Evaluation of platelet indices as additional diagnostic tool for neonatal sepsis

Astrocyte ◽  
2018 ◽  
Vol 4 (4) ◽  
pp. 205
Author(s):  
Sugandha Arya ◽  
Aliza Mittal ◽  
LaxmanS Charan ◽  
Sumita Saluja ◽  
Harish Chellani
Keyword(s):  
Diagnostic Tool ◽  
Neonatal Sepsis ◽  
Platelet Indices

scholarly journals Correlation of platelet count and platelet indices with neonatal sepsis-diagnostic and prognostic indicator

2017 ◽  
Vol 4 (8) ◽  
pp. 511-518
Author(s):  
Dr. Dilipkumar Choudhary ◽  
◽  
Dr. Ajay Kumar Tiwari ◽  
Dr.Subhash Narang ◽  
Dr. Jatin Chhabra ◽  
...  
Keyword(s):  
Platelet Count ◽  
Neonatal Sepsis ◽  
Prognostic Indicator ◽  
Platelet Indices

A Study of Platelet Count and Platelet Indices in Neonatal Sepsis

2017 ◽  
Vol 6 (3 (part-1)) ◽  
pp. 523-526
Author(s):  
Majumder Ankur ◽  
◽  
P Shashikala ◽  
Nandyal Sonam S. ◽  
Gowda Kavita U. ◽  
...  
Keyword(s):  
Platelet Count ◽  
Neonatal Sepsis ◽  
Platelet Indices

scholarly journals Procalcitonin as a diagnostic tool for bacterial neonatal sepsis

2015 ◽  
Vol 55 (5) ◽  
pp. 268
Author(s):  
Nely Nelly ◽  
Guslihan Dasa Tjipta ◽  
Hakimi Hakimi ◽  
Bugis Mardina Lubis
Keyword(s):  
Blood Culture ◽  
Diagnostic Tool ◽  
Neonatal Sepsis ◽  
Predictive Value ◽  
Gold Standard ◽  
Diagnostic Study ◽  
Bacterial Sepsis ◽  
Quick Method ◽  
Reactive Protein ◽  
Early Diagnostic

Background Bacterial sepsis is the main cause of morbidity and mortality in neonates. Early diagnosis and appropriate treatment can reduce the mortality rate. Blood culture is the gold standard for diagnosis of bacterial sepsis, but it requires 3-5 days for results. Since the disease may progress rapidly in neonates, a faster diagnostic test is needed. Measurement of procalcitonin levels may be a quick method to diagnose bacterial sepsis in neonates. Some studies found the sensitivity of procalcitonin to be between 92-100%. Objective To assess the use of procalcitonin as an early diagnostic tool for bacterial neonatal sepsis. Methods This diagnostic study was conducted from October 2011 to February 2012. Forty-three neonates in the Perinatology Unit at H. Adam Malik Hospital were suspected to have bacterial sepsis. They underwent routine blood counts, blood cultures, as well as C-reactive protein and procalcitonin measurements. Subjects were collected by consecutive sampling. The gold standard of sepsis was based on any microorganism found in blood culture. Results Of 43 neonates, 36 neonates had bacterial sepsis. We found that procalcitonin sensitivity was 100%, specificity 85.71%, positive predictive value 97.29% and negative predictive value 100%. The ROC curve showed a cut-off point of 0.929 (95%CI 0.713 to 0.953). Conclusion Procalcitonin is useful as an early diagnostic tool for bacterial neonatal sepsis.

scholarly journals Interleukin-6 as a Diagnostic Tool in Neonatal Sepsis

2011 ◽  
Vol 70 ◽  
pp. 492-492
Author(s):  
A Sow ◽  
J -M Jellimann ◽  
P Franck ◽  
J -M Hascoet ◽  
R Vieux
Keyword(s):  
Diagnostic Tool ◽  
Interleukin 6 ◽  
Neonatal Sepsis

scholarly journals Evaluation of platelet and its indices as a marker of neonatal sepsis: a prospective case control study

2018 ◽  
Vol 5 (5) ◽  
pp. 1898 ◽  
Author(s):  
Ratana Ram Choudhary ◽  
Mohan Makwana ◽  
Harish Kumar Mourya ◽  
Jagdish Dabi ◽  
Kartika Gulati
Keyword(s):  
Platelet Count ◽  
Blood Culture ◽  
Neonatal Sepsis ◽  
Neonatal Morbidity ◽  
Signs And Symptoms ◽  
Control Group ◽  
Case Group ◽  
Platelet Indices ◽  
Sepsis Screen ◽  
Sepsis Screening

Background: Neonatal sepsis is major cause of neonatal morbidity and mortality worldwide. Blood culture and sepsis screening are currently used method, but their utility is limited due to delayed reporting and increased cost. Platelet indices are one such set of parameters which can be helpful in the future diagnosis of neonatal sepsis. This study was aimed to evaluate the significance of platelet indices either alone or in combination with existing sepsis screen as a marker of neonatal sepsis.Methods: Neonates admitted in the neonatal unit of Hospital and showing signs and symptoms of sepsis, and/or born to mothers with risk factor for sepsis were included in this study. Investigations sent for all these neonates included blood culture, sepsis screen (CRP, micro ESR, TLC, ANC, IT ratio) and platelet indices (Platelet count, MPV, PDW).Results: In present study, 81.12% neonates in case group had platelet count less than 1.5lacs/mm3 while in control group 20.91% neonates only had the same. This difference was statistically significant, (p<0.0001). Similarly, 70.91% neonates in case group had MPV more than >10.8 fl whereas in control group only 26.53% neonates had the same, with difference was statistically significant, (p<0.0001) Similarly, 65.81% neonates in case group and 34.69% in control group had PDW more than 19.1fl and this difference was statistically significant, (p=0.0001).Conclusions: High PDW, high MPV and low platelet count are more associated with neonatal sepsis. So, platelet and its indices may be used as a sensitive marker to identify septic babies and it may be combined with existing sepsis screen to specifically exclude non-septic case.

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