Differences in traditional and non-traditional risk factors with special reference to nutritional factors in patients with coronary artery disease with or without diabetes mellitus

Background It is still unknown whether traditional risk factors may have a sex‐specific impact on coronary artery disease (CAD) burden. Methods and Results We identified 14 793 patients who underwent coronary angiography for acute coronary syndromes in the ISACS‐TC (International Survey of Acute Coronary Syndromes in Transitional Countries; ClinicalTrials.gov , NCT01218776) registry from 2010 to 2019. The main outcome measure was the association between traditional risk factors and severity of CAD and its relationship with 30‐day mortality. Relative risk (RR) ratios and 95% CIs were calculated from the ratio of the absolute risks of women versus men using inverse probability of weighting. Estimates were compared by test of interaction on the log scale. Severity of CAD was categorized as obstructive (≥50% stenosis) versus nonobstructive CAD. The RR ratio for obstructive CAD in women versus men among people without diabetes mellitus was 0.49 (95% CI, 0.41–0.60) and among those with diabetes mellitus was 0.89 (95% CI, 0.62–1.29), with an interaction by diabetes mellitus status of P =0.002. Exposure to smoking shifted the RR ratios from 0.50 (95% CI, 0.41–0.61) in nonsmokers to 0.75 (95% CI, 0.54–1.03) in current smokers, with an interaction by smoking status of P =0.018. There were no significant sex‐related interactions with hypercholesterolemia and hypertension. Women with obstructive CAD had higher 30‐day mortality rates than men (RR, 1.75; 95% CI, 1.48–2.07). No sex differences in mortality were observed in patients with nonobstructive CAD. Conclusions Obstructive CAD in women signifies a higher risk for mortality compared with men. Current smoking and diabetes mellitus disproportionally increase the risk of obstructive CAD in women. Achieving the goal of improving cardiovascular health in women still requires intensive efforts toward further implementation of lifestyle and treatment interventions. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01218776.

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Effect of Number of Achieved Targets for Risk Factors on Coronary Artery Disease (CAD) in Those With and Without Diabetes Mellitus (DM)

Diabetes ◽

10.2337/db18-442-p ◽

2018 ◽

Vol 67 (Supplement 1) ◽

pp. 442-P

Author(s):

KAZUYA FUJIHARA ◽

YASUHIRO MATSUBAYASHI ◽

MASARU KITAZAWA ◽

MASAHIKO YAMAMOTO ◽

TAEKO OSAWA ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Artery Disease

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Prevalence of peripheral arterial disease in type 2 diabetes mellitus and it’s correlation with coronary artery disease and it’s risk factors

Indian Heart Journal ◽

10.1016/j.ihj.2018.11.008 ◽

2018 ◽

Vol 70 ◽

pp. S45-S46

Author(s):

Bharat Kumar Goud C

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Type 2 Diabetes Mellitus ◽

Coronary Artery ◽

Arterial Disease ◽

Artery Disease ◽

Peripheral Arterial

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Limited utilities of N-terminal pro B-type natriuretic peptide and other newer risk markers compared with traditional risk factors for prediction of significant angiographic lesions in stable coronary artery disease

Heart ◽

10.1136/hrt.2008.145425 ◽

2008 ◽

Vol 95 (4) ◽

pp. 297-303 ◽

Cited By ~ 17

Author(s):

A Peer ◽

G Falkensammer ◽

H Alber ◽

A Kroiss ◽

A Griesmacher ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Natriuretic Peptide ◽

Stable Coronary Artery Disease ◽

Risk Markers ◽

Traditional Risk Factors ◽

Artery Disease

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W09.266 Relation between insulin resistance and traditional risk factors for coronary artery disease in obese type 2 diabetics

Atherosclerosis Supplements ◽

10.1016/s1567-5688(04)90265-1 ◽

2004 ◽

Vol 5 (1) ◽

pp. 62

Author(s):

M. Zamaklar ◽

K. Lalic ◽

N. Rajkovic ◽

D. Trifunovic ◽

L. Popovic

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Type 2 Diabetics ◽

Traditional Risk Factors ◽

Artery Disease

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Traditional risk factors as determinants of heart rate recovery in patients with diabetes mellitus type 2 without known coronary artery disease

IOP Conference Series Earth and Environmental Science ◽

10.1088/1755-1315/130/1/012040 ◽

2018 ◽

Vol 130 ◽

pp. 012040

Author(s):

Sanny Silaban ◽

A Afif Siregar ◽

H Hasan ◽

C Aryfa Andra

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Coronary Artery Disease ◽

Heart Rate ◽

Diabetes Mellitus Type 2 ◽

Heart Rate Recovery ◽

Patients With Diabetes ◽

Traditional Risk Factors ◽

Artery Disease

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Diabetes mellitus and other cardiovascular risk factors in lower-extremity peripheral artery disease versus coronary artery disease: an analysis of 1,121,359 cases from the nationwide databases

Cardiovascular Diabetology ◽

10.1186/s12933-019-0955-5 ◽

2019 ◽

Vol 18 (1) ◽

Cited By ~ 9

Author(s):

Mitsuyoshi Takahara ◽

◽

Osamu Iida ◽

Shun Kohsaka ◽

Yoshimitsu Soga ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Coronary Artery Disease ◽

Cardiovascular Risk ◽

Coronary Artery ◽

Lower Extremity ◽

Cardiovascular Risk Factors ◽

Clinical Profile ◽

Peripheral Artery ◽

Artery Disease

Abstract Background Lower-extremity peripheral artery disease (LE-PAD) and coronary artery disease (CAD) are both pathologically rooted in atherosclerosis, and their shared clinical features regarding the exposure to cardiovascular risk factors have been emphasized. However, comparative data of the two cardiovascular diseases (CVDs) were so far lacking. The purpose of this study was to directly compare the clinical profile between cases undergoing endovascular therapy (EVT) for LE-PAD and those undergoing percutaneous coronary intervention (PCI). Methods Data were extracted from the nationwide procedural databases of EVT and PCI in Japan (J-EVT and J-PCI) between 2012 and 2017. A total of 1,121,359 cases (103,887 EVT cases for critical limb ischemia [CLI] or intermittent claudication and 1,017,472 PCI cases for acute coronary syndrome [ACS] or stable angina) were analyzed. Heterogeneity in clinical profile between CVDs was evaluated using the C statistic of the logistic regression model for which dependent variable was one CVD versus another, and explanatory variables were clinical profile. When two CVDs were completely discriminated from each other by the developed model, the C statistic (discrimination ability) of the model would be equal to 1, indicating that the two CVDs were completely different in clinical profile. On the other hand, when two CVDs were identical in clinical profile, the developed model would not discriminate them at all, with the C statistic equal to 0.5. Results Mean age was 73.5 ± 9.3 years in LE-PAD patients versus 70.0 ± 11.2 years in CAD patients (P < 0.001). The prevalence of diabetes mellitus and end-stage renal disease was 1.96- and 6.39-times higher in LE-PAD patients than in CAD patients (both P < 0.001). The higher prevalence was observed irrespective of age group. The exposure to other cardiovascular risk factors and the likelihood of cardiovascular risk clustering also varied between the diseases. The between-disease heterogeneity in patient profile was particularly evident between CLI and ACS, with the C statistic equal to 0.833 (95% CI 0.831–0.836). Conclusions The current study, an analysis based on nationwide procedural databases, confirmed that patient profiles were not identical but rather considerably different between clinically significant LE-PAD and CAD warranting revascularization.

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