Comparative analysis of BIOCHIP mosaic-based indirect immunofluorescence with direct immunofluorescence in diagnosis of autoimmune bullous diseases: A cross-sectional study

Background and objectives: Diffuse idiopathic skeletal hyperostosis (DISH) is a bone formation disease in which only skeletal signs are considered in classification criteria. The aim of the study was to describe different phenotypes in DISH patients based on clinicoradiological features. Materials and Methods: We evaluated 97 patients who met the Resnick or modified Utsinger classification criteria for DISH and were diagnosed at our hospital from 2004 to 2015. Patients were stratified into: (a) peripheral pattern (PP)—Resnick criteria not met but presenting ≥3 peripheral enthesopathies; (b) axial pattern (AP)—Resnick criteria met but <3 enthesopathies; and (c) mixed pattern (MP)—Resnick criteria met with ≥3 enthesopathies. Statistical analysis was carried out to identify variables that might predict classification in a given group. Results: Fifty-six of the 97 patients included (57.7%) were male and 72.2% fulfilled the Resnick criteria. Applying our classification, 39.7% were stratified as MP, 30.9% as AP and 29.4% as PP. Clinical enthesopathy was reported in 40.2% of patients during the course of the disease. Sixty-eight patients were included in a comparative analysis of variables between DISH patterns. The results showed a predominance of women (p < 0.004), early onset (p < 0.03), hip involvement (p < 0.003) and enthesitis (p < 0.001) as hallmarks of PP. Asymptomatic patients were most frequently observed in AP (28.6%, MP 3.8%, PP 5.0%) while MP was characterized by a more extensive disease. Conclusions: We believe DISH has distinct phenotypes and describe a PP phenotype that is not usually considered. Extravertebral manifestations should be included in the new classification criteria in order to cover the entire spectrum of the disease.

Download Full-text

Utility of direct immunofluorescence in the diagnosis of small vessel vasculitis of the skin: A cross-sectional study

Indian Dermatology Online Journal ◽

10.4103/idoj.idoj_298_16 ◽

2017 ◽

Vol 8 (6) ◽

pp. 515 ◽

Cited By ~ 4

Author(s):

M Poornimambaa ◽

N Asokan ◽

Joy Augustine

Keyword(s):

Cross Sectional Study ◽

Small Vessel ◽

Small Vessel Vasculitis ◽

Direct Immunofluorescence ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Comparative analysis of serum lipid profiles in patients with and without gallstones: A prospective cross-sectional study

Annals of Medicine and Surgery ◽

10.1016/j.amsu.2019.04.003 ◽

2019 ◽

Vol 42 ◽

pp. 11-13

Author(s):

Sikandar Hayat ◽

Zarbakht Hassan ◽

Shabbar Hussain Changazi ◽

Anam Zahra ◽

Muhammad Noman ◽

...

Keyword(s):

Comparative Analysis ◽

Serum Lipid ◽

Cross Sectional Study ◽

Lipid Profiles ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Comparative Analysis of Adverse Drug Reactions between Interferon Alpha 2B and Sofosbuvir in the Treatment of Hepatits C at GIMHS, Sindh, Pakistan

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i29b31607 ◽

2021 ◽

pp. 211-218

Author(s):

Sajid Ali ◽

Marvi Metlo ◽

Zuheeb Ahmed ◽

Tahseen Ahmed ◽

Arslan Ahmer ◽

...

Keyword(s):

Comparative Analysis ◽

Adverse Drug Reactions ◽

Random Sampling ◽

Cross Sectional Study ◽

Male Gender ◽

Sectional Study ◽

Drug Reactions ◽

Cross Sectional ◽

Interferon Alpha 2B ◽

Loss Of Appetite

A descriptive cross-sectional study was conducted on 300 patients selected by random sampling who were reported with Hepatitis-C at GIMHS. Questions were asked from patients regarding symptoms and adverse drug reactions (ADR’S). Results were analyzed by using SPSS-22. Out of total patients (n=300) the frequency of male gender was (n=192) as compared to females (n=108). Among 300 patients some patients were on sofosbuvir (n=150), patients on interferon (n=150). Rate of ADR’S observed with interferon as fever (n=28), anemia (n=27), hair loss (n=21), headache (n=19), insomnia (n= 11), nausea (n=13), depression (n=14, 09), malaise (n=25), vomiting (n=06), ulcer (n=13), pain and redness at site of injection (n=17). While rate of ADR’S in patients who were on sofosbuvir, fever (n=33), chill (n=17), nausea (n=28), anemia (n=06), headache (n=14), insomnia (n=13), loss of appetite (n=5), diarrhea (n=1). This study concluded that as compared to Interferon, rate of ADR’S were less with Sofosbuvir.

Download Full-text