The article provides a revision of the subfamily Hypoptinae, characterized by a common feature – a deeply split bifurcated uncus. Six new genera are described: Uretiana Yakovlev, Naydenov & Penco, gen.n. (type species − Givira vicuñensis Ureta, 1957), Dogniniya Yakovlev, Naydenov & Penco, gen.n. (type species − Hypopta sterila Dognin, 1910), Qhichwaruna Yakovlev, Naydenov & Penco, gen.n. (Type species − Qhichwaruna pennata Yakovlev, Naydenov & Penco, sp.n.), Wiraqucha Yakovlev, Naydenov & Penco, gen.n. (type species − Wiraqucha equadorica Yakovlev, Naydenov & Penco, sp.n.), Thonyocossus Yakovlev, Naydenov & Penco, gen.n. (type species − Thonyocossus brasiliensis Yakovlev, Naydenov & Penco, sp.n.), Hastam Yakovlev, Naydenov & Penco, gen.n. (type species – Hastam gracilis Yakovlev, Naydenov & Penco, sp.n.) and eight new species: Uretiana tucumana Yakovlev, Naydenov & Penco, sp.n. (type locality − Argentina, prov. Tucuman), Dogniniya lemoulti Yakovlev, Naydenov & Penco, sp.n. (type locality − Uypiranga, Bresil), D. huanuco Yakovlev, Naydenov & Penco, sp.n. (type locality − Peru, prov. Huánuco, Yayapichis, ACP Panguana, 9°36″S / 74°56″W), Qhichwaruna argentinensis Yakovlev, Naydenov & Penco, sp.n. (type locality − Argentinien, Cafayate, Prov. Catamarca), Wiraqucha huberti Yakovlev, Naydenov & Penco, sp.n. (type locality − Brasilien, Minas Gerais Poté), W. equadorica Yakovlev, Naydenov & Penco, sp.n. (type locality − Ecuador oriente Napo Rte Cosanga-Tena PK 18), Thonyocossus brasiliensis Yakovlev, Naydenov & Penco, sp.n. (type locality − Brasilien, Minas Gerais Poté), Hastam gracilis Yakovlev, Naydenov & Penco, sp.n. (type locality − Brasilien, Esp. Santo, Santa Leopoldina, Boquerao). New combinations are established: Uretiana vicunensis (Ureta, 1957), comb.n., Uretiana infans (Dyar & Schaus, 1937), comb.n., Dogniniya sterila (Dognin, 1910), comb. n. and Dogniniya beatrix (Schaus, 1921), comb. n.