scholarly journals Prognostic value of TOP2A in bladder urothelial carcinoma and potential molecular mechanisms

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Shuxiong Zeng ◽  
Anwei Liu ◽  
Lihe Dai ◽  
Xiaowen Yu ◽  
Zhensheng Zhang ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Prognostic Value ◽  
Molecular Mechanisms ◽  
Bladder Urothelial Carcinoma

scholarly journals Genome-Wide Analyses of Prognostic and Therapeutic Alternative Splicing Signatures in Bladder Urothelial Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhongru Fan ◽  
Zhe Zhang ◽  
Chiyuan Piao ◽  
Zhuona Liu ◽  
Zeshu Wang ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Alternative Splicing ◽  
Urothelial Carcinoma ◽  
Prognostic Value ◽  
Gap Analysis ◽  
Unsupervised Cluster ◽  
Chemotherapy Drugs ◽  
Genome Wide ◽  
Bladder Urothelial Carcinoma ◽  
Unsupervised Cluster Analysis

BackgroundAlternative splicing (AS) is an indispensable post-transcriptional modification applied during the maturation of mRNA, and AS defects have been associated with many cancers. This study was designed to thoroughly analyze AS events in bladder urothelial carcinoma (BLCA) at the genome-wide level.MethodsWe adopted a gap analysis to screen for significant differential AS events (DASEs) associated with BLCA. DASEs with prognostic value for OS and the disease-free interval (DFI) were identified by Cox analysis. In addition, a differential AS network and AS clusters were identified using unsupervised cluster analysis. We examined differences in the sensitivity to chemotherapy and immunotherapy between BLCA patients with high and low overall survival (OS) risk.ResultsAn extensive number of DASEs (296) were found to be clinically relevant in BLCA. A prognosis model was established based prognostic value of OS and DFI. CUGBP elav-like family member 2 (CELF2) was identified as a hub splicing factor for AS networks. We also identified AS clusters associated with OS using unsupervised cluster analysis, and we predicted that the effects of cisplatin and gemcitabine chemotherapy would be different between high- and low-risk groups based on OS prognosis.ConclusionWe completed a comprehensive analysis of AS events in BLCA at the genome-wide level. The present findings revealed that DASEs and splicing factors tended to impact BLCA patient survival and sensitivity to chemotherapy drugs, which may provide novel prospects for BLCA therapies.

scholarly journals Significant Prognostic Value of the Autophagy-Related Gene P4HB in Bladder Urothelial Carcinoma

2020 ◽  
Vol 10 ◽  
Author(s):  
Lei Lyu ◽  
Wei Xiang ◽  
Fuxin Zheng ◽  
Tao Huang ◽  
Yan Feng ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Prognostic Value ◽  
Related Gene ◽  
Bladder Urothelial Carcinoma

scholarly journals Assessment of molecular mechanisms and potential biomarkers in bladder urothelial carcinoma

Acta Medica ◽  
2019 ◽  
Vol 50 (2) ◽  
pp. 8-15
Author(s):  
Ceren Sucularlı
Keyword(s):  
Cell Cycle ◽  
Urothelial Carcinoma ◽  
Molecular Mechanisms ◽  
Patient Survival ◽  
Smooth Muscle Contraction ◽  
Receptor Interaction ◽  
Ppi Networks ◽  
Normal Bladder ◽  
Bladder Urothelial Carcinoma ◽  
Potential Biomarkers

Objective: Bladder cancer ranks 10th among the most common cancers worldwide, effecting mostly man than women. The aim of this study is to perform a detailed gene expression analysis of bladder urothelial carcinoma to reveal altered molecular mechanisms and to find potential biomarkers for this cancer. Materials and Methods: Bladder urothelial carcinoma RNA-seq data from TCGA and normal bladder samples from GTEx were analyzed by using GEPIA. Differentially expressed genes were annotated to GO-BP and KEGG pathway terms with DAVID and PPI networks were constructed by STRING. The association of upregulated cell cycle pathway proteins and patient survival was further investigated. Results: Upregulated genes mainly annotated to cell cycle, p53 signaling and oocyte meiosis and maturation pathways and cell cycle related GO-BP terms. Downregulated genes mostly annotated to adhesion, ECM-receptor interaction, vascular smooth muscle contraction and cardiomyopathy related KEGG pathways and muscle related GO-BP terms. The protein products of six cell cycle genes, which were upregulated in bladder urothelial carcinoma, showed significant association with patient survival. Conclusion: The results of this study showed altered molecular mechanisms and increased our understanding in bladder urothelial carcinoma, proposed potential prognostic biomarkers.  

Prognostic value of hypoxia gene expression in bladder cancer patients.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 548-548
Author(s):  
Hyun Chang ◽  
Seung-Hyun Lee ◽  
Taeryool Koo ◽  
Moon Ho Kim ◽  
Soo-Yoon Sung
Keyword(s):  
Bladder Cancer ◽  
Urothelial Carcinoma ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Cox Regression ◽  
Gene Signature ◽  
Survival Curves ◽  
Kaplan Meier ◽  
Bladder Urothelial Carcinoma

548 Background: The prognostic value of hypoxia in bladder cancer remains unknown. We aimed to evaluate the potential role of hypoxia gene signature as prognostic factors in bladder cancer patients. Methods: We investigated the hypoxia gene signature and clinicopathologic features of The Cancer Genome Atlas (TCGA) bladder urothelial carcinoma (n = 408) using the Kaplan-Meier survival curves and multivariate Cox regression analyses. The clinicopathologic data and the processed data of hypoxia gene signature were obtained from TCGA Bladder urothelial carcinoma database. Results: Hypoxia gene signature score was significantly associated with overall survival (OS) and progression-free survival (PFS). Higher score resulted in shorter OS and PFS in Kaplan-Meier survival curves with Log-rank test ( P < 0.01 and P <0.05, respectively). In multivariate analysis containing clinical prognostic variables, higher hypoxia gene signature score predicted poor OS (adjusted HR= 1.58, 95% CI 1.15 - 2.19; P <0.01). Conclusions: Hypoxia gene signature was an independent prognostic factor in bladder cancer. Prospective studies are needed to evaluate the prognostic role of hypoxia in bladder cancer patients.

scholarly journals Construction of Protein-related Risk Score Model in Bladder Urothelial Carcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Qizhan Luo ◽  
Xiaobo Zhang
Keyword(s):  
Urothelial Carcinoma ◽  
Risk Score ◽  
Molecular Mechanisms ◽  
Cox Regression ◽  
Cox Regression Analysis ◽  
Immune Infiltration ◽  
Related Risk ◽  
Bladder Urothelial Carcinoma ◽  
Score Model ◽  
Related Proteins

Background. Though there are several prognostic models, there is no protein-related prognostic model. The aim of this study is to identify possible prognostic-related proteins in bladder urothelial carcinoma and to try to predict the prognosis of bladder urothelial carcinoma based on these proteins. Methods. Profile data and corresponding clinical traits were obtained from The Cancer Proteome Atlas (TCPA) and The Cancer Genome Atlas (TCGA) expression. Survival-associated protein in bladder urothelial carcinoma patients were estimated with Kaplan-Meier (KM) test and COX regression analysis. The potential molecular mechanisms and properties of these bladder urothelial carcinoma-specific proteins were also explored with the help of computational skills. The risk score model was validated in different clinical traits. Sankey diagram representation is for protein correlation. A new prognostic-related risk model based on proteins was developed by using multivariable COX analysis. Next, the alteration of the corresponding genes to the 6 prognostic-related proteins was analyzed. Finally, the relation between the corresponding genes and the immune infiltration was analyzed using the TIMER. Results. Six proteins were identified to be associated with the prognosis of bladder urothelial carcinoma. A prognostic signature based on proteins (BECLIN, EGFR, PKCALPHA, SRC, ANNEXIN1, and AXL) performed moderately in prognostic predictions. The alteration of corresponding genes was in 31(24%) sequenced cases. ANXA1, AXL, and EGFR were positively related to CD8+ T cell. Conclusion. Our results screened six proteins of clinical significance. The importance of a personalized protein signature model in the recognition, surveillance. The abnormal expression of six prognostic-related proteins may be caused by corresponding gene alteration. Furthermore, these proteins may affect survival via the immune infiltration.

scholarly journals Keratin 17 Immunohisto chemical Expression and Prognostic Value in Bladder Urothelial Carcinoma

2019 ◽  
Vol 87 (12) ◽  
pp. 4737-4746
Author(s):  
SHAIMAA M.M. BEBARS, M.D.; WALAA ABD EL GAWAD GHANAM, M.D. ◽  
RASHA MOHAMED SAMIR SAID, M.D.
Keyword(s):  
Urothelial Carcinoma ◽  
Prognostic Value ◽  
Bladder Urothelial Carcinoma ◽  
Keratin 17
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