scholarly journals Relationship between red cell distribution width and prognosis of patients with osteosarcoma

2019 ◽  
Vol 39 (12) ◽  
Author(s):  
Jian Zheng ◽  
Xiaopin Yuan ◽  
Weichun Guo
Keyword(s):  
Poor Prognosis ◽  
Survival Curve ◽  
Poor Response ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Poor Overall Survival ◽  
Distribution Width ◽  
Significant Difference

Abstract We retrospectively collected the clinical data and follow-up information of patients with osteosarcoma who were admitted to Department of Orthopedics, RenMin Hospital of Wuhan University from January 2010 to December 2016 and explore the relationship between red cell distribution width (RDW) and prognosis of patients with osteosarcoma. The present study finally included 271 patients with osteosarcoma with median follow-up time of 24.2 months (3–69 months). According to the RDW median, 135 patients belong to the low RDW group and 136 patients belong to high RDW group. Compared with low RDW group, the high RDW group tend to have metastasis (50 vs 32.6%, P=0.004), higher poor response rate to chemotherapy compared with the low RDW group (24.3 vs 7.4%, P=0.000) and higher C-reactive protein (CRP) (7.6 ± 4.9 vs 5.5 ± 4.5, t = 3.727, P=0.000). There was slightly significant difference in the types of pathology (χ2 = 8.059, P=0.045). The Kaplan–Meier analysis indicated survival curve of high RDW group was poorer than that in the low RDW group (P=0.020). The univariate cox analysis indicated that patients with RDW ≥ median had higher risk of poor prognosis compared with those who had RDW level < median (HR = 2.41, 95% confidence interval (CI): 1.51–3.83, P=0.000). After adjusting some potential cofounding factors, the elevated RDW was still associated with poor prognosis (HR = 1.66, 95% CI: 1.07–2.56, P=0.024). The elevated pretreatment RDW was associated with poor overall survival (OS) in patients with osteosarcoma and can be an independent predictor of prognosis.

scholarly journals Association between red cell distribution width and response to methotrexate in rheumatoid arthritis

Reumatismo ◽  
2020 ◽  
Vol 72 (1) ◽  
pp. 16-20 ◽  
Author(s):  
M. Bellan ◽  
D. Soddu ◽  
E. Zecca ◽  
A. Croce ◽  
R. Bonometti ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Treatment Response ◽  
Strong Predictor ◽  
Poor Response ◽  
Early Response ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Eular Response ◽  
Distribution Width

Red cell distribution width (RDW) is an unconventional biomarker of inflammation. We aimed to explore its role as a predictor of treatment response in rheumatoid arthritis (RA). Eighty-two RA patients (55 females), median age [interquartile range] 63 years [52-69], were selected by scanning the medical records of a rheumatology clinic, to analyze the associations between baseline RDW, disease activity scores and inflammatory markers, as well as the relationship between RDW changes following methotrexate (MTX) and treatment response. The lower the median baseline RDW, the greater were the chances of a positive EULAR response at three months, 13.5% [13.0-14.4] being among those with good response, vs 14.0% [13.2-14.7] and 14.2% [13.5- 16.0] (p=0.009) among those with moderate and poor response, respectively. MTX treatment was followed by a significant RDW increase (p<0.0001). The increase of RDW was greater among patients with good EULAR response, becoming progressively smaller in cases with moderate and poor response (1.0% [0.4-1.4] vs. 0.7 [0.1-2.0] vs. 0.3 [-0.1-0.8]; p=0.03). RDW is a strong predictor of early response to MTX in RA. RDW significantly increases after MTX initiation in parallel to treatment response, suggesting a role as a marker of MTX effectiveness.

scholarly journals Red cell distribution width is associated with incident venous thromboembolism (VTE) and case-fatality after VTE in a general population

2015 ◽  
Vol 113 (01) ◽  
pp. 193-200 ◽  
Author(s):  
Jostein Lappegård ◽  
Tove Skjelbakken ◽  
Sigrid Brækkan ◽  
John-Bjarne Hansen ◽  
Trygve S. Ellingsen
Keyword(s):  
Venous Thromboembolism ◽  
General Population ◽  
Case Fatality ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
All Cause Mortality ◽  
Recurrent Vte

SummaryRecent studies suggest an association between red cell distribution width (RDW) and incident venous thromboembolism (VTE). We aimed to investigate the impact of RDW on risk of incident and recurrent VTE, and case-fatality, in a general population. RDW was measured in 26,223 participants enrolled in the Tromsø Study in 1994–1995. Incident and recurrent VTE events and deaths during follow-up were registered until January 1, 2012. Multivariate Cox proportional hazards regression models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI). There were 647 incident VTE events during a median of 16.8 years of follow-up. Individuals with RDW in the highest quartile (RDW≥13.3%) had 50% higher risk of an incident VTE than those in the lowest quartile (RDW≤12.3%). The association was strongest for unprovoked deep-vein thrombosis (HR highest vs lowest quartile of RDW: 1.8, 95% CI 1.1–3.1). VTE patients with baseline RDW≥13.3% had 30% higher risk of all-cause mortality after the initial VTE event than VTE patients with RDW<13.3%. There were no association between RDW and risk of recurrent VTE. Our findings suggest that high RDW is a risk factor of incident VTE, and that RDW is a predictor of all-cause mortality in VTE patients.

scholarly journals Is Red Cell Distribution Width a Marker for the Presence and Poor Prognosis of Cardiovascular Disease?

2012 ◽  
Vol 44 (3) ◽  
pp. 169-171 ◽  
Author(s):  
Turgay Isik ◽  
Erkan Ayhan ◽  
Ibrahim Halil Tanboga ◽  
Ahmet Kaya ◽  
Enbiya Aksakal ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Poor Prognosis ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width

Elevated red cell distribution width contributes to a poor prognosis in patients with esophageal carcinoma

2016 ◽  
Vol 452 ◽  
pp. 199-203 ◽  
Author(s):  
Guo-Xing Wan ◽  
Ping Chen ◽  
Xiao-Jun Cai ◽  
Lin-Jun Li ◽  
Xiong-Jie Yu ◽  
...  
Keyword(s):  
Esophageal Carcinoma ◽  
Poor Prognosis ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width

scholarly journals Comparison of Red Cell Distribution Width (RDW) Value in Congestive Heart Failure (CHF) Patients with Normal Persons

2021 ◽  
Vol 8 (8) ◽  
pp. 27-30
Author(s):  
Marhani Yunita ◽  
Herman Hariman
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Cardiac Dysfunction ◽  
Red Cell Distribution Width ◽  
Hematological Parameter ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Normal People ◽  
Significant Difference

Congestive Heart Failure (CHF) is a complex clinical symptom that is often characterized by structural abnormalities or cardiac dysfunction that impairs the ability of the left ventricle (LV) to fill or pump blood, especially during physical activity. Red Cell Distribution Width (RDW) is a simple, fast, inexpensive and direct hematological parameter, which reflects the level of anisocytosis in vivo. The association between impaired hematopoiesis and cardiac dysfunction is based on the fact that many different conditions are associated with increased heterogeneity of erythrocyte volume, which can be concurrently present in patients with heart failure, while anisocytosis can also directly contribute to the development and worsening of heart failure. This study aims to provide a comparison of RDW values between CHF patients and normal people. This study uses a case control study design where as many as 20 people with CHF will be compared their RDW values with 20 normal people. From a total of 40 patients, the average RDW value in CHF patients was 17.7±2.4 higher than the average RDW value for normal people was 12.6±0.4 and from the results of statistical analysis using the Independent Student t test obtained p value <0.001. There is a significant difference between the RDW values of CHF patients compared to normal people. Keywords: Congestive Heart Failure, CHF, Red Cell Distribution Width, RDW.

scholarly journals The predictive value of red cell distribution width for stroke severity and outcome

2020 ◽  
Author(s):  
Kavous Shahsavarinia ◽  
Younes Ghavam Laleh ◽  
Payman Moharramzadeh ◽  
Mahboob Pouraghaei ◽  
Elyar Sadeghi-Hokmabadi ◽  
...  
Keyword(s):  
Red Cell Distribution Width ◽  
Stroke Severity ◽  
Red Cell ◽  
Cell Distribution ◽  
Stroke Patients ◽  
Distribution Width ◽  
Significant Difference ◽  
Tissue Plasminogen ◽  
Insignificant Difference ◽  
The Mean

Abstract Objectives: In the present study, we sought to investigate the association between red cell distribution width (RDW) and stroke severity and outcome in patients who underwent anti-thrombolytic therapy with tissue plasminogen activator (tPA). Results: In this prospective study, 282 stroke patients who underwent tPA injection were included. The categorization of RDW to <12.9% and >13% values revealed insignificant difference in stroke severity score, accounting for the mean 36-hour NIHSS of 8.19±8.2 in normal RDW values and 9.94±8.28in higher RDW group (p=0.64). In seventh day, NIHSS was 6.46±7.28 in normal RDW group and was 8.52±8.35 in increased RDW group (p=0.058). Neither the thirty-six-hour, nor the seventh day and 3-month mRS demonstrated significant difference between those with normal and higher RDW values.

scholarly journals Elevated red cell distribution width to platelet count ratio predicts poor prognosis in patients with breast cancer

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hideya Takeuchi ◽  
Miyuki Abe ◽  
Yohei Takumi ◽  
Takafumi Hashimoto ◽  
Michiyo Miyawaki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Platelet Count ◽  
Poor Prognosis ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Count Ratio
Sign in / Sign up

Export Citation Format

Share Document