Recurrent vitreous hemorrhage secondary to retinal vessel avulsion

MicroRNAs (miRNAs) can provide insight into the pathophysiological states of ocular tissues such as proliferative diabetic retinopathy (PDR). In this study, differences in miRNA expression in vitreous from PDR patients with and without incidence of recurrent vitreous hemorrhage (RVH) after the initial pars-plana vitrectomy (PPV) were analyzed, with the aim of identifying biomarkers for RVH. Fifty-four consented vitreous samples were analyzed from patients undergoing PPV for PDR, of which eighteen samples underwent a second surgery due to RVH. Ten of the sixty-six expressed miRNAs (miRNAs-19a, -20a, -22, -27a, -29a, -93, -126, -128, -130a, and -150) displayed divergences between the PDR vitreous groups and to the control. A significant increase in the miRNA-19a and -27a expression was determined in PDR patients undergoing PPV as compared to the controls. miRNA-20a and -93 were significantly upregulated in primary PPV vitreous samples of patients afflicted with RVH. Moreover, this observed upregulation was not significant between the non-RVH and control group, thus emphasizing the association with RVH incidence. miRNA-19a and -27a were detected as putative vitreous biomarkers for PDR, and elevated levels of miRNA-20a and -93 in vitreous with RVH suggest their biomarker potential for major PDR complications such as recurrent hemorrhage incidence.

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Haptic-induced recurrent vitreous hemorrhage and increased intraocular pressure with a hydrophobic acrylic intraocular lens

Journal of Cataract & Refractive Surgery ◽

10.1016/j.jcrs.2008.08.043 ◽

2009 ◽

Vol 35 (2) ◽

pp. 399-402 ◽

Cited By ~ 7

Author(s):

Fernando C. Trindade

Keyword(s):

Intraocular Pressure ◽

Intraocular Lens ◽

Vitreous Hemorrhage ◽

Hydrophobic Acrylic ◽

Recurrent Vitreous Hemorrhage

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RECURRENT VITREOUS HEMORRHAGE AFTER SUTURED POSTERIOR CHAMBER INTRAOCULAR LENSES

Retina ◽

10.1097/00006982-200404000-00001 ◽

2004 ◽

Vol 24 (2) ◽

pp. 193-198 ◽

Cited By ~ 8

Author(s):

ARTHUR D. FU ◽

H. RICHARD MCDONALD ◽

J. MICHAEL JUMPER ◽

THOMAS M. AABERG ◽

WILLIAM E. SMIDDY ◽

...

Keyword(s):

Vitreous Hemorrhage ◽

Intraocular Lenses ◽

Posterior Chamber ◽

Recurrent Vitreous Hemorrhage

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ROLE OF INTRAVITREAL BEVACIZUMAB (AVASTIN) INJECTED AT THE END OF DIABETIC VITRECTOMY IN PREVENTING POSTOPERATIVE RECURRENT VITREOUS HEMORRHAGE

Retina ◽

10.1097/iae.0b013e3181d6def0 ◽

2010 ◽

Vol 30 (10) ◽

pp. 1646-1650 ◽

Cited By ~ 25

Author(s):

Rizwan A Cheema ◽

Javed Mushtaq ◽

Wajeeha Al-Khars ◽

Essam Al-Askar ◽

Maheera A Cheema

Keyword(s):

Intravitreal Bevacizumab ◽

Vitreous Hemorrhage ◽

Diabetic Vitrectomy ◽

Recurrent Vitreous Hemorrhage

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Recurrent Vitreous Hemorrhage Secondary to Sulcus Positioning of a One-Piece Acrylic Intraocular Lens Haptic: Report of 3 Cases and Management With Retrocapsular Haptic Repositioning

Journal of VitreoRetinal Diseases ◽

10.1177/2474126417717569 ◽

2017 ◽

Vol 1 (5) ◽

pp. 328-330 ◽

Cited By ~ 1

Author(s):

Dimosthenis Mantopoulos ◽

Jonathan L. Prenner ◽

H. Matthew Wheatley

Keyword(s):

Intraocular Lens ◽

Vitreous Hemorrhage ◽

Single Piece ◽

Simple Alternative ◽

Recurrent Vitreous Hemorrhage ◽

Capsular Bag ◽

Iol Exchange

Three pseudophakic patients presented with recurrent, unilateral vitreous hemorrhage, one of which also had uveitis, glaucoma, and hyphema, consistent with “uveitis–glaucoma–hyphema (UGH)-Plus” syndrome. Arcuate transillumination defects secondary to inadvertent placement of 1 intraocular lens (IOL) haptic in the sulcus were identified in each case. The second haptic and optic were located in the capsular bag. The IOLs were all single-piece foldable acrylic lenses with square-edge haptic design. Surgical repositioning of the malpositioned haptic from the sulcus to the retrocapsular space resulted in the resolution of the recurrent vitreous hemorrhage. This series highlights the fact that recurrent vitreous hemorrhage secondary to iris chafing, with or without UGH, may occur in cases where a square-edge IOL haptic is placed in the sulcus. Vitrectomy with repositioning of the malpositioned IOL is a simple alternative to IOL exchange in these cases.

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Intravitreal Bevacizumab for Proliferative Sickle Retinopathy: A Case Series

Journal of VitreoRetinal Diseases ◽

10.1177/2474126417738627 ◽

2017 ◽

Vol 2 (1) ◽

pp. 32-38 ◽

Cited By ~ 5

Author(s):

Cindy X. Cai ◽

Marguerite O. Linz ◽

Adrienne W. Scott

Keyword(s):

Sickle Cell ◽

Large Scale ◽

Case Series ◽

Intravitreal Bevacizumab ◽

Vitreous Hemorrhage ◽

Beta Thalassemia ◽

Intravitreal Bevacizumab Injection ◽

Initial Injection ◽

Sea Fan ◽

Recurrent Vitreous Hemorrhage

Purpose: To report outcomes of intravitreal bevacizumab therapy for proliferative sickle retinopathy (PSR). Methods: A retrospective, interventional case series. Five eyes of 5 patients with PSR were managed with intravitreal bevacizumab therapy over a 13-year period at a single institution. Results: Four patients had sickle cell-hemoglobin SC disease and 1 had sickle cell-beta thalassemia disease. Four of the patients treated with intravitreal bevacizumab injection were treated for recurrent vitreous hemorrhage and 1 was treated for new peripheral sea fan neovascularization. In those patients treated for vitreous hemorrhage, there was improvement in visual acuity as early as 2 weeks after treatment. Only 2 of the patients had documented recurrent vitreous hemorrhage during the period of follow-up after the initial injection. In 1 patient, the vitreous hemorrhage did not recur until 13 months after the injection. All patients showed an anatomic response to intravitreal bevacizumab therapy with partial regression of the peripheral sea fan neovascularization. All patients tolerated the injections without any complications. Conclusions: Intravitreal bevacizumab injections appear to be well tolerated and may be an effective treatment of PSR. Regression of peripheral sea fan neovascularization and decreased duration of vitreous hemorrhage may be observed. Large-scale randomized controlled trials are needed to further clarify the role of bevacizumab in PSR.

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