Methylenetetrahydrofolate reductase C677T polymorphism, hypertension and risk of stroke: a prospective, nested case-control study

2016 ◽  
Vol 127 (3) ◽  
pp. 253-260 ◽  
Author(s):  
Shanqun Jiang ◽  
Jianping Li ◽  
Yan Zhang ◽  
Scott A. Venners ◽  
Genfu Tang ◽  
...  
Keyword(s):  
Methylenetetrahydrofolate Reductase ◽  
Case Control Study ◽  
Case Control ◽  
C677t Polymorphism ◽  
Nested Case Control ◽  
Control Study

Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis

2007 ◽  
Vol 106 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Debora Macis ◽  
Patrick Maisonneuve ◽  
Harriet Johansson ◽  
Bernardo Bonanni ◽  
Edoardo Botteri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Methylenetetrahydrofolate Reductase ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk of Colorectal Cancer in the Macedonian Population

2008 ◽  
Vol 11 (2) ◽  
pp. 17-24 ◽  
Author(s):  
N Matevska ◽  
T Josifovski ◽  
A Kapedanovska ◽  
Z Sterjev ◽  
Z Serafimoska ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Methylenetetrahydrofolate Reductase ◽  
Case Control Study ◽  
Age Of Onset ◽  
Case Control ◽  
Mthfr Gene ◽  
Inverse Association ◽  
C677t Polymorphism ◽  
677T Allele ◽  
Control Study

Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk of Colorectal Cancer in the Macedonian PopulationMethylenetetrahydrofolate reductase (MTHFR) regulates the flow of folate groups between DNA synthesis and DNA methylation. A common C677T substitution (Ala222Val) in exon 4 of the MTHFR gene has been linked with the risk of colorectal cancer (CRC). To assess this risk in the Macedonian population, we conducted a case-control study of 413 randomly selected CRC patients and 185 controls without a clinical diagnosis of CRC. We found a statistically significant inverse association between the MTHFR T allele (35.35% for the patients and 41.35% for the controls) and the CRC risk [odds ratio (OR) 0.776; 95% confidence interval (95% CI) 0.603-0.997;p= 0.047). The prevalence of the MTHFR T allele is lower in patients with advanced CRC (Duke' s stage C and D) and with microsatellite instable tumors (MSI+), indicating the inverse association with the CRC aggressiveness and MSI status. This effect seems to be independent of gender, age of onset and localization. We concluded that the MTHFR 677T allele is more likely to have a protective effect on CRC development and progression in the Macedonian population.

Polymorphisms of methylenetetrahydrofolate reductase and the risk of prostate cancer: a nested case–control study

2006 ◽  
Vol 15 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Bethany R. Van Guelpen ◽  
Sara M. Wirén ◽  
Anders R.J. Bergh ◽  
Göran Hallmans ◽  
Pär E. Stattin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Methylenetetrahydrofolate Reductase ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: The Croatian case–control study

2007 ◽  
Vol 40 (13-14) ◽  
pp. 981-985 ◽  
Author(s):  
Ante Reljic ◽  
Ana-Maria Simundic ◽  
Elizabeta Topic ◽  
Nora Nikolac ◽  
Danijel Justinic ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Methylenetetrahydrofolate Reductase ◽  
Case Control Study ◽  
Mthfr C677t ◽  
Case Control ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism ◽  
Control Study
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