Effect of casein phosphopeptide–amorphous calcium phosphate as a remineralizing agent – An In Vivo study

Clinical Relevance Under the conditions of this study, 15% carbamide peroxide with potassium nitrate and fluoride exhibited greater bleaching potential but exhibited no difference in sensitivity compared to 16% carbamide peroxide with amorphous calcium phosphate.

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Real Time In Vivo Confocal Microscopic Analysis of the Enamel Remineralization by Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP): A Clinical Proof-of-Concept Study

Applied Sciences ◽

10.3390/app10124155 ◽

2020 ◽

Vol 10 (12) ◽

pp. 4155

Author(s):

Maria Contaldo ◽

Dario Di Stasio ◽

Fedora della Vella ◽

Dorina Lauritano ◽

Rosario Serpico ◽

...

Keyword(s):

Calcium Phosphate ◽

Amorphous Calcium Phosphate ◽

Laser Scanning ◽

Laser Scanning Microscopy ◽

Confocal Laser Scanning ◽

Confocal Laser ◽

Proof Of Concept ◽

Concept Study ◽

Casein Phosphopeptide

Enamel defects (EDs) are qualitative and/or quantitative disturbances of the dental surface. To date, the responsiveness to remineralizing treatments has been studied ex vivo, on dental sections from extracted teeth. The present research aims to establish if in vivo reflectance confocal laser scanning microscopy is able to visualize the changes in the enamel architecture on living teeth, before, during and after remineralizing treatments by casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). As proof-of-concept study, 17 consecutive children affected by EDs were enrolled and 38 EDs were considered. A CPP-ACP mousse was applied twice a week for 6 weeks and clinical and microscopic images were collected before, during and after the treatment for evaluating the changes occurred. For in vivo microscopic imaging, a reflectance confocal laser scanning microscope (RCM) for in vivo use was adopted. In this study RCM was proven to be able to visualize in vivo and at microscopic resolution the changes occurred during the remineralizing processes without needing for dental extractions and histopathological procedures. This in vivo RCM capability could encourage its clinical application in monitoring responsiveness to enamel therapies.

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Long-term remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo: A systematic review

Journal of Dentistry ◽

10.1016/j.jdent.2014.03.015 ◽

2014 ◽

Vol 42 (7) ◽

pp. 769-777 ◽

Cited By ~ 45

Author(s):

Jialing Li ◽

Xiaoqiu Xie ◽

Yu Wang ◽

Wei Yin ◽

Joseph S. Antoun ◽

...

Keyword(s):

Systematic Review ◽

Calcium Phosphate ◽

Amorphous Calcium Phosphate ◽

Casein Phosphopeptide ◽

Early Caries ◽

Caries Lesions

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Efficacy of casein derivate CPP-ACP1

RGO - Revista Gaúcha de Odontologia ◽

10.1590/1981-8637201400030000032595 ◽

2014 ◽

Vol 62 (3) ◽

pp. 243-252

Author(s):

Renata Faria PEREIRA ◽

Soraya Coelho LEAL

Keyword(s):

Calcium Phosphate ◽

Randomized Controlled Trials ◽

Systematic Reviews ◽

Amorphous Calcium Phosphate ◽

Controlled Trials ◽

Randomized Controlled ◽

Pubmed Database ◽

Casein Phosphopeptide

OBJECTIVE: A literature review of systematic reviews and in situ and in vivo randomized controlled trials was conducted in order to assess the role of casein phosphopeptide - amorphous calcium phosphate in providing caries-preventive effect superior to any intervention or placebo. METHODS: Initially, Pubmed database was searched for systematic reviews. Two systematic reviews were identified, which concluded that the quantity and quality of randomized controlled trials were insufficient to recommend the clinical use of the product. After this, Pubmed database was searched for in situ and in vivo randomized controlled trials that were not included in the reviews identified. In vivo and in situ studies yielded mixed results. RESULTS: In situ studies indicated greater efficacy of casein phosphopeptide - amorphous calcium phosphate in comparison with placebo. Whereas, in vivo studies demonstrated different findings CONCLUSION: Casein phosphopeptide - amorphous calcium phosphate had a performance equivalent to or greater efficacy than placebo; fluoride was more effective than the casein complex; casein phosphopeptide - amorphous calcium phosphate associated with fluoride showed better or equivalent performance to that of placebo. In view of available evidence, it was not possible to generalize the indication of casein phosphopeptide - amorphous calcium phosphate for preventing dental caries. Further studies on the preventive effect and longer treatment applications are recommended.

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