Formulation and evaluation of mucoadhesive tablets of furosemide by design of experiment

The present investigation focuses on the development of mucoadhesive tablets of captopril which are designed to prolong the gastric residence time after oral administration. Matrix tablets of captopril were formulated using four mucoadhesive polymers namely guar gum, xanthan gum, HPMC K4M and HPMC K15M and studied for parameters such as weight variation, thickness, hardness, content uniformity, swelling index, mucoadhesive force and in vitro drug release. Tablets formulated Xanthan gum or HPMC K4M with HPMC K15M provide slow release of captopril over period of 12 hr and were found suitable for maintenance portion of oral controlled release tablets. The cumulative % of drug release of formulation F9 and F10 were 90 and 92, respectively. In vitro release from these tablets was diffusion controlled and followed zero order kinetics. The ‘n’ values obtained from the pappas-karsemeyer equation suggested that all the formulation showed drug release by non-fickian diffusion mechanism. Tablets formulated Xanthan gum or HPMC K4M with HPMC K15M (1:1) were established to be the optimum formulation with optimum bioadhesive force, swelling index & desired invitro drug release. This product was further subjected to stability study, the results of which indicated no significant change with respect to Adhesive strength and in vitro drug release study.

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A Design of Experiment Approach to the Synthesis of Alendronate-incorporated Hydroxyapatite

Revista de Chimie ◽

10.37358/rc.18.8.6451 ◽

2018 ◽

Vol 69 (8) ◽

pp. 1944-1948 ◽

Cited By ~ 1

Author(s):

Adina Turcu Stiolica ◽

Maria Viorica Bubulica ◽

Oana Elena Nicolaescu ◽

Octavian Croitoru ◽

Mariana Popescu ◽

...

Keyword(s):

Process Parameters ◽

Design Of Experiment ◽

Calcium Nitrate ◽

Chemical Precipitation ◽

Synthesis Temperature ◽

Ripening Time ◽

Synthesis Design ◽

N2 Atmosphere ◽

Addition Rate ◽

Incorporation Efficiency

A design of experiment (DoE) approach is presented for the optimization of Alendronate-hydroxyapatite nanoparticles� synthesis. The synthesis was performed using the chemical precipitation technique from calcium nitrate, diammonium hydrogen phosphate and alendronate. Synthesis temperature, reactant addition rate and ripening time were chosen as the most relevant experimental factors for our synthesis. Design of Experiments was used in order to measure these conclusive process parameters and their effect on controlling some final nanoparticles parameters, such us: alendronate incorporation efficiency (IncorporationEfficiency, %), hydroxyapatite crystallite size (Size_XRD, nm), hydroxyapatite particle size distribution (Size_DLS, �). Our study found that better HA-AL incorporation efficiency and small nonoparticles can be obtained using the following chemical process parameters: reaction temperature 30oC or smaller, ripening time 108h and addition rate 0.1mol/min. The analysis of more than one nanoparticles characteristics was possible using DoE software, MODDE 9.1. Thus, hydroxyapatite-alendronate incorporation efficiency should be expected to increase with decreasing temperature below 300C, increasing the maturate time at least 108h, at an addition rate of 0.1mol/min, in an N2 atmosphere. The same conditions will ensure nanoparticles small size that would be more desirable for the application of implants.

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Design of experiment

Bioprocess Engineering ◽

10.1016/b978-0-12-821012-3.00020-8 ◽

2020 ◽

pp. 885-933

Author(s):

Shijie Liu

Keyword(s):

Design Of Experiment

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A design of experiment approach as applied to the analysis of diffuser-augmented wind turbines

Energy Conversion and Management ◽

10.1016/j.enconman.2021.113924 ◽

2021 ◽

Vol 235 ◽

pp. 113924

Author(s):

R. Bontempo ◽

R. Carandente ◽

M. Manna

Keyword(s):

Wind Turbines ◽

Design Of Experiment

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Design of experiment rational optimization of an inkjet deposition of silver on Kapton

IEEE Sensors Journal ◽

10.1109/jsen.2021.3058543 ◽

2021 ◽

pp. 1-1

Author(s):

Alessio Bucciarelli ◽

Emanuale Olivetti ◽

Andrea Adami ◽

Leandro Lorenzelli

Keyword(s):

Design Of Experiment

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Achieving selectivity in porphyrin bromination through a DoE-driven optimization under continuous flow conditions

Journal of Flow Chemistry ◽

10.1007/s41981-020-00131-4 ◽

2020 ◽

Author(s):

Paolo Zardi ◽

Michele Maggini ◽

Tommaso Carofiglio

Keyword(s):

Reaction Time ◽

Design Of Experiment ◽

Continuous Flow ◽

Optimization Process ◽

Porphyrin Ring ◽

Flow Conditions ◽

Reaction Parameters ◽

Synthetic Procedure ◽

Relevant Factors ◽

Post Functionalization

AbstractThe post-functionalization of porphyrins through the bromination in β position of the pyrrolic rings is a relevant transformation because the resulting bromoderivatives are useful synthons to covalently link a variety of chemical architectures to a porphyrin ring. However, single bromination of porphyrins is a challenging reaction for the abundancy of reactive β-pyrrolic positions in the aromatic macrocycle. We herein report a synthetic procedure for the efficient preparation of 2-bromo-5,10,15,20-tetraphenylporphyrin (1) under continuous flow conditions. The use of flow technology allows to reach an accurate control over critical reaction parameters such as temperature and reaction time. Furthermore, by performing the optimization process through a statistical DoE (Design of Experiment) approach, these parameters could be properly adjusted with a limited number of experiments. This process led us to a better understanding of the relevant factors that govern porphyrins monobromination and to obtain compound 1 with an unprecedent 80% yield.

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