Time-domain versus spectral-domain optical  coherence tomography: Findings in acute central  serous chorioretinopathy*

Aims: To evaluate the optic coherence tomographic (OCT) features in acute central serous chorioretinopathy (ACSC) with time-domain or spectral-domain OCT at Dokuz Eylul University, Department of Ophthalmology, Izmir, Turkey.Subjects and Methods: Clinical data from the Department of Ophthalmology (of Dokuz Eylul University) including fluorescein angiography (FA) and OCT findings of 39 eyes of 34 patients with ACSC were retrospectively analyzed. Eleven eyes (Ntd =11) were examined with time-domain (Stratus OCT 3, Version 4.0) and 28 eyes (Nsd =28) with spectral-domain OCT (Heidelberg HRA2 Spectralis).Results: Of the sample of 34, twenty-four patients (70.6%) were men and 10 women (29.4%). FA demonstrated smokestack type hyperfluorescence in five eyes (12.8%), a round ink blot type hyperfluorescence in 32 eyes (82.1%) and diffuse leak-age in two (5.1%) eyes. Twenty-five eyes (64.1%) had only one leakage site, five eyes (12.8%) hadtwo leakage sites and nine eyes (23.1%) had three or more leakage sites. Detachment of the neurosensory retina was detected in 37 eyes (94.9%, 11 eyes with Stratus OCT and 26 eyes with Spectral OCT). Pigment epithelial detachment (PED) was detected in nine eyes (23.1%, one eye with Stratus OCT and eight eyes with Spectral OCT). Protrusion of the RPE layer was detected in 10 eyes (25.6%, all eyes with Spectral OCT). Both fibrinous exudates and bridging between the neurosensory retina and PED was detected with Spectral OCT in four eyes (10.2%). Retinal dipping was detected with Spectral OCT in two eyes (5.1%).Conclusion: Spectral-domain OCT seems to yield more information and depicts RPE layer protrusion, fibrinous exudates and bridging better when compared to conventional time-domain OCT. (S Afr Optom 2012 71(4) 166-170)

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Acute central serous chorioretinopathy: a correlation study between fundus autofluorescence and spectral-domain OCT

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-014-2899-5 ◽

2015 ◽

Vol 253 (11) ◽

pp. 1889-1897 ◽

Cited By ~ 23

Author(s):

Pierluigi Iacono ◽

Parodi Maurizio Battaglia ◽

Alexandros Papayannis ◽

Carlo La Spina ◽

Monica Varano ◽

...

Keyword(s):

Central Serous Chorioretinopathy ◽

Fundus Autofluorescence ◽

Correlation Study ◽

Spectral Domain ◽

Spectral Domain Oct ◽

Acute Central Serous Chorioretinopathy

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Comparison between time-domain and spectral-domain OCT in the detection of retinal nerve fiber layer defects in glaucoma patients

International Eye Research ◽

10.18240/ier.2020.02.05 ◽

2020 ◽

Vol 1 (2) ◽

pp. 89-94

Author(s):

Jae Keun Chung ◽

Keyword(s):

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Time Domain ◽

Spectral Domain ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Spectral Domain Oct ◽

Spectralis Oct ◽

Stratus Oct ◽

Retinal Nerve Fiber

AIM: To compare, using the instruments’ built-in normative databases, the sensitivities of time-domain optical coherence tomography (Stratus OCT) and spectral-domain OCT (Spectralis OCT) in the detection of retinal nerve fiber layer (RNFL) defects in patients with glaucoma. METHODS: Fifty-two eyes of 35 patients with open angle glaucoma were included. A total of 69 hemiretinas with photographically identified RFNL defects were analyzed using the fast RNFL scan of Stratus OCT and the circle scan in Spectralis OCT. The OCT parameters were evaluated at 5% and 1% abnormality levels using the instruments’ built-in normative databases. The diagnostic sensitivity of each parameter was compared between the two devices. RESULTS: The Spectralis OCT detected RNFL defects within each quadrant more frequently than the Stratus OCT at both the 5% (79.7% vs 63.8%, P=0.01) and 1% (56.5% vs 40.6%, P=0.01) abnormality levels. At the 1% abnormality level, the sensitivity was significantly higher in the standard sector of Spectralis OCT than in the clock-hour sector of the Stratus OCT (68.1% vs 39.1%, P<0.01).

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Comparison of time domain Stratus OCT and spectral domain SLO/OCT for assessment of macular thickness and volume

Eye ◽

10.1038/eye.2008.363 ◽

2008 ◽

Vol 23 (11) ◽

pp. 2071-2078 ◽

Cited By ~ 57

Author(s):

R Forte ◽

G L Cennamo ◽

M L Finelli ◽

G de Crecchio

Keyword(s):

Time Domain ◽

Macular Thickness ◽

Spectral Domain ◽

Stratus Oct

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Detection of graft detachments immediately following Descemet membrane endothelial keratoplasty (DMEK) comparing time domain and spectral domain OCT

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-016-3484-x ◽

2016 ◽

Vol 254 (12) ◽

pp. 2431-2437 ◽

Cited By ~ 10

Author(s):

Sebastian Siebelmann ◽

Uta Gehlsen ◽

Carolin Le Blanc ◽

Tisha Prabriputaloong Stanzel ◽

Claus Cursiefen ◽

...

Keyword(s):

Time Domain ◽

Spectral Domain ◽

Endothelial Keratoplasty ◽

Descemet Membrane Endothelial Keratoplasty ◽

Descemet Membrane ◽

Spectral Domain Oct

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Morphological changes in the retinal pigment epithelium on spectral-domain OCT in the unaffected eyes with idiopathic central serous chorioretinopathy

International Ophthalmology ◽

10.1007/s10792-009-9302-2 ◽

2009 ◽

Vol 30 (2) ◽

pp. 175-181 ◽

Cited By ~ 42

Author(s):

Pawan Gupta ◽

Vishali Gupta ◽

M. R. Dogra ◽

Ramandeep Singh ◽

Amod Gupta

Keyword(s):

Retinal Pigment Epithelium ◽

Central Serous Chorioretinopathy ◽

Morphological Changes ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Spectral Domain ◽

Spectral Domain Oct

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Stratus OCT image analysis with spectral-domain OCT (Topcon 3D OCT Viewer)

British Journal of Ophthalmology ◽

10.1136/bjo.2010.193144 ◽

2011 ◽

Vol 96 (1) ◽

pp. 93-98 ◽

Cited By ~ 1

Author(s):

Seong-Woo Kim ◽

Jaeryung Oh ◽

Kyung-Sook Yang ◽

Young Ho Kim ◽

Jin Whan Park ◽

...

Keyword(s):

Image Analysis ◽

Spectral Domain ◽

Spectral Domain Oct ◽

Stratus Oct ◽

Oct Image

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Imaging of the Retinal Nerve Fibre Layer with Spectral-domain Optical Coherence Tomography in Patients with Glaucoma

European Ophthalmic Review ◽

10.17925/eor.2010.04.01.17 ◽

2010 ◽

Vol 04 (01) ◽

pp. 17

Author(s):

Antonio Ferreras ◽

Luis E Pablo ◽

◽

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fibre ◽

Time Domain ◽

Retinal Nerve Fibre Layer ◽

Spectral Domain ◽

Optical Coherence ◽

Spectral Domain Oct ◽

Fibre Layer ◽

Diagnostic Potential ◽

Nerve Fibre Layer

Evaluation of the retinal nerve fibre layer (RNFL) is key to diagnosing and monitoring changes in glaucoma. Optical coherence tomography (OCT) is a non-invasive, objective, quantitative method that provides realtimein vivoimages of the retina. The new spectral-domain OCTs have increased resolution and acquisition speed compared with earlier time-domain OCTs, enabling the generation of highly detailed 3D images. Axial resolution has also been improved from 10 to 3–5μm. Thus, spectral-domain OCT is a promising new clinical tool for evaluating the RNFL in glaucoma and other retinal diseases. Recent studies report that spectral-domain OCT provides peri-papillary RNFL measurements with excellent repeatability and reproducibility. The reduced variability compared with time-domain OCT may improve detection of disease progression in glaucoma patients. In cross-sectional studies, most authors suggest that the two OCT systems have similar diagnostic potential to discriminate between healthy and glaucoma patients. Nevertheless, the Cirrus HD-OCT (spectral-domain) tends to yield a slightly higher sensitivity at fixed specificities than the Stratus OCT (time-domain) for glaucoma diagnosis. In healthy subjects and patients with glaucoma, RNFL thickness measurements acquired with the two OCT systems correlated well, but their values cannot be used interchangeably.

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