scholarly journals The effect of a mixture of 2.7% sorbitol-0.54% mannitol solution on blood coagulation: an invitro, observational healthyvolunteer study using rotational thromboelastometry (ROTEM)

2019 ◽  
Vol 72 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Hyun-Jung Shin ◽  
Heijin Lee ◽  
Hyo-Seok Na
Keyword(s):  
Blood Coagulation ◽  
Rotational Thromboelastometry ◽  
Mannitol Solution

Amniotic fluid as a potent activator of blood coagulation and platelet aggregation: Study with rotational thromboelastometry

2018 ◽  
Vol 172 ◽  
pp. 142-149 ◽  
Author(s):  
Tomoaki Oda ◽  
Naoaki Tamura ◽  
Yi Shen ◽  
Yukiko Kohmura-Kobayashi ◽  
Naomi Furuta-Isomura ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Amniotic Fluid ◽  
Blood Coagulation ◽  
Rotational Thromboelastometry

The influence of excipients commonly used in freeze drying on whole blood coagulation dynamics assessed by rotational thromboelastometry

2015 ◽  
Vol 53 (10) ◽  
Author(s):  
Matthias Erber ◽  
Geoffrey Lee
Keyword(s):  
Blood Coagulation ◽  
Platelet Function ◽  
Active Compound ◽  
Whole Blood ◽  
Freeze Drying ◽  
Daily Basis ◽  
Bulking Agents ◽  
Rotational Thromboelastometry ◽  
Plasmatic Coagulation ◽  
Coagulation Dynamics

AbstractLyophilized reagents are used on a daily basis in coagulation diagnostics. They often contain a number of excipients in addition to the active compound. Some of these excipients may, however, influence coagulation dynamics.Besides from plasmatic coagulation bulking agents may influence platelet properties. We therefore studied the influence of a variety of bulking agents (glycine, mannitol, sucrose and trehalose) as well as a surfactant (TweenBoth disaccharides as well as TweenWhile the influence observed for glycine may be due to fibrinogen precipitation, the mechanism of mannitol appears to be more complex as platelet function as well as fibrin-based clot formation are influenced. This study therefore demonstrates the necessity to check for coagulation impairment due to compounds contained in lyophilized reagents.

scholarly journals Activation of Blood Coagulation After Aneurysmal Subarachnoid Hemorrhage: A Prospective Observational Trial of Rotational Thromboelastometry

2019 ◽  
Vol 122 ◽  
pp. e334-e341 ◽  
Author(s):  
Annukka S. Vahtera ◽  
Eija K. Junttila ◽  
L. Ville Jalkanen ◽  
Heini S. Huhtala ◽  
Ksenia V. Katanandova ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Blood Coagulation ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Rotational Thromboelastometry ◽  
Observational Trial
Sign in / Sign up

Export Citation Format

Share Document