 135 patients belong to the low RDW group and 136 patients belong to high RDW group. Compared with low RDW group, the high RDW group tend to have metastasis (50 vs 32.6%, P=0.004), higher poor response rate to chemotherapy compared with the low RDW group (24.3 vs 7.4%, P=0.000) and higher C-reactive protein (CRP) (7.6 ± 4.9 vs 5.5 ± 4.5, t = 3.727, P=0.000). There was slightly significant difference in the types of pathology (χ2 = 8.059, P=0.045). The Kaplan–Meier analysis indicated survival curve of high RDW group was poorer than that in the low RDW group (P=0.020). The univariate cox analysis indicated that patients with RDW ≥ median had higher risk of poor prognosis compared with those who had RDW level &lt; median (HR = 2.41, 95% confidence interval (CI): 1.51–3.83, P=0.000). After adjusting some potential cofounding factors, the elevated RDW was still associated with poor prognosis (HR = 1.66, 95% CI: 1.07–2.56, P=0.024). The elevated pretreatment RDW was associated with poor overall survival (OS) in patients with osteosarcoma and can be an independent predictor of prognosis.

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