Structure–Function Correlations in Glaucoma Using Matrix and Standard Automated Perimetry Versus Time-Domain and Spectral-Domain OCT Devices

Aims: To evaluate the optic coherence tomographic (OCT) features in acute central serous chorioretinopathy (ACSC) with time-domain or spectral-domain OCT at Dokuz Eylul University, Department of Ophthalmology, Izmir, Turkey.Subjects and Methods: Clinical data from the Department of Ophthalmology (of Dokuz Eylul University) including fluorescein angiography (FA) and OCT findings of 39 eyes of 34 patients with ACSC were retrospectively analyzed. Eleven eyes (Ntd =11) were examined with time-domain (Stratus OCT 3, Version 4.0) and 28 eyes (Nsd =28) with spectral-domain OCT (Heidelberg HRA2 Spectralis).Results: Of the sample of 34, twenty-four patients (70.6%) were men and 10 women (29.4%). FA demonstrated smokestack type hyperfluorescence in five eyes (12.8%), a round ink blot type hyperfluorescence in 32 eyes (82.1%) and diffuse leak-age in two (5.1%) eyes. Twenty-five eyes (64.1%) had only one leakage site, five eyes (12.8%) hadtwo leakage sites and nine eyes (23.1%) had three or more leakage sites. Detachment of the neurosensory retina was detected in 37 eyes (94.9%, 11 eyes with Stratus OCT and 26 eyes with Spectral OCT). Pigment epithelial detachment (PED) was detected in nine eyes (23.1%, one eye with Stratus OCT and eight eyes with Spectral OCT). Protrusion of the RPE layer was detected in 10 eyes (25.6%, all eyes with Spectral OCT). Both fibrinous exudates and bridging between the neurosensory retina and PED was detected with Spectral OCT in four eyes (10.2%). Retinal dipping was detected with Spectral OCT in two eyes (5.1%).Conclusion: Spectral-domain OCT seems to yield more information and depicts RPE layer protrusion, fibrinous exudates and bridging better when compared to conventional time-domain OCT. (S Afr Optom 2012 71(4) 166-170)

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COMPARATIVE STUDY OF RNFL THICKNESS USING SPECTRAL DOMAIN OCT AND VISUAL FIELD ANALYSIS USING HUMPHREY FIELD ANALYSER IN CASES OF POAG

10.36106/ijar/2704711 ◽

2021 ◽

pp. 62-64

Author(s):

Samra Wahaj Fatima ◽

M M M Baig ◽

Superna Mahender ◽

M. Geetanjali ◽

Mohammed Ather

Keyword(s):

Comparative Study ◽

Field Analysis ◽

Spectral Domain ◽

Automated Perimetry ◽

Care Hospital ◽

Slit Lamp ◽

Spectral Domain Oct ◽

Rnfl Thickness ◽

Field Analyser ◽

Sd Oct

Purpose: To compare RNLF structural changes by Spectral Domain- OCT and functional visual eld defects by automated perimetry in Primary Open Angle Glaucoma cases Materials And Methods: A prospective and comparative study was conducted to quantitatively measure the peripapillary retinal nerve ber layer thickness using SD-OCT and compared it with eld changes plotted by Humphrey Field analyser 24-2. The study was conducted at the department of Glaucoma of a tertiary eye care hospital for a period of one year. 60 eyes of 30 patients who diagnosed to have POAG between the age group of 40-65 were included in the study. Patients having substantial media opacity, Retinal pathology and who underwent intra ocular surgeries were excluded from the study. Informed consent obtained from patients who were included in the study. All were examined using Slit lamp, Snellen's chart, Applanation tonometer, Gonioscope, 90 D slit lamp biomicroscope to study Fundus oculi. Fields were plotted using Humphrey eld analyser 24-2 , RNFL thickness measured using SD-OCT. Results: 60 eyes of 30 patients 19 were males 11 were females. 14(23.33%) eyes showed normal visual elds but there was thinning of RNFL was noted in SD-OCT. 41 eyes (68.3%) had visual eld defects which corresponded to thinning of RNFL in that quadrant. 5 eyes (8.3%) showed advanced eld changes and had corresponding thinning of RNFL in that quadrant. Discussion: Results of this study shows a signicant difference in RNFL thickness among all three grades of glaucoma. It was observed that the average RNFL thickness value in moderate glaucoma (66.34 microns) and all quadrant thickness values were similar to Sihota et al study (RNFL-66.07 microns). The mean RNFL thickness +/- Sd (58 +/-5.52) in advanced glaucoma of present study were closely similar with the ndings of Sihota et al study (53.65 +/-14.2). Conclusion: It is concluded that RNFL thickness changes corresponds to Field changes plotted on Humphrey eld analyser in moderate glaucoma. Even in mild cases changes RNFL thickness is noted even though the elds plotted on Humphrey eld analyser doesn't show any changes. So RNFL thickness can be taken as Pre perimetric changes as diagnostic criteria for the diagnosis of POAG.

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Imaging of the Retinal Nerve Fibre Layer with Spectral-domain Optical Coherence Tomography in Patients with Glaucoma

European Ophthalmic Review ◽

10.17925/eor.2010.04.01.17 ◽

2010 ◽

Vol 04 (01) ◽

pp. 17

Author(s):

Antonio Ferreras ◽

Luis E Pablo ◽

◽

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fibre ◽

Time Domain ◽

Retinal Nerve Fibre Layer ◽

Spectral Domain ◽

Optical Coherence ◽

Spectral Domain Oct ◽

Fibre Layer ◽

Diagnostic Potential ◽

Nerve Fibre Layer

Evaluation of the retinal nerve fibre layer (RNFL) is key to diagnosing and monitoring changes in glaucoma. Optical coherence tomography (OCT) is a non-invasive, objective, quantitative method that provides realtimein vivoimages of the retina. The new spectral-domain OCTs have increased resolution and acquisition speed compared with earlier time-domain OCTs, enabling the generation of highly detailed 3D images. Axial resolution has also been improved from 10 to 3–5μm. Thus, spectral-domain OCT is a promising new clinical tool for evaluating the RNFL in glaucoma and other retinal diseases. Recent studies report that spectral-domain OCT provides peri-papillary RNFL measurements with excellent repeatability and reproducibility. The reduced variability compared with time-domain OCT may improve detection of disease progression in glaucoma patients. In cross-sectional studies, most authors suggest that the two OCT systems have similar diagnostic potential to discriminate between healthy and glaucoma patients. Nevertheless, the Cirrus HD-OCT (spectral-domain) tends to yield a slightly higher sensitivity at fixed specificities than the Stratus OCT (time-domain) for glaucoma diagnosis. In healthy subjects and patients with glaucoma, RNFL thickness measurements acquired with the two OCT systems correlated well, but their values cannot be used interchangeably.

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