The prognostic value of preoperative serum albumin-globulin ratio for high-grade bladder urothelial carcinoma treated with radical cystectomy: A propensity score-matched analysis

Abstract Background: To investigate the perioperative efficacy and cost of robot-assisted radical cystectomy(RARC) and laparoscopic RC(LRC) in patients with non-advanced bladder urothelial carcinomaMethods: 156 patients with non-advanced bladder urothelial carcinoma undergoing minimally invasive radical cystectomy in our center between January 2015 and April 2020 were included. Perioperative data and hospitalization expenses were extracted from our database. All analyses were performed using SPSS 23.0 software, and p < 0.05 was considered statistically significant.Results: The proportion of male patients was 86.5%(135/156) and the median age was 65(IQR 59-71) years old. RARC had a lower PSM rate (0 vs 5.3%,P=0.051), longer median operation time(370 vs 305 min,P<0.001) and higher median hospitalization cost(20565.2 vs 15532.4$,P<0.001). There were no significant differences in intraoperative transfusion rate, anesthesia resuscitation in ICU, postoperative hospital stay, 30-d complications and postoperative treatment expenses between the two groups(P=0.815,0.715, 0.817,0.92 and 0.543,respectively.)Conclusion: Short operation time and low hospitalization costs are favorable factors for LRC, but RARC may be the preferred surgical procedure for non-advanced bladder urothelial carcinoma considering the potentially low PSM rate.Trial registration: A complete informed consent was obtained from the patient and their families before the surgery.Informed consent was signed for all patients.This study was approved by the Ethics Review Committee of the Second Xiangya Hospital of Central South University

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Prognostic value of TOP2A in bladder urothelial carcinoma and potential molecular mechanisms

BMC Cancer ◽

10.1186/s12885-019-5814-y ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 6

Author(s):

Shuxiong Zeng ◽

Anwei Liu ◽

Lihe Dai ◽

Xiaowen Yu ◽

Zhensheng Zhang ◽

...

Keyword(s):

Urothelial Carcinoma ◽

Prognostic Value ◽

Molecular Mechanisms ◽

Bladder Urothelial Carcinoma

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The prognostic significance of preoperative serum albumin in urothelial carcinoma: a systematic review and meta-analysis

Bioscience Reports ◽

10.1042/bsr20180214 ◽

2018 ◽

Vol 38 (4) ◽

Cited By ~ 10

Author(s):

Jing Liu ◽

Fang Wang ◽

Shaohong Li ◽

Wenhui Huang ◽

Yanjuan Jia ◽

...

Keyword(s):

Serum Albumin ◽

Urothelial Carcinoma ◽

Serum Albumin Level ◽

Meta Analysis ◽

Prognostic Significance ◽

Albumin Level ◽

Cochrane Library ◽

Tumor Type ◽

Poor Overall Survival ◽

Preoperative Serum

Preoperative serum albumin has been considered to be closely correlated with the prognosis of various cancers, including urothelial carcinoma (UC). However, to date, this conclusion remains controversial. The aim of this meta-analysis is to investigate the prognostic significance of preoperative serum albumin in UC. A literature search was performed in PubMed, Web of Science, Embase, and Cochrane Library up to 4 July 2017. Herein, a total of 15506 patients from 23 studies were enrolled in our meta-analysis. Decreased preoperative serum albumin level predicted poor overall survival (OS) (HR = 1.88, 95% CI: 1.44–2.45, P<0.0001), cancer-specific survival (CSS) (HR = 2.03, 95% CI: 1.42–2.90, P=0.0001), recurrence-free survival (HR = 1.85, 95% CI: 1.15–2.97, P=0.01), 30-day complications (30dCs) after surgery (odds ratio (OR) = 1.93, 95% CI: 1.16–3.20, P=0.01), and 90-day mortality after surgery (OR = 4.24, 95% CI: 2.20–8.16, P<0.001). The subgroup analyses indicated that low preoperative serum albumin level is still positively associated with a worse prognosis of UC based on ethnicity, cut-off value, tumor type, analyses type, and sample size. Our meta-analysis indicated that reduced preoperative serum albumin level was a predictor of poor prognosis of UC.

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