scholarly journals Combination treatment of low fluence photodynamic therapy and intravitreal ranibizumab for choroidal neovascular membrane secondary to angioid streaks in Paget′s disease - 12 month results

2011 ◽  
Vol 59 (4) ◽  
pp. 306 ◽  
Author(s):  
RodneyJ Morris ◽  
ParagK Shah ◽  
V Narendran ◽  
VarshaV Prabhu

At the point when the eye experiences choroidal neovascularization, scar, or both, at the hour of treatment, the pace of repeat was 65% versus 33% if the concerned eye had no choroidal neovascularization, scar, or both. Normally a visual sharpness of four lines is lost when individual eyes had choroidal neovascularization, scar, or both, versus one line when the individual eye had no choroidal neovascularization or mark. Photocoagulation of choroidal neovascularization using LASER in patients experiencing angioid streaks can cause the ending of the choroidal neovascularization and adjustment of visual keenness. Treatment of choroidal neovascular membranes (CNVM) can differ depending on the concerned disease. Treatment consists of thermal laser treatment, anti-VEGF drugs, photodynamic therapy (PDT). Contingent upon the advancement of the illness, the individual may get at least one of these therapeutic treatment. Laser treatment is generally done as an outpatient strategy. It happens in the eye specialist's office or at the hospital. The LASER beam utilized in this treatment is a focused light having high energy.[5] It obliterates the abnormal blood veins, anticipating further spillage, dying, and development. After the laser treatment, vision may turn out to be more obscured than previously. Be that as it may, frequently it will balance out inside half a month. The treatment brings about a perpetual scar, making a lasting vulnerable side. This came about vulnerable sides, may be perceptible in the field of vision. Generally in the LASER treatment anomalous veins are demolished. In any case, patients regularly need re-treatment inside three to five years.


Author(s):  
Rituparna Ghoshal ◽  
Sharanjeet Sharanjeet-Kaur ◽  
Norliza Mohamad Fadzil ◽  
Somnath Ghosh ◽  
Nor Fariza Ngah ◽  
...  

The objective of this study was to compare visual parameters and retinal layers’ morphology pre-treatment (baseline) and 6 months post-treatment in polypoidal choroidal vasculopathy (PCV) eyes. A single centre, longitudinal, prospective study was conducted at a public tertiary hospital of Malaysia. Visual parameters including distance and near visual acuity (DVA and NVA), contrast sensitivity (CS), reading speed (RS), and different qualitative and quantitative optical coherence tomography (OCT) parameters were evaluated pre- and 6 months post-treatment. Thirty-three naïve PCV eyes of 32 patients (mean age of 67.62 years) were evaluated pre- and post-treatment of intravitreal ranibizumab with and without photodynamic therapy. After treatment, sub retinal fluid decreased from 27 eyes (84.35%) at baseline to 7 eyes (21.88%) at 6 months while pigment epithelium detachment decreased from 32 eyes (100%) at base line to 15 eyes (46.87%) at 6 months. Mean pre-treatment quantitative morphological OCT retinal parameters including thickness and volume of central sub field, center thickness, center minimum, and maximum thickness reduced significantly. Similarly, all visual parameters including DVA, NVA, CS, and RS showed statistically significant improvement. While 89% of the eyes showed improvement in CS, 78%, 71%, and 65% of the eyes showed improvement in NVA, RS, and DVA, respectively. Thus, CS was the most treatment responsive visual parameter.


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