Long-term remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo: A systematic review

Enamel defects (EDs) are qualitative and/or quantitative disturbances of the dental surface. To date, the responsiveness to remineralizing treatments has been studied ex vivo, on dental sections from extracted teeth. The present research aims to establish if in vivo reflectance confocal laser scanning microscopy is able to visualize the changes in the enamel architecture on living teeth, before, during and after remineralizing treatments by casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). As proof-of-concept study, 17 consecutive children affected by EDs were enrolled and 38 EDs were considered. A CPP-ACP mousse was applied twice a week for 6 weeks and clinical and microscopic images were collected before, during and after the treatment for evaluating the changes occurred. For in vivo microscopic imaging, a reflectance confocal laser scanning microscope (RCM) for in vivo use was adopted. In this study RCM was proven to be able to visualize in vivo and at microscopic resolution the changes occurred during the remineralizing processes without needing for dental extractions and histopathological procedures. This in vivo RCM capability could encourage its clinical application in monitoring responsiveness to enamel therapies.

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Effects of casein phosphopeptide-amorphous calcium phosphate application after interproximal stripping on enamel surface: An in-vivo study

American Journal of Orthodontics and Dentofacial Orthopedics ◽

10.1016/j.ajodo.2016.06.033 ◽

2017 ◽

Vol 151 (1) ◽

pp. 167-173 ◽

Cited By ~ 2

Author(s):

Mehmet Bayram ◽

Adem Kusgoz ◽

Cemal Yesilyurt ◽

Metin Nur

Keyword(s):

Calcium Phosphate ◽

Amorphous Calcium Phosphate ◽

Enamel Surface ◽

In Vivo Study ◽

Casein Phosphopeptide

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Comparison of Effect of Fluoride Varnish, Fluoride-releasing Composite, and Casein Phosphopeptide-amorphous Calcium Phosphate Fluoride on Demineralization around Brackets: An in vivo Study

The Journal of Indian Orthodontic Society ◽

10.1177/0974909820140206 ◽

2014 ◽

Vol 48 (2) ◽

pp. 105-110 ◽

Cited By ~ 1

Author(s):

Navya Puvvula ◽

Sudhakar Pathuri ◽

CV Padma Priya ◽

A Sai Prakash

Keyword(s):

Calcium Phosphate ◽

Amorphous Calcium Phosphate ◽

In Vivo Study ◽

Fluoride Varnish ◽

Casein Phosphopeptide

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Comparative Evaluation of Casein Phosphopeptide - Amorphous Calcium Phosphate and Fluoride in Managing Early Caries Lesions

Revista de Chimie ◽

10.37358/rc.19.10.7638 ◽

2019 ◽

Vol 70 (10) ◽

pp. 3746-3749

Author(s):

Livia Bobu ◽

Alice Murariu ◽

Gabi Topor ◽

Adrian Beznea ◽

Roxana Vasluianu

Keyword(s):

Calcium Phosphate ◽

Amorphous Calcium Phosphate ◽

Control Group ◽

Invasive Treatment ◽

Treatment Groups ◽

Non Invasive ◽

Group 4 ◽

Group 2 ◽

Casein Phosphopeptide ◽

Caries Lesions

The aim of the present study was to assess the remineralizing potential of 10% casein phosphopeptide-amorphous calcium phosphate complex (CPP-ACP) -Recaldent used alone or with fluoride (CPP-ACFP) as compared to fluoride mouthrinse for the non-invasive treatment of occlusal non-cavitary caries lesions in vivo.A total of eighty subjects were randomly assigned to four groups, i.e. group 1 - 10% CPP-ACP, group 2- 10% CPP-ACP + 0.2% NaF, group 3- 0.05% NaF mouthrinse and group 4 �control. The lesions were assessed using visual examination and DIAGNOdent measurements. After 12 weeks of using the corresponding product, the results showed that the highest decrease in fluorescence was produced by CPP-ACFP (from 16.28�1.40 to 6.53�0.59, p=0.002), followed by CPP-ACP (from 15.70�1.82 to 8.18�0.70, p=0.004) and fluoride mouthrinse (from 14.32�1.72 to 7.88�0.68, p=0.005), significantly higher than in the control group (p[0.05). No significant differences were found between the three treatment groups.

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Anticariogenicity of Casein Phosphopeptide-amorphous Calcium Phosphate: A Review of the Literature

The Journal of Contemporary Dental Practice ◽

10.5005/jcdp-10-3-1 ◽

2009 ◽

Vol 10 (3) ◽

pp. 1-9 ◽

Cited By ~ 39

Author(s):

Carmen Llena ◽

Leopoldo Forner ◽

Pilar Baca

Keyword(s):

Calcium Phosphate ◽

Amorphous Calcium Phosphate ◽

Soluble Form ◽

Review Of The Literature ◽

Dental Biofilm ◽

Essential Components ◽

Casein Phosphopeptide ◽

Bioavailable Calcium ◽

Caries Lesions

Abstract Aim This review of the literature examines the role of the natural components of saliva in maintaining tooth mineralization and the role of different casein phosphopeptide amorphous calcium phosphate-based (CPP-ACP) compounds in controlling demineralization/ remineralization and their clinical applications. Background A group of peptides, known as CPP, have been shown to stabilize calcium and phosphate preserving them in an amorphous or soluble form known as amorphous calcium phosphate (ACP). Calcium and phosphate are essential components of enamel and dentine and form highly insoluble complexes, but in the presence of CPP they remain soluble and biologically available. This CPP-ACP complex applied to teeth by means of chewing-gum, toothpaste, lozenges, mouth rinses, or sprays is able to adhere to the dental biofilm and enamel hydroxyapatite providing bioavailable calcium and phosphate ions. Review Results Significantly high levels of calcium and phosphate have been found in both biofilm and subsurface incipient caries lesions and in lower level demineralization of enamel or dentine surfaces previously treated with CPP-ACP based compounds. When placed on the surface of a tooth with early carious lesions, pastes with CPP-ACP complexes can prevent tooth demineralization and improve enamel remineralization and enhance fluoride activity. Conclusion Remineralization of white spot lesions has been achieved clinically by applying pastes based on these compounds, and a similar effect to self-applied fluorides has been observed in reducing the appearance of new caries lesions in patients with xerostomia. Clinical Significance Use of CPP-ACP based compounds offers a potential for use in the prevention of dental caries. Citation Llena C, Forner L, Baca P. Anticariogenicity of Casein Phosphopeptide-amorphous Calcium Phosphate: A Review of the Literature. J Contemp Dent Pract 2009 May; (10)3:001-009.

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