scholarly journals Bladder exstrophy-epispadias complex and the role of methylenetetrahydrofolate reductase C677T polymorphism: A case control study

2016 ◽  
Vol 21 (1) ◽  
pp. 28
Author(s):  
Minu Bajpai ◽  
VenkatShankar Raman ◽  
Abid Ali
Keyword(s):  
Methylenetetrahydrofolate Reductase ◽  
Case Control Study ◽  
Bladder Exstrophy ◽  
Case Control ◽  
C677t Polymorphism ◽  
Control Study

scholarly journals Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk of Colorectal Cancer in the Macedonian Population

2008 ◽  
Vol 11 (2) ◽  
pp. 17-24 ◽  
Author(s):  
N Matevska ◽  
T Josifovski ◽  
A Kapedanovska ◽  
Z Sterjev ◽  
Z Serafimoska ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Methylenetetrahydrofolate Reductase ◽  
Case Control Study ◽  
Age Of Onset ◽  
Case Control ◽  
Mthfr Gene ◽  
Inverse Association ◽  
C677t Polymorphism ◽  
677T Allele ◽  
Control Study

Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk of Colorectal Cancer in the Macedonian PopulationMethylenetetrahydrofolate reductase (MTHFR) regulates the flow of folate groups between DNA synthesis and DNA methylation. A common C677T substitution (Ala222Val) in exon 4 of the MTHFR gene has been linked with the risk of colorectal cancer (CRC). To assess this risk in the Macedonian population, we conducted a case-control study of 413 randomly selected CRC patients and 185 controls without a clinical diagnosis of CRC. We found a statistically significant inverse association between the MTHFR T allele (35.35% for the patients and 41.35% for the controls) and the CRC risk [odds ratio (OR) 0.776; 95% confidence interval (95% CI) 0.603-0.997;p= 0.047). The prevalence of the MTHFR T allele is lower in patients with advanced CRC (Duke' s stage C and D) and with microsatellite instable tumors (MSI+), indicating the inverse association with the CRC aggressiveness and MSI status. This effect seems to be independent of gender, age of onset and localization. We concluded that the MTHFR 677T allele is more likely to have a protective effect on CRC development and progression in the Macedonian population.

The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: The Croatian case–control study

2007 ◽  
Vol 40 (13-14) ◽  
pp. 981-985 ◽  
Author(s):  
Ante Reljic ◽  
Ana-Maria Simundic ◽  
Elizabeta Topic ◽  
Nora Nikolac ◽  
Danijel Justinic ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Methylenetetrahydrofolate Reductase ◽  
Case Control Study ◽  
Mthfr C677t ◽  
Case Control ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism ◽  
Control Study

Methylenetetrahydrofolate Reductase (MTHFЮ Gene Polymorphism (677CT) and Increased Susceptibility to Migraine in Egyptian Population: A Case-Control Study

2019 ◽  
Vol 87 (12) ◽  
pp. 4165-4173
Author(s):  
DOAA M.A. ELZOGHBY, M.D.; MONA M. OSMAN, M.D. ◽  
RANDA M. AMIN, M.D.; HEBA H. ALY, M.D. ◽  
NEHAL E. MAHMOUD, M.D.; DALIA M. ELFAWY, M.D. ◽  
SOMIA ABDELHAMID BAWADY, M.Sc.
Keyword(s):  
Gene Polymorphism ◽  
Methylenetetrahydrofolate Reductase ◽  
Case Control Study ◽  
Case Control ◽  
Egyptian Population ◽  
Control Study ◽  
Increased Susceptibility

scholarly journals P2-233: The role of hippocampal atrophy for the differentiation between MCI subtypes: Results of a case-control study

2012 ◽  
Vol 8 (4S_Part_9) ◽  
pp. P341-P341
Author(s):  
Martha Dlugaj ◽  
Christoph Mönninghoff ◽  
Hans-Jürgen Huppertz ◽  
Isabel Wanke ◽  
Daniel Jokisch ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Hippocampal Atrophy ◽  
Control Study
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