Best practices of handling, processing, and interpretation of small intestinal biopsies for the diagnosis and management of celiac disease: A joint consensus of Indian association of pathologists and microbiologists and Indian society of gastroenterology

The ingestion of wheat gliadin (alcohol-soluble proteins, an integral part of wheat gluten) and related proteins induce, in genetically predisposed individuals, celiac disease (CD), which is characterized by immune-mediated impairment of the small intestinal mucosa. The lifelong omission of gluten and related grain proteins, i.e., a gluten-free diet (GFD), is at present the only therapy for CD. Although a GFD usually reduces CD symptoms, it does not entirely restore the small intestinal mucosa to a fully healthy state. Recently, the participation of microbial components in pathogenetic mechanisms of celiac disease was suggested. The present review provides information on infectious diseases associated with CD and the putative role of infections in CD development. Moreover, the involvement of the microbiota as a factor contributing to pathological changes in the intestine is discussed. Attention is paid to the mechanisms by which microbes and their components affect mucosal immunity, including tolerance to food antigens. Modulation of microbiota composition and function and the potential beneficial effects of probiotics in celiac disease are discussed.

Download Full-text

Small intestinal permeability to mannitol, lactulose, and polyethylene glycol 400 in celiac disease

Digestive Diseases and Sciences ◽

10.1007/bf01318423 ◽

1984 ◽

Vol 29 (9) ◽

pp. 809-816 ◽

Cited By ~ 77

Author(s):

S. O. Ukabam ◽

B. T. Cooper

Keyword(s):

Celiac Disease ◽

Polyethylene Glycol ◽

Intestinal Permeability ◽

Polyethylene Glycol 400 ◽

Small Intestinal

Download Full-text

Australasian Pediatric Gastroenterologists’ Perspectives and Practices of Celiac Disease Diagnosis and Management

Digestive Diseases and Sciences ◽

10.1007/s10620-021-06988-2 ◽

2021 ◽

Author(s):

Shaun S. C. Ho ◽

Sophie Hall ◽

Jacqueline I. Keenan ◽

Andrew S. Day

Keyword(s):

Celiac Disease ◽

Disease Diagnosis ◽

Diagnosis And Management ◽

Celiac Disease Diagnosis

Download Full-text

Collagenous Sprue: A Rare, Severe Small-Bowel Malabsorptive Disorder

Archives of Pathology & Laboratory Medicine ◽

10.5858/2010-0028-rs.1 ◽

2011 ◽

Vol 135 (6) ◽

pp. 803-809

Author(s):

Xiangrong Zhao ◽

Rebecca L. Johnson

Keyword(s):

Celiac Disease ◽

Medical Literature ◽

Case Reports ◽

Disease Entity ◽

Review Of The Literature ◽

Molecular Features ◽

Refractory Sprue ◽

Exact Etiology ◽

Sporadic Cases ◽

Small Intestinal

Abstract Collagenous sprue is a severe malabsorptive disorder, histologically characterized by small intestinal villous and crypt atrophy, and a subepithelial collagen deposit, thicker than 12 µm, that entraps lamina propria cellular elements. Collagenous sprue is a rare disease entity, with only about 60 sporadic cases reported worldwide since it was first described in 1947. Its exact etiology is still under investigation, and its relationship with classic celiac disease and other refractory, spruelike intestinal disorders remains controversial. Two larger-scale studies, in 2009, brought new insights into this elusive, yet emerging, topic. Here, we present a review of the literature on the possible etiology of collagenous sprue, its proposed links to classic celiac disease and to refractory sprue, and its clinical, biochemical, histologic, and molecular features. To our knowledge, all case reports on collagenous sprue in the medical literature to date are summarized.

Download Full-text