Ischemia Modified Albumin and miR-126 Play Important Role in Diagnosis of Posterior Circulation Transient Ischemic Attack and Prediction of Secondary Cerebral Infarction

Symptomatic atherosclerotic intracranial artery stenosis often causes ischemic cerebral infarction or transient ischemic attack in the stenosis area. Early detection of cerebral infarction and evaluation of ischemic penumbra and hemodynamics in the infarct area Information plays an extremely important role in clinical treatment and prognosis. This article briefly introduces the application of multimodal MRI in cerebral infarction.

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Predictors of cerebral infarction following transient ischemic attack

Journal of Stroke and Cerebrovascular Diseases ◽

10.1016/s1052-3057(10)80129-6 ◽

1993 ◽

Vol 3 (1) ◽

pp. 23-28 ◽

Cited By ~ 4

Author(s):

Askiel Bruno ◽

Lynn Jeffries ◽

Elizabeth LaKind ◽

Clifford Qualls

Keyword(s):

Cerebral Infarction ◽

Transient Ischemic Attack ◽

Ischemic Attack

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Lipoprotein abnormalities in the pathogenesis of cerebral infarction and transient ischemic attack.

Stroke ◽

10.1161/01.str.12.2.167 ◽

1981 ◽

Vol 12 (2) ◽

pp. 167-172 ◽

Cited By ~ 42

Author(s):

A Murai ◽

T Tanaka ◽

T Miyahara ◽

M Kameyama

Keyword(s):

Cerebral Infarction ◽

Transient Ischemic Attack ◽

Ischemic Attack

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Association of serum levels of antibodies against ALDOA and FH4 with transient ischemic attack and cerebral infarction

10.21203/rs.3.rs-18584/v2 ◽

2020 ◽

Author(s):

Hao Wang ◽

Hao Lu ◽

Xiao-Meng Zhang ◽

Ken-ichiro Goto ◽

Eiichi Kobayashi ◽

...

Keyword(s):

Cerebral Infarction ◽

Transient Ischemic Attack ◽

Serum Antibody ◽

Fumarate Hydratase ◽

Multivariate Logistic Regression Analysis ◽

Intima Media Thickness ◽

Human Aortic Endothelial Cell ◽

Atherosclerotic Stenosis ◽

Ischemic Attack ◽

Antibody Levels

Abstract Background: Ischemic stroke, such as transient ischemic attack (TIA) and acute-phase cerebral infarction (aCI) , are the serious problems in the aging society. Therefore, development of biomarkers for TIA and aCI are attempted. Methods: Candidate antigens recognized by IgG autoantibodies in the serum of 19 TIA patients were screened by a human aortic endothelial cell cDNA library. Serum antibody levels against the antigens were examined by amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) in healthy donor (HD), TIA, and aCI cohorts ( n = 285, 92 and 529). The antibody levels in the sera of the Japan Public Health Center-based Prospective Cohort Study (JPHC) from 1991 to 1993 was also examined. Results: Aldolase A, fructose-bisphosphate (ALDOA) and fumarate hydratase (FH) were identified as the candidate antigens. AlphaLISA revealed that the levels of anti-ALDOA antibodies (ALDOA-Abs) and anti-FH antibodies (FH-Abs) were both higher in patients with TIA or aCI than those in HDs ( P < 0.05). The levels of ALDOA-Abs [odds ratio (OR): 2.46, P = 0.0050] and FH-Abs (OR: 2.49, P = 0.0037) were independent predictors of TIA by multivariate logistic regression analysis. The case-control study showed the levels of ALDOA-Abs (OR: 2.50, P < 0.01) and FH-abs (OR: 2.60, P < 0.01) were associated with risk of aCI. Correlation analysis demonstrated that both ALDOA-Abs and FH-Abs were well associated with hypertension, coronary heart disease and habitual smoking. These antibody levels were also correlated well with maximum intima-media thickness, which reflects atherosclerotic stenosis. Conclusions: ALDOA-Abs and FH-Abs can serve as novel potential biomarkers for prediction of atherosclerotic TIA and aCI.

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Prognosis for Patients Following a Transient Ischemic Attack With and Without a Cerebral Infarction on Brain CT

Neurology ◽

10.1212/wnl.45.3.428 ◽

1995 ◽

Vol 45 (3) ◽

pp. 428-431 ◽

Cited By ~ 35

Author(s):

M. Eliasziw ◽

J. Y. Streifler ◽

J. D. Spence ◽

A. J. Fox ◽

V. C. Hachinski ◽

...

Keyword(s):

Cerebral Infarction ◽

Transient Ischemic Attack ◽

Brain Ct ◽

Ischemic Attack

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Abstract TP174: Nonfocal Symptoms in Patients With Transient Ischemic Attack: The PROMISE-TIA Registry

Stroke ◽

10.1161/str.48.suppl_1.tp174 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Toshiya Ishihara ◽

Shoichiro Sato ◽

Toshiyuki Uehara ◽

Tomoyuki Ohara ◽

Mikito Hayakawa ◽

...

Keyword(s):

Heart Disease ◽

Ischemic Stroke ◽

Ischemic Heart Disease ◽

Transient Ischemic Attack ◽

Posterior Circulation ◽

Ischemic Heart ◽

Arterial Stenosis ◽

Unique Identifier ◽

Clinical Trial Registration ◽

Ischemic Attack

Background and purpose: Patients with transient ischemic attack (TIA) occasionally accompany nonfocal symptoms, such as decreased consciousness, confusion, amnesia, and unsteadiness. The purpose of this study was to clarify characteristics and prognosis of TIA patients having nonfocal symptoms, using data of the PROspective Multicenter registry to Identify Subsequent cardiovascular Events after TIA (PROMISE-TIA). Methods: Patients with TIA within 7 days of onset were consecutively enrolled in the Japanese nationwide registry. Factors associated with nonfocal symptoms and 1-year risk of ischemic stroke and ischemic heart disease were assessed in logistic regression and Kaplan-Meier models, respectively. Results: We studied 1348 patients with TIA (871 men, mean age of 69.4±12.4 years). Two hundred and nineteen patients (16%) had nonfocal symptoms. Patients with nonfocal symptoms were more likely to have both diffusion-weighted imaging (DWI)-positive lesions and stenosis/occlusion on vascular examination (magnetic resonance/computed tomographic angiography, or carotid ultrasound) in posterior circulation than those without (11% vs. 4%, p<0.001, 20% vs. 11%, p<0.001), but were otherwise broadly similar with respect to other baseline characteristics. Although 1-year risk of ischemic stroke was not different between the two groups (7.5% vs. 8.2%, p=0.756), the risk of ischemic heart disease was higher in patients with nonfocal symptoms (3.1% vs. 1.2%, p=0.046). Conclusions: Both ischemic changes and arterial stenosis/occlusion in posterior circulation were more frequently observed in TIA patients with nonfocal symptoms and they seem to be at high risk of ischemic heart disease. Clinical Trial Registration: URL: http://www.clinicaltraial.gov . Unique identifier: NCT01581502.

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The Effect of Intravenous Thrombolysis on Transient Ischemic Attack and Cerebral Infarction Patients Under the Guidance of Multimodal Magnetic Resonance Imaging

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2021.3324 ◽

2021 ◽

Vol 11 (2) ◽

pp. 590-594

Author(s):

Aixia Song ◽

Jing Chen ◽

Yan Sun ◽

Xiaoqin Wang ◽

Jichao Zhang ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Cerebral Infarction ◽

Thrombolytic Therapy ◽

Transient Ischemic Attack ◽

Intravenous Thrombolysis ◽

Resonance Imaging ◽

Neurological Prognosis ◽

Multimodal Mri ◽

Ischemic Attack

Objective: To investigate the clinical effects of intravenous thrombolysis in the treatment of TIA (Transient Ischemic Attack) and cerebral infarction with multimodal MRI (magnetic resonance imaging), and to provide a reference for clinical diagnosis and treatment. Methods: Patients with acute cerebral infarction diagnosed and treated with intravenous thrombolysis were enrolled in the study. Multimodal MRI was performed to determine the location and type of cerebral infarction. Based on routine treatment and care, the rt-PA (Recombinant Tissue Plasminogen Activator) intravenous thrombolytic therapy was applied. The NIHSS (National Institutes of Health Stroke Scale) scores of patients before and after treatment were evaluated and compared to analyze the neurological prognosis. Results: The NIHSS scores after treatment were significantly lower than those before treatment, and the neurological prognosis was good. Three different forms of ACVS (asymmetric cortical venous signs) after treatment could be observed by SWI (drug-sensitive weighted imaging) images, which could help to assess the prognosis. Conclusion: Multimodal MRI could evaluate the type and severity of acute cerebral infarction. The rt-PA intravenous thrombolytic therapy could effectively promote the recovery of neurological functions in patients with cerebral infarction, which was worthy of clinical promotion.

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Evaluation and Management of Transient Ischemic Attack and Minor Cerebral Infarction

Mayo Clinic Proceedings ◽

10.4065/79.8.1071 ◽

2004 ◽

Vol 79 (8) ◽

pp. 1071-1086 ◽

Cited By ~ 19

Author(s):

Kelly D. Flemming ◽

Robert D. Brown ◽

George W. Petty ◽

John Huston ◽

David F. Kallmes ◽

...

Keyword(s):

Cerebral Infarction ◽

Transient Ischemic Attack ◽

Ischemic Attack

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Strategy and effect of repeat bypass surgery for anterior/posterior circulation in refractory moyamoya disease

Journal of Neurosurgery ◽

10.3171/2019.3.jns181979 ◽

2020 ◽

Vol 132 (6) ◽

pp. 1889-1899

Author(s):

Haruto Uchino ◽

Daina Kashiwazaki ◽

Naoki Akioka ◽

Masaki Koh ◽

Naoya Kuwayama ◽

...

Keyword(s):

Moyamoya Disease ◽

Cerebral Artery ◽

Transient Ischemic Attack ◽

Bypass Surgery ◽

Posterior Circulation ◽

Therapeutic Effects ◽

Anterior Circulation ◽

Group A ◽

Ischemic Attack ◽

Group B

OBJECTIVEIn this study the authors aimed to describe clinical features, surgical techniques, and long-term outcomes of repeat bypass surgery required for a certain subset of patients with moyamoya disease.METHODSThe authors retrospectively reviewed a total of 22 repeat bypass surgeries for 20 patients (age range 1–69 years) performed during the last 20 years at their institutions. The patients were classified into 2 groups. Group A included 10 patients who underwent repeat bypass surgery for anterior circulation due to insufficient revascularization on the ipsilateral side. Group B included 10 patients who underwent repeat bypass surgery for posterior circulation due to the involvement of the posterior cerebral artery (PCA) after successful initial surgery for anterior circulation.RESULTSPreoperative symptoms included headache in 3 patients, transient ischemic attack in 10, cerebral infarction in 3, and intracranial hemorrhage in 4 patients. Intervals between the initial bypass surgery and repeat bypass surgery were 0.3–30 years (median 3 years). In group A, superficial temporal artery to middle cerebral artery (MCA) anastomosis and indirect bypass were performed on 7 hemispheres. Only indirect bypass was performed on 3 hemispheres because of the lack of suitable donor or recipient arteries. In group B, occipital artery (OA) to PCA anastomosis and indirect bypass were conducted on 4 hemispheres, and OA-MCA anastomosis and indirect bypass on 1 hemisphere. Only indirect bypass was conducted on 7 hemispheres because of the lack of suitable recipient arteries. All 22 repeat bypass surgeries were successfully conducted. During follow-up periods (median 4 years), none of the patients suffered repeat stroke except 1 patient who died of recurrent intracerebral hemorrhage 3 years after repeat bypass surgery for anterior circulation.CONCLUSIONSRepeat bypass surgery was feasible and effective to reduce further incidence of headache attack, transient ischemic attack, and ischemic/hemorrhagic stroke in moyamoya disease patients. Through precise radiological analysis, surgical procedures should be planned to yield maximal therapeutic effects.

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