scholarly journals Pancytokeratin immunostained tumor buds and cytoplasmic pseudofragments are reliable early predictive variables for regional lymph node metastatic risk assessment of oral squamous cell carcinoma

2020 ◽  
Vol 31 (6) ◽  
pp. 904
Author(s):  
SV Sowmya ◽  
RoopaS Rao ◽  
Kavitha Prasad
2020 ◽  
Vol 16 (2) ◽  
pp. 71-73
Author(s):  
Rajina Sahi ◽  
Dilip Karmacharya ◽  
Thungathurthi Sheshagiri Rao

Background: Squamous cell carcinoma of oral cavity has become one of the most common malignancies in Nepal. Neck node involvement is frequently seen in this type of malignancy. Depth of invasion is one of the most important criteria for determining further management of the patient. This study is undertaken to see whether the depth of tumor invasion is a reliable parameter for predicting regional lymph node metastasis. Methods: This retrospective study was done among 85 patients of pathology department of   the College of Medical Sciences Teaching Hospital, Bharatpur from May to Oct 2019.   Results: This study found that most of the cases of oral squamous cell carcinoma had occurred in old age within 60-70 years of age. The most common site of occurrence for oral squamous cell carcinoma was tongue (60%), followed by lower alveolus (20%).  The depth of invasion of 5mm and more was among 89% of the cases while cervical lymph node metastasis was among 53% cases. Most of the cases (60%) were well-differentiated (Grade I). There was no statistical relationship between depth of invasion and lymph node metastasis (p>0.05). Conclusions: The most common site of oral squamous cell carcinoma was tongue. Depth of invasion was not a predictor for lymph node metastasis. Keywords: depth of invasion;  lymph node metastasis; oral squamous cell carcinoma; simple compass divider.


2013 ◽  
Vol 1 (2) ◽  
pp. 02-06
Author(s):  
SM Anwar Sadat ◽  
Sufia Nasrin Rita ◽  
Shoma Banik ◽  
Md Nazmul Hasan Khandker ◽  
Md Mahfuz Hossain ◽  
...  

A cross sectional study of 29 cases of oral squamous cell carcinoma with or without  cervical lymph node metastasis was done among Bangladeshi patients from January 2006 to December 2007. Majority of the study subjects (34.5%) belonged to the age group of 40-49 years. 58.6% of the study subjects were male, while remaining 41.4% of them were female. 51.7% of the lesions were located in the alveolar ridge where the other common sites were buccal mucosa (27.6%) and retro molar area (13.8%). Half of the study subjects (51.7%) were habituated to betel quid chewing followed by 37.9% and 10.3% were habituated to smoking and betel quid-smoking respectively. Grade I lesions was most prevalent (75.9%) in the study subjects.  Majority of cases presented with Stage IV lesions (55.2%). The sensitivity, specificity, positive predictive value, negative predictive value & accuracy of clinical palpation method for determining metastatic cervical lymph nodes were 93.33%, 64.29%, 73.68%, 90% and 79.3% respectively. Careful and repeated clinical palpation plays important role in evaluation of cervical lymph nodes though several modern techniques may help additionally in the management of oral cancer.DOI: http://dx.doi.org/10.3329/updcj.v1i2.13978 Update Dent. Coll. j. 2011: 1(2): 02-06


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