Multifocal electroretinography-assisted anatomical and functional evaluation of subthreshold green laser in acute central serous chorioretinopathy

Abstract Background To evaluate the functional and structural abnormalities in patients with acute central serous chorioretinopathy (CSC) by multifocal electroretinography (mfERG) and enhanced depth imaging optical coherence tomography (EDI-OCT) Methods This prospective observational study included 57 patients with unilateral CSC. Both eyes underwent mfERG and EDI-OCT. Peak amplitudes and implicit times of the ﬁrst kernel responses were analyzed and compared with those in 25 age-matched normal controls. Correlational analyses were performed between the mfERG results and EDI-OCT parameters. The thicknesses of the central retina, subretinal fluid, and choroid was measured at baseline and 3 months later. Results Compared with the normal controls, the amplitude and implicit time on mfERG were significantly impaired in the area with serous retinal detachment (SRD). The P1 amplitude and implicit time of the areas beyond the SRD were also found to be significantly impaired in the affected eyes. Eyes with a greater reduction in SRD had a less impaired mfERG response in fellow eyes than those whose retinal detachments were not spontaneously decreased by more than 90% after 3 months. Correlational analysis did not reveal any significant correlations between mfERG values and OCT parameters except for central choroidal thickness. The subfoveal choroidal thickness was negatively correlated with the mfERG parameters. Conclusion The findings of this study indicate diffuse functional impairment in acute CSC which involves both eyes and areas beyond the SRD. The retinal response of the unaffected eye was associated with regression of SRD and functional retinal abnormality is correlated with pathological changes in the choroid.

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First and second-order kernel multifocal electroretinography abnormalities in acute central serous chorioretinopathy

Documenta Ophthalmologica ◽

10.1007/s10633-007-9075-8 ◽

2007 ◽

Vol 116 (1) ◽

pp. 29-40 ◽

Cited By ~ 13

Author(s):

Timothy Y. Y. Lai ◽

Ricky Y. K. Lai ◽

Jasmine W. S. Ngai ◽

Wai-Man Chan ◽

Haitao Li ◽

...

Keyword(s):

Central Serous Chorioretinopathy ◽

Second Order ◽

Multifocal Electroretinography ◽

Acute Central Serous Chorioretinopathy ◽

Order Kernel

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Macular pigment optical density in central serous chorioretinopathy

Therapeutic Advances in Ophthalmology ◽

10.1177/2515841421997195 ◽

2021 ◽

Vol 13 ◽

pp. 251584142199719

Author(s):

Burcu Polat Gultekin ◽

Esra Sahli

Keyword(s):

Confidence Interval ◽

Optical Density ◽

Central Serous Chorioretinopathy ◽

Choroidal Thickness ◽

Retinal Thickness ◽

Macular Pigment ◽

Central Retinal Thickness ◽

Macular Pigment Optical Density ◽

Chronic Central Serous Chorioretinopathy ◽

Acute Central Serous Chorioretinopathy

Purpose: The aim of our study was to evaluate the macular pigment optical density in patients with acute and chronic central serous chorioretinopathy and to describe the association between central retinal thickness and choroidal thickness with the macular pigment optical density. Materials and Methods: Eyes with acute central serous chorioretinopathy and chronic central serous chorioretinopathy (patients, who were diagnosed as having disease activity for 6 months) were included in this study. Macular pigment was measured using the heterochromatic flicker technique of the MPS II device for both eyes in patients with acute and chronic central serous chorioretinopathy and in control subjects. Results: Twenty-seven eyes with acute central serous chorioretinopathy, 23 eyes with chronic central serous chorioretinopathy, and 25 control eyes were enrolled. The mean macular pigment optical density in chronic central serous chorioretinopathy (0.480 ± 0.16 density unit (95% confidence interval: 0.390–0.570) was found to be significantly lower than in the control eyes (0.571 ± 0.128 density unit) (95% confidence interval: 0.480–0.670) ( p = 0.007). In correlation analysis, no significant association was detected between the central retinal thickness, choroidal thickness, and macular pigment optical density values in central serous chorioretinopathy group ( p = 0.31, p = 0.71). Conclusion: Macular pigment optical density levels were significantly lower in chronic central serous chorioretinopathy patients than in controls, possibly due to degeneration of the neurosensorial retina, as a result of the long-term persistence of subretinal fluid. There was not a significant correlation between choroidal thickness and macular pigment optical density levels in central serous chorioretinopathy group.

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