scholarly journals Response to Interferon-Free Direct Antivirals (DAAS) Treatment in HCV-Related Subcutaneous Lipoma-Like Marginal Zone B-Cell Lymphoma

2019 ◽  
Vol 11 (1) ◽  
pp. e2019053 ◽  
Author(s):  
Maria Lucia De Luca ◽  
Laura Lombardi ◽  
Germana Tartaglia ◽  
Francesca Fazio ◽  
Alessio Di Prima ◽  
...  
Keyword(s):  
B Cell ◽  
Antiviral Therapy ◽  
Virological Response ◽  
Marginal Zone ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Rare Entity ◽  
Direct Acting Antivirals ◽  
Direct Acting ◽  
Subcutaneous Lipoma

In 2010 a new entity termed “lipoma-like” HCV related marginal zone B-NHL was described. The etiological link between HCV infection and B-NHL has been extensively investigated in several epidemiological, biological and therapeutic studies and large experiences in literature demonstrated indolent lymphoma’s regression after antiviral therapy. HCV-related indolent NHL response to interferon-ribavirin-based antiviral therapy is well documented, while evidence of the efficacy of interferon-free direct-acting antivirals (DAAs) in this subset of lymphoma is also currently increasing. In this article we report two cases of HCV-related subcutaneous “lipoma-like” Marginal Zone B-cell lymphoma, treated with DAAs. Sustained virological response (SVR) with reduction of MZL localizations, persisting to date, were obtained in both patients. These data originally demonstrate the efficacy of DAAs in this rare entity.

scholarly journals Concomitant Treatment of Hepatitis C Virus and Diffuse Large B-Cell Lymphoma with Direct-Acting Antivirals in HIV Coinfection: A Case Report

2019 ◽  
Vol 18 ◽  
pp. 232595821882206
Author(s):  
Alyssa Gallipani ◽  
Agnes Cha ◽  
Leonard Berkowitz ◽  
Anjali Bakshi
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Concomitant Treatment ◽  
Direct Acting Antivirals ◽  
Large B Cell Lymphoma ◽  
Direct Acting ◽  
Large B Cell

This report describes a case of concomitant treatment of advanced diffuse large B-cell lymphoma with chemoimmunotherapy along with direct-acting antivirals for hepatitis C virus in a patient coinfected with HIV. The patient tolerated gemcitabine, dexamethasone, cisplatin, and rituximab and achieved sustained virologic response after treatment with ledipasvir/sofosbuvir.

Direct-acting antivirals in relapsed or refractory hepatitis C virus-associated diffuse large B-cell lymphoma

2020 ◽  
Vol 61 (9) ◽  
pp. 2122-2128 ◽  
Author(s):  
Michele Merli ◽  
Irene Defrancesco ◽  
Carlo Visco ◽  
Caroline Besson ◽  
Alice Di Rocco ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Direct Acting Antivirals ◽  
Large B Cell Lymphoma ◽  
Direct Acting ◽  
Large B Cell

scholarly journals Subcutaneous ‘lipoma-like’ B-cell lymphoma associated with HCV infection: a new presentation of primary extranodal marginal zone B-cell lymphoma of MALT

2010 ◽  
Vol 21 (6) ◽  
pp. 1189-1195 ◽  
Author(s):  
M. Paulli ◽  
L. Arcaini ◽  
M. Lucioni ◽  
E. Boveri ◽  
D. Capello ◽  
...  
Keyword(s):  
B Cell ◽  
Marginal Zone ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Hcv Infection ◽  
Subcutaneous Lipoma

scholarly journals Rare case of gastric extranodal marginal zone lymphoma

2021 ◽  
Vol 8 (4) ◽  
pp. 1316
Author(s):  
Devisha Raina
Keyword(s):  
B Cell ◽  
Marginal Zone ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Marginal Zone Lymphoma ◽  
Rare Entity ◽  
Marginal Zone B Cells ◽  
Non Hodgkin Lymphoma ◽  
Histiocytic Lymphoma ◽  
Zone Growth

True histiocytic lymphoma is considered a rare entity, and its diagnosis requires the concordance of morphological, immunophenotypic, and molecular findings. Gastric extra nodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) is a B-cell non-Hodgkin lymphoma that arises in the stomach and has a perifollicular/marginal zone growth pattern. The lymphoma is derived from marginal zone B-cells and recapitulates the architecture and organization of native MALT exemplified by the Peyers’ patches in the terminal ileum. Marginal zone lymphoma of MALT (MALT lymphoma) is the most common indolent subtype and represents 7% of all non-Hodgkin lymphomas.

Concomitant therapy with direct-acting antivirals and chemoimmunotherapy in HCV-associated diffuse large B-cell lymphoma

2019 ◽  
Vol 51 (5) ◽  
pp. 719-723 ◽  
Author(s):  
Vincenzo Occhipinti ◽  
Lucia Farina ◽  
Mauro Viganò ◽  
Marco Capecchi ◽  
Sara Labanca ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Direct Acting Antivirals ◽  
Concomitant Therapy ◽  
Large B Cell Lymphoma ◽  
Direct Acting ◽  
Large B Cell

scholarly journals Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Machiko Umemura ◽  
Goki Suda ◽  
Shihori Tsukamoto ◽  
Ko Ebata ◽  
Shinjiro Takahash ◽  
...  
Keyword(s):  
Hepatitis C ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Direct Acting Antivirals ◽  
On Demand ◽  
Large B Cell Lymphoma ◽  
First Case ◽  
Direct Acting ◽  
Large B Cell

Abstract Background In patients with hepatitis C virus (HCV) and malignant lymphoma, hepatitis C flare during R-CHOP can result in discontinuation of treatment. However, appropriate therapeutic strategies for managing hepatitis C flare during R-CHOP have not been established, and this issue is complicated by conflicting results regarding the use of direct-acting antivirals in patients with uncontrolled malignancies. Case presentation We report the first case of effective and safe treatment with on-demand 8-week glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in a patient with diffuse large B-cell lymphoma (DLBCL). The patient completed five additional courses of R-CHOP without hepatic toxicity. A complete response of DLBCL and a sustained virological response were observed at 24 weeks after glecaprevir and pibrentasvir completion. Conclusion On-demand, direct-acting antivirals could be a novel strategy for managing hepatitis C flare during R-CHOP.

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