Inflammatory myofibroblastic tumor of the urinary bladder diagnosed by anaplastic lymphoma kinase immunostaining

Abstract Background: The inflammatory myofibroblastic tumor (IMT) of urinary bladder is very rare, this case and often misdiagnosed as bladder cancer. We report a patient with atypical clinical features with dysuria and lower abdominal pain. Case presentation: A 32-year-old man presented with dysuria and lower abdominal pain. Computed tomography (CT) demonstrated that a solitary non-papillary tumor was located at the wall of the bladder dome. Partial cystectomy was successfully managed. Immunohistochemically, positivity of the tumor cells for anaplastic lymphoma kinase (ALK), Actin (SM), vimentin, cytokine (CK), epithelial membrane antigen (EMA) and Ki-67. Based on the the above clinical features、histopathology and immunohistochemical, the tumor was definitively diagnosed as bladder’s IMT. After 24 months, there was no signs of recurrence and metastasis with CT and cystoscopy.Conclusion: A rare case of inflammatory myofibroblastic tumor of urinary bladder after partial cystectomy was reported. It is essential for urologists and scientists to entirely understand the characteristics of the inflammatory myofibroblastic tumor and make a better clinical guideline, to avoid over treatments.

Download Full-text

Intracranial Inflammatory Myofibroblastic Tumor with Negative Expression of Anaplastic Lymphoma Kinase: A Case Report and Review of the Literature

World Neurosurgery ◽

10.1016/j.wneu.2019.01.155 ◽

2019 ◽

Vol 125 ◽

pp. 117-122 ◽

Cited By ~ 1

Author(s):

Xiaoke Wang ◽

Yang Chen ◽

Xiujuan Wu ◽

Hongliang Zhang

Keyword(s):

Case Report ◽

Anaplastic Lymphoma Kinase ◽

Inflammatory Myofibroblastic Tumor ◽

Review Of The Literature ◽

Anaplastic Lymphoma ◽

Kinase A

Download Full-text

How long should we continue crizotinib in ALK translocation-positive inflammatory myofibroblastic tumors? Long-term complete response with crizotinib and review of the literature

Journal of Oncology Pharmacy Practice ◽

10.1177/1078155219879757 ◽

2019 ◽

Vol 26 (4) ◽

pp. 1011-1018 ◽

Cited By ~ 4

Author(s):

Ozkan Alan ◽

Okan Kuzhan ◽

Sinan Koca ◽

Tugba Akin Telli ◽

Tugba Basoglu ◽

...

Keyword(s):

Anaplastic Lymphoma Kinase ◽

Inflammatory Myofibroblastic Tumor ◽

Kinase Inhibitor ◽

Case Reports ◽

Tumor Control ◽

Anaplastic Lymphoma Kinase Inhibitor ◽

Anaplastic Lymphoma ◽

Short Period ◽

Inflammatory Myofibroblastic Tumors

Introduction Inflammatory myofibroblastic tumor is a rare disease which is typically seen in children and young adults. Approximately half of the inflammatory myofibroblastic tumors contain translocations that result in over-expression of anaplastic lymphoma kinase gene. Herein, we present two anaplastic lymphoma kinase-positive cases with long-term remission with crizotinib. We do not know how long these therapies need to be continued. Case reports We present two cases of inflammatory myofibroblastic tumor treated with anaplastic lymphoma kinase inhibitor therapies: an 8-year-old Turkish boy and a 21-year-old Caucasian man. Management and outcome Two cases, both with good tumor control under crizotinib, but one who progressed on drug holiday, responded again to the same drug, and had a very short period of response after restarting crizotinib. Conclusion A molecular-targeted drug (anaplastic lymphoma kinase inhibitor) was found to be extremely effective as selective therapy for inflammatory myofibroblastic tumor with anaplastic lymphoma kinase translocation. Here, we want to emphasize the continuation of this treatment after achieving a good response until progression or a major side effect.

Download Full-text

Anaplastic Lymphoma Kinase‐Positive Inflammatory Myofibroblastic Tumor Mimicking Meningioma: A Case Report

Neurographics ◽

10.3174/ng.2000037 ◽

2021 ◽

Vol 11 (2) ◽

pp. 75-79

Author(s):

J.B. Stone ◽

R. Stonebridge ◽

R.D. Bhuta ◽

J.L. Boxerman

Keyword(s):

Anaplastic Lymphoma Kinase ◽

Inflammatory Myofibroblastic Tumor ◽

Malignant Degeneration ◽

En Bloc ◽

Anaplastic Lymphoma ◽

Intracranial Involvement ◽

Activating Mutation ◽

Positive Immunostaining ◽

Children And Young Adults ◽

Fibrous Tumor

A 15-year-old girl presented with intermittent nausea and vomiting, headache, and vision changes. MR imaging of the brain revealed an avidly enhancing infratemporal dural-based mass arising from the tentorium, with hyperintensity on T2WI and transdural extension into the posterior cranial fossa. The well-encapsulated fibrous tumor was resected en bloc after cauterization of its rich tentorial arterial supply. Histologic examination demonstrated pleomorphic myofibroblastic cells admixed with an inflammatory infiltrate. Spindle cells showed strong, diffusely positive immunostaining for anaplastic lymphoma kinase, and genomic sequencing uncovered a tropomyosin 3 gene and anaplastic lymphoma kinase fusion and an activating mutation in the Kirsten rat sarcoma oncogene. A diagnosis of inflammatory myofibroblastic tumor was made. Primary intracranial involvement of inflammatory myofibroblastic tumor is exceptionally rare, and few cases that feature an anaplastic lymphoma kinase translocation have been described. Inflammatory myofibroblastic tumor‐CNS is an important differential diagnosis for dural-based lesions in children and young adults due to its propensity for recurrence and malignant degeneration.

Download Full-text