Effect of Zingiber officinale Roscoe rhizome (ginger) capsule on postpartum pain: Double-blind randomized clinical trial

Background Previous studies have shown an analgesic effect of ginger in the acute treatment of migraine, and there is anecdotal evidence of its efficacy in migraine prophylaxis. Objective This study aimed to evaluate the potential of ginger to prevent migraine attacks. Methods This double-blind, placebo-controlled randomized clinical trial took place at the Headache Clinic, Universidade Federal de Minas Gerais (Belo Horizonte, Minas Gerais, Brazil), involving 107 patients. Only subjects diagnosed with episodic migraine, aged between 18 and 60 years old, and who were not taking any prophylactic medication, were enrolled in the study. After one month of observation, subjects selected for the study were randomized 1:1 into placebo and treatment groups. Patients received capsules three times per day of 200 mg of dry extract of ginger (5% active ingredient) or placebo (cellulose) for three months. Visits were performed monthly and the patients were asked to fill in a migraine diary. The adherence to treatment was evaluated by counting capsules. Results The percentage of patients who responded to treatment (i.e. a reduction of 50% in the number of migraine attacks at the end of treatment) did not differ between the groups. There was a decrease in the number of days with severe pain, analgesic use for acute migraine and duration of migraine attacks in both groups, without significant difference between ginger and placebo groups. Conclusions Ginger provides no greater benefit in the prophylactic treatment of migraine when compared to placebo. This trial is registered at ClinicalTrials.gov (NCT02570633).

Download Full-text

The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial

International Journal of Reproductive BioMedicine ◽

10.29252/ijrm.14.8.533 ◽

2016 ◽

Vol 14 (8) ◽

pp. 533-540 ◽

Cited By ~ 4

Author(s):

Jalil Hosseini ◽

Azar Mardi Mamaghani ◽

Hani Hosseinifar ◽

Mohammad Ali Sadighi Gilani ◽

Farid Dadkhah ◽

...

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Dna Fragmentation ◽

Sperm Quality ◽

Zingiber Officinale ◽

Human Sperm ◽

Double Blind

Download Full-text

Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) addition in migraine acute treatment

Cephalalgia ◽

10.1177/0333102418776016 ◽

2018 ◽

Vol 39 (1) ◽

pp. 68-76 ◽

Cited By ~ 11

Author(s):

Laís Bhering Martins ◽

Ana Maria dos Santos Rodrigues ◽

Débora Fernandes Rodrigues ◽

Luana Caroline dos Santos ◽

Antônio Lúcio Teixeira ◽

...

Keyword(s):

Clinical Trial ◽

Functional Status ◽

Migraine Attack ◽

Randomized Clinical Trial ◽

Zingiber Officinale ◽

Episodic Migraine ◽

Migraine Treatment ◽

Ginger Extract ◽

Double Blind ◽

Double Blind Placebo

Background Previous studies have demonstrated the analgesic effects of ginger in different conditions, but evidence about its efficacy in migraine treatment is scarce. Objective This study aimed to evaluate the potential of ginger to improve acute migraine as an add-on strategy to standard treatment. Methods A double-blind placebo-controlled randomized clinical trial in the emergency room of a general hospital was conducted. Patients who sought medical care at the time of migraine attack were enrolled in this study. Only adults with episodic migraine (one to six migraine attacks per month) with or without aura were included. Sixty participants were randomized into two groups in which they received 400 mg of ginger extract (5% active ingredient) or placebo (cellulose), in addition to an intravenous drug (100 mg of ketoprofen) to treat the migraine attack. Patients filled a headache diary before, 0.5 h, 1 h, 1.5 h and 2 h after the medication. Pain severity, functional status, migraine symptoms and treatment satisfaction were also recorded. Results Patients treated with ginger showed significantly better clinical response after 1 h ( p = 0.04), 1.5 h ( p = 0.01) and 2 h ( p = 0.04). Furthermore, ginger treatment promoted reduction in pain and improvement on functional status at all times assessed. Conclusions The addition of ginger to non-steroidal anti-inflammatory drugs may contribute to the treatment of migraine attack. This trial is registered at ClinicalTrials.gov (NCT02568644)

Download Full-text