scholarly journals Regulation of IgE-Mediated Food Allergy by IL-9 Producing Mucosal Mast Cells and Type 2 Innate Lymphoid Cells

2016 ◽  
Vol 16 (4) ◽  
pp. 211 ◽  
Author(s):  
Jee-Boong Lee
Keyword(s):  
Food Allergy ◽  
Mast Cells ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Mucosal Mast Cells ◽  
Ige Mediated

scholarly journals Developing food allergy: a potential immunologic pathway linking skin barrier to gut

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2660 ◽  
Author(s):  
Yui-Hsi Wang
Keyword(s):  
Food Allergy ◽  
Mast Cells ◽  
Immunoglobulin E ◽  
Lymphoid Cells ◽  
Th2 Cells ◽  
Allergic Reactions ◽  
Mucosal Mast Cells ◽  
Life Threatening ◽  
Ige Mediated

Immunoglobulin E (IgE)-mediated food allergy is an adverse reaction to foods and is driven by uncontrolled type-2 immune responses. Current knowledge cannot explain why only some individuals among those with food allergy are prone to develop life-threatening anaphylaxis. It is increasingly evident that the immunologic mechanisms involved in developing IgE-mediated food allergy are far more complex than allergic sensitization. Clinical observations suggest that patients who develop severe allergic reactions to food are often sensitized through the skin in early infancy. Environmental insults trigger epidermal thymic stromal lymphopoietin and interleukin-33 (IL-33) production, which endows dendritic cells with the ability to induce CD4+TH2 cell-mediated allergic inflammation. Intestinal IL-25 propagates the allergic immune response by enhancing collaborative interactions between resident type-2 innate lymphoid cells and CD4+TH2 cells expanded by ingested antigens in the gastrointestinal tract. IL-4 signaling provided by CD4+TH2 cells induces emigrated mast cell progenitors to become multi-functional IL-9-producing mucosal mast cells, which then expand greatly after repeated food ingestions. Inflammatory cytokine IL-33 promotes the function and maturation of IL-9-producing mucosal mast cells, which amplify intestinal mastocytosis, resulting in increased clinical reactivity to ingested food allergens. These findings provide the plausible view that the combinatorial signals from atopic status, dietary allergen ingestions, and inflammatory cues may govern the perpetuation of allergic reactions from the skin to the gut and promote susceptibility to life-threatening anaphylaxis. Future in-depth studies of the molecular and cellular factors composing these stepwise pathways may facilitate the discovery of biomarkers and therapeutic targets for diagnosing, preventing, and treating food allergy.

scholarly journals IgE promotes type 2 innate lymphoid cells in murine food allergy

2018 ◽  
Vol 48 (3) ◽  
pp. 288-296 ◽  
Author(s):  
O. T. Burton ◽  
J. Medina Tamayo ◽  
A. J. Stranks ◽  
S. Miller ◽  
K. J. Koleoglou ◽  
...  
Keyword(s):  
Food Allergy ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells

scholarly journals Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy

Immunity ◽  
2015 ◽  
Vol 43 (4) ◽  
pp. 788-802 ◽  
Author(s):  
Chun-Yu Chen ◽  
Jee-Boong Lee ◽  
Bo Liu ◽  
Shoichiro Ohta ◽  
Pin-Yi Wang ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mast Cells ◽  
Mucosal Mast Cells ◽  
Ige Mediated ◽  
Interleukin 9

scholarly journals Germ-free mice exhibit mast cells with impaired functionality and gut homing and do not develop food allergy

2018 ◽  
Author(s):  
Martin Schwarzer ◽  
Petra Hermanova ◽  
Dagmar Srutkova ◽  
Jaroslav Golias ◽  
Tomas Hudcovic ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mast Cells ◽  
Specific Ige ◽  
Edema Formation ◽  
Germ Free ◽  
Mechanistic Insight ◽  
Mucosal Mast Cells ◽  
Ige Mediated ◽  
Low Levels ◽  
Insight Into

ABSTRACTBackgroundMucosal mast cells (MC) are key players in IgE-mediated food allergy (FA). The evidence on the interaction between gut microbiota, MC and susceptibility to FA is contradictory.ObjectiveWe tested the hypothesis that commensal bacteria are essential for MC migration to the gut and their maturation impacting the susceptibility to FA.MethodsThe development and severity of FA symptoms was studied in sensitized germ-free (GF), conventional (CV) and mice mono-colonized with L. plantarum WCFS1 or co-housed with CV mice. MC were phenotypically and functionally characterized.ResultsSystemic sensitization and oral challenge of GF mice with ovalbumin led to increased levels of specific IgE in serum compared to CV mice. Remarkably, despite the high levels of sensitization, GF mice did not develop diarrhea or anaphylactic hypothermia, common symptoms of FA. In the gut, GF mice expressed low levels of the MC tissue-homing markers CXCL1 and CXCL2 and harbored fewer MC which exhibited lower levels of MC protease-1 after challenge. Additionally, MC in GF mice were less mature as confirmed by flow-cytometry and reduced edema formation after injection of degranulation-provoking compound 48/80. Co-housing of GF mice with CV mice fully restored their susceptibility to develop FA. However, this did not occur when GF mice were mono-colonized with L. plantarum.ConclusionOur results demonstrate that microbiota-induced maturation and gut-homing of MC is a critical step for the development of symptoms of experimental FA. This new mechanistic insight into microbiota-MC-FA axis can be exploited in the prevention and treatment of FA in humans.

A pro-inflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
K Karimi ◽  
K Neumann ◽  
J Meiners ◽  
R Voetlause ◽  
W Dammermann ◽  
...  
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Immune Mediated

1886-P: Hepatic Type 2 Innate Lymphoid Cells Suppress Gluconeogenesis via the IL-33/GATA3/IL-13 Axis

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1886-P
Author(s):  
MASANORI FUJIMOTO ◽  
KOUTARO YOKOTE ◽  
TOMOAKI TANAKA
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells
Sign in / Sign up

Export Citation Format

Share Document